Experimental studies on cataract
I have discussed five aspects of lens metabolism and their possible relationship to cataract in man, and this has left me with five fundamental questions to be answered. 1. Are the fluorescent tryptophan derivatives, found only in the lens of man and higher primates, involved in the development of b...
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| Veröffentlicht in: | Investigative ophthalmology & visual science 1976-09, Vol.15 (9), p.685 |
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| creator | van Heyningen, R |
| description | I have discussed five aspects of lens metabolism and their possible relationship to cataract in man, and this has left me with five fundamental questions to be answered. 1. Are the fluorescent tryptophan derivatives, found only in the lens of man and higher primates, involved in the development of brown nuclear cataract? 2. Is naphthalene cataract in rabbits a model for any type of cataract in man--i.e., are quinones ever formed in the human eye? 3. Is diabetes the only cataract in which osmotic swelling is important? 4. Does self-digestion of protein in the human lens contribute to cataract development? 5. Are the consequences of the abnormal maturation of lens fibers, which occurs in tryptophan deficiency cataract in rats, ever seen in man? |
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Are the fluorescent tryptophan derivatives, found only in the lens of man and higher primates, involved in the development of brown nuclear cataract? 2. Is naphthalene cataract in rabbits a model for any type of cataract in man--i.e., are quinones ever formed in the human eye? 3. Is diabetes the only cataract in which osmotic swelling is important? 4. Does self-digestion of protein in the human lens contribute to cataract development? 5. Are the consequences of the abnormal maturation of lens fibers, which occurs in tryptophan deficiency cataract in rats, ever seen in man?</description><identifier>ISSN: 0146-0404</identifier><identifier>EISSN: 1552-5783</identifier><identifier>PMID: 961716</identifier><language>eng</language><publisher>United States: ARVO</publisher><subject>Aging ; Animals ; Ascorbic Acid - metabolism ; Cataract - chemically induced ; Cataract - metabolism ; Crystallins - metabolism ; Diabetic Retinopathy - metabolism ; Humans ; Lens, Crystalline - enzymology ; Lens, Crystalline - metabolism ; Naphthalenes - adverse effects ; Naphthalenes - metabolism ