Relative abundance of organochlorine pesticides and polychlorinated biphenyls in adipose tissue and serum of women in Long Island, New York
Some organochlorine pesticides (OCPs) and PCBs are under investigation as possible risk factors for breast cancer because of their estrogenic properties and widespread presence in the environment. It is important to know whether adipose tissue used by some investigators and serum assays used by othe...
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| Veröffentlicht in: | Cancer epidemiology, biomarkers & prevention biomarkers & prevention, 1998-06, Vol.7 (6), p.489 |
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| creator | Stellman, S D Djordjevic, M V Muscat, J E Gong, L Bernstein, D Citron, M L White, A Kemeny, M Busch, E Nafziger, A N |
| description | Some organochlorine pesticides (OCPs) and PCBs are under investigation as possible risk factors for breast cancer because
of their estrogenic properties and widespread presence in the environment. It is important to know whether adipose tissue
used by some investigators and serum assays used by others can provide comparable information on body burden. Concentrations
of seven OCPs or their breakdown products as well as 14 PCB congeners were measured in the adipose tissue and serum of 293
women enrolled as controls in a case-control study of environmental factors for breast cancer in Long Island, New York, a
high-risk region. Adipose OCP/PCB levels were measured using a supercritical fluid extraction method developed by the authors.
1,1-Dichloro-2,2-di(4-chlorophenyl)ethylene (p,p'-DDE) was detected in all adipose and serum samples; two chlordane derivatives,
beta-hexachlorocyclohexane (a lindane isomer) and hexachlorobenzene, were detected in at least 92% of adipose samples. The
di-ortho hexachlorinated PCB congeners 2,4,5,2',4',5'-hexachlorobiphenyl and 2,3,4,2',4',5'-hexachlorobiphenyl were detected
in all adipose and over 98% of serum samples. 1,1-Dichloro-2,2-di(4-chlorophenyl)ethylene comprised 77% of total pesticide
residues in adipose and 71% in serum. 2,4,5,2',4',5'-Hexachlorobiphenyl comprised 24% of adipose and 21% of serum PCBs. The
relative concentration patterns of the 14 PCB congeners were similar to those reported in other human studies and were also
typical of patterns reported in environmental samples from various biota, including mammals and birds, but differed substantially
from patterns reported in occupationally exposed workers. All adipose-serum correlations for pesticides and most PCBs were
statistically significant. Either serum or adipose OCP/PCB levels of a variety of environmental organochlorine compounds may
serve as useful biomarkers of body burden. |
| format | Article |
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of their estrogenic properties and widespread presence in the environment. It is important to know whether adipose tissue
used by some investigators and serum assays used by others can provide comparable information on body burden. Concentrations
of seven OCPs or their breakdown products as well as 14 PCB congeners were measured in the adipose tissue and serum of 293
women enrolled as controls in a case-control study of environmental factors for breast cancer in Long Island, New York, a
high-risk region. Adipose OCP/PCB levels were measured using a supercritical fluid extraction method developed by the authors.
1,1-Dichloro-2,2-di(4-chlorophenyl)ethylene (p,p'-DDE) was detected in all adipose and serum samples; two chlordane derivatives,
beta-hexachlorocyclohexane (a lindane isomer) and hexachlorobenzene, were detected in at least 92% of adipose samples. The
di-ortho hexachlorinated PCB congeners 2,4,5,2',4',5'-hexachlorobiphenyl and 2,3,4,2',4',5'-hexachlorobiphenyl were detected
in all adipose and over 98% of serum samples. 1,1-Dichloro-2,2-di(4-chlorophenyl)ethylene comprised 77% of total pesticide
residues in adipose and 71% in serum. 2,4,5,2',4',5'-Hexachlorobiphenyl comprised 24% of adipose and 21% of serum PCBs. The
relative concentration patterns of the 14 PCB congeners were similar to those reported in other human studies and were also
typical of patterns reported in environmental samples from various biota, including mammals and birds, but differed substantially
from patterns reported in occupationally exposed workers. All adipose-serum correlations for pesticides and most PCBs were
statistically significant. Either serum or adipose OCP/PCB levels of a variety of environmental organochlorine compounds may
serve as useful biomarkers of body burden.</description><identifier>ISSN: 1055-9965</identifier><identifier>EISSN: 1538-7755</identifier><identifier>PMID: 9641493</identifier><language>eng</language><publisher>United States: American Association for Cancer Research</publisher><subject>Adipose Tissue - metabolism ; Adult ; Aged ; Aged, 80 and over ; Biomarkers, Tumor - blood ; Biomarkers, Tumor - metabolism ; Breast Neoplasms - etiology ; Case-Control Studies ; Dichlorodiphenyl Dichloroethylene - blood ; Dichlorodiphenyl Dichloroethylene - metabolism ; Environmental Pollution - adverse effects ; Female ; Humans ; Insecticides - blood ; Insecticides - metabolism ; Middle Aged ; New York ; Polychlorinated Biphenyls - blood ; Polychlorinated Biphenyls - metabolism ; Risk Factors</subject><ispartof>Cancer epidemiology, biomarkers & prevention, 1998-06, Vol.7 (6), p.489</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9641493$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Stellman, S D</creatorcontrib><creatorcontrib>Djordjevic, M V</creatorcontrib><creatorcontrib>Muscat, J E</creatorcontrib><creatorcontrib>Gong, L</creatorcontrib><creatorcontrib>Bernstein, D</creatorcontrib><creatorcontrib>Citron, M L</creatorcontrib><creatorcontrib>White, A</creatorcontrib><creatorcontrib>Kemeny, M</creatorcontrib><creatorcontrib>Busch, E</creatorcontrib><creatorcontrib>Nafziger, A N</creatorcontrib><title>Relative abundance of organochlorine pesticides and polychlorinated biphenyls in adipose tissue and serum of women in Long Island, New York</title><title>Cancer epidemiology, biomarkers & prevention</title><addtitle>Cancer Epidemiol Biomarkers Prev</addtitle><description>Some organochlorine pesticides (OCPs) and PCBs are under investigation as possible risk factors for breast cancer because
of their estrogenic properties and widespread presence in the environment. It is important to know whether adipose tissue
used by some investigators and serum assays used by others can provide comparable information on body burden. Concentrations
of seven OCPs or their breakdown products as well as 14 PCB congeners were measured in the adipose tissue and serum of 293
women enrolled as controls in a case-control study of environmental factors for breast cancer in Long Island, New York, a
high-risk region. Adipose OCP/PCB levels were measured using a supercritical fluid extraction method developed by the authors.
