Urinary 8-Hydroxydeoxyguanosine Excretion as a Non-Invasive Marker of Neutrophil Activation in Animal Models of Inflammatory Bowel Disease

Background: Because free radicals contribute to ulcerative colitis and Crohn's disease, assessing oxidative load in vivo could provide a surrogate marker of inflammation and disease status. Methods: Electrochemical high-performance liquid chromatography was used to study urinary excretion of 8-...

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Veröffentlicht in:	Scandinavian journal of gastroenterology 1998, Vol.33 (6), p.628-636
Hauptverfasser:	DYKENS, J. A, BAGINSKI, T. J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Chromatography, High Pressure Liquid Deoxyguanosine - analogs & derivatives Deoxyguanosine - urine Dextran Sulfate Enema Gastroenterology. Liver. Pancreas. Abdomen Hydroxyl Radical - metabolism Inflammatory Bowel Diseases - chemically induced Inflammatory Bowel Diseases - immunology Inflammatory Bowel Diseases - urine Intestines - enzymology Male Medical sciences Neutrophil Activation Other diseases. Semiology Peroxidase - metabolism Rats Rats, Wistar Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Trinitrobenzenesulfonic Acid
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