Up-regulation of human alpha7 nicotinic receptors by chronic treatment with activator and antagonist ligands

This study examined the binding and functional properties of human alpha7 neuronal nicotinic acetylcholine receptors stably expressed in human embryonic kidney (HEK) 293 cells following chronic treatment with nicotinic receptor ligands. Treatment of cells with (-)-nicotine (100 microM) for 120 h inc...

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Veröffentlicht in:	European journal of pharmacology 1998-04, Vol.347 (1), p.131
Hauptverfasser:	Molinari, E J, Delbono, O, Messi, M L, Renganathan, M, Arneric, S P, Sullivan, J P, Gopalakrishnan, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Aconitine - analogs & derivatives Aconitine - pharmacology alpha7 Nicotinic Acetylcholine Receptor Benzylidene Compounds - pharmacology Binding Sites Bridged Bicyclo Compounds, Heterocyclic - pharmacology Bungarotoxins - metabolism Bungarotoxins - pharmacology Dimethylphenylpiperazinium Iodide - pharmacology Humans Insecticides - pharmacology Iodine Radioisotopes Kidney - drug effects Kidney - ultrastructure Kinetics Ligands Nicotine - pharmacology Nicotinic Agonists - pharmacology Nicotinic Antagonists - metabolism Nicotinic Antagonists - pharmacology Pyridines - pharmacology Receptors, Nicotinic - drug effects Receptors, Nicotinic - metabolism Receptors, Nicotinic - physiology Transfection Up-Regulation - drug effects
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