1,1-Dichloro-2,2-di(4-chlorophenyl)ethylene (p,p'-DDE) was detected in all adipose and serum samples; two chlordane derivatives,
beta-hexachlorocyclohexane (a lindane isomer) and hexachlorobenzene, were detected in at least 92% of adipose samples. The
di-ortho hexachlorinated PCB congeners 2,4,5,2',4',5'-hexachlorobiphenyl and 2,3,4,2',4',5'-hexachlorobiphenyl were detected
in all adipose and over 98% of serum samples. 1,1-Dichloro-2,2-di(4-chlorophenyl)ethylene comprised 77% of total pesticide
residues in adipose and 71% in serum. 2,4,5,2',4',5'-Hexachlorobiphenyl comprised 24% of adipose and 21% of serum PCBs. The
relative concentration patterns of the 14 PCB congeners were similar to those reported in other human studies and were also
typical of patterns reported in environmental samples from various biota, including mammals and birds, but differed substantially
from patterns reported in occupationally exposed workers. All adipose-serum correlations for pesticides and most PCBs were
statistically significant. Either serum or adipose OCP/PCB levels of a variety of environmental organochlorine compounds may
serve as useful biomarkers of body burden.</description><subject>Adipose Tissue - metabolism</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biomarkers, Tumor - blood</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Breast Neoplasms - etiology</subject><subject>Case-Control Studies</subject><subject>Dichlorodiphenyl Dichloroethylene - blood</subject><subject>Dichlorodiphenyl Dichloroethylene - metabolism</subject><subject>Environmental Pollution - adverse effects</subject><subject>Female</subject><subject>Humans</subject><subject>Insecticides - blood</subject><subject>Insecticides - metabolism</subject><subject>Middle Aged</subject><subject>New York</subject><subject>Polychlorinated Biphenyls - blood</subject><subject>Polychlorinated Biphenyls - metabolism</subject><subject>Risk Factors</subject><issn>1055-9965</issn><issn>1538-7755</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNotkF1LwzAYhYMoc05_gpArryykH2_TXMpQNxgKohdelTR5u0bbpCStY7_BP23ndnUOPA_n4pyReQxpEXEOcD51BhAJkcMluQrhizHGBcCMzESexZlI5-T3DVs5mB-kshqtllYhdTV1fiutU03rvLFIewyDUUZjoNJq2rt2f2JyQE0r0zdo922gxlKpTe8C0sGEMOK_H9CP3WF25zq0B2nj7JauQzvRe_qCO_rp_Pc1uahlG_DmlAvy8fT4vlxFm9fn9fJhEzVJyoeo1kwhFMiTLGcSVCYUsLpQkmVxUWOsUiGqWAiQHCdBxnnKEwaooC5EAnG6ILfH3X6sOtRl700n_b48nTLxuyNvzLbZGY-lOvziPQaUXjUlL_MyK0T6B3J6bxo</recordid><startdate>19980601</startdate><enddate>19980601</enddate><creator>Stellman, S D</creator><creator>Djordjevic, M V</creator><creator>Muscat, J E</creator><creator>Gong, L</creator><creator>Bernstein, D</creator><creator>Citron, M L</creator><creator>White, A</creator><creator>Kemeny, M</creator><creator>Busch, E</creator><creator>Nafziger, A N</creator><general>American Association for Cancer Research</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>19980601</creationdate><title>Relative abundance of organochlorine pesticides and polychlorinated biphenyls in adipose tissue and serum of women in Long Island, New York</title><author>Stellman, S D ; Djordjevic, M V ; Muscat, J E ; Gong, L ; Bernstein, D ; Citron, M L ; White, A ; Kemeny, M ; Busch, E ; Nafziger, A N</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h237t-fd0ce58e72460a5c49c50f8ca0418fe1c399b1995a7e60aa1637205ec5f892513</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Adipose Tissue - metabolism</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biomarkers, Tumor - blood</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Breast Neoplasms - etiology</topic><topic>Case-Control Studies</topic><topic>Dichlorodiphenyl Dichloroethylene - blood</topic><topic>Dichlorodiphenyl Dichloroethylene - metabolism</topic><topic>Environmental Pollution - adverse effects</topic><topic>Female</topic><topic>Humans</topic><topic>Insecticides - blood</topic><topic>Insecticides - metabolism</topic><topic>Middle Aged</topic><topic>New York</topic><topic>Polychlorinated Biphenyls - blood</topic><topic>Polychlorinated Biphenyls - metabolism</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Stellman, S D</creatorcontrib><creatorcontrib>Djordjevic, M V</creatorcontrib><creatorcontrib>Muscat, J