Interconversion of the Ligand Arrays in the CD and EF Sites of Oncomodulin. Influence on Ca2+-Binding Affinity

The parvalbumin metal ion-binding sites differ at the +z and − x residues:  Whereas the CD site employs serine and glutamate (or aspartate), respectively, the EF site employs aspartate and glycine. Although frequently indistinguishable in Ca2+- and Mg2+-binding assays, the CD and EF sites nonetheles...

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