E</creatorcontrib><creatorcontrib>Gong, L</creatorcontrib><creatorcontrib>Bernstein, D</creatorcontrib><creatorcontrib>Citron, M L</creatorcontrib><creatorcontrib>White, A</creatorcontrib><creatorcontrib>Kemeny, M</creatorcontrib><creatorcontrib>Busch, E</creatorcontrib><creatorcontrib>Nafziger, A N</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Cancer epidemiology, biomarkers & prevention</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Stellman, S D</au><au>Djordjevic, M V</au><au>Muscat, J E</au><au>Gong, L</au><au>Bernstein, D</au><au>Citron, M L</au><au>White, A</au><au>Kemeny, M</au><au>Busch, E</au><au>Nafziger, A N</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relative abundance of organochlorine pesticides and polychlorinated biphenyls in adipose tissue and serum of women in Long Island, New York</atitle><jtitle>Cancer epidemiology, biomarkers & prevention</jtitle><addtitle>Cancer Epidemiol Biomarkers Prev</addtitle><date>1998-06-01</date><risdate>1998</risdate><volume>7</volume><issue>6</issue><spage>489</spage><pages>489-</pages><issn>1055-9965</issn><eissn>1538-7755</eissn><abstract>Some organochlorine pesticides (OCPs) and PCBs are under investigation as possible risk factors for breast cancer because
of their estrogenic properties and widespread presence in the environment. It is important to know whether adipose tissue
used by some investigators and serum assays used by others can provide comparable information on body burden. Concentrations
of seven OCPs or their breakdown products as well as 14 PCB congeners were measured in the adipose tissue and serum of 293
women enrolled as controls in a case-control study of environmental factors for breast cancer in Long Island, New York, a
high-risk region. Adipose OCP/PCB levels were measured using a supercritical fluid extraction method developed by the authors.
1,1-Dichloro-2,2-di(4-chlorophenyl)ethylene (p,p'-DDE) was detected in all adipose and serum samples; two chlordane derivatives,
beta-hexachlorocyclohexane (a lindane isomer) and hexachlorobenzene, were detected in at least 92% of adipose samples. The
di-ortho hexachlorinated PCB congeners 2,4,5,2',4',5'-hexachlorobiphenyl and 2,3,4,2',4',5'-hexachlorobiphenyl were detected
in all adipose and over 98% of serum samples. 1,1-Dichloro-2,2-di(4-chlorophenyl)ethylene comprised 77% of total pesticide
residues in adipose and 71% in serum. 2,4,5,2',4',5'-Hexachlorobiphenyl comprised 24% of adipose and 21% of serum PCBs. The
relative concentration patterns of the 14 PCB congeners were similar to those reported in other human studies and were also
typical of patterns reported in environmental samples from various biota, including mammals and birds, but differed substantially
from patterns reported in occupationally exposed workers. All adipose-serum correlations for pesticides and most PCBs were
statistically significant. Either serum or adipose OCP/PCB levels of a variety of environmental organochlorine compounds may
serve as useful biomarkers of body burden.</abstract><cop>United States</cop><pub>American Association for Cancer Research</pub><pmid>9641493</pmid></addata></record> |
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| identifier | ISSN: 1055-9965 |
| ispartof | Cancer epidemiology, biomarkers & prevention, 1998-06, Vol.7 (6), p.489 |
| issn | 1055-9965 1538-7755 |
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| recordid | cdi_pubmed_primary_9641493 |
| source | MEDLINE; American Association for Cancer Research; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adipose Tissue - metabolism Adult Aged Aged, 80 and over Biomarkers, Tumor - blood Biomarkers, Tumor - metabolism Breast Neoplasms - etiology Case-Control Studies Dichlorodiphenyl Dichloroethylene - blood Dichlorodiphenyl Dichloroethylene - metabolism Environmental Pollution - adverse effects Female Humans Insecticides - blood Insecticides - metabolism Middle Aged New York Polychlorinated Biphenyls - blood Polychlorinated Biphenyls - metabolism Risk Factors |
| title | Relative abundance of organochlorine pesticides and polychlorinated biphenyls in adipose tissue and serum of women in Long Island, New York |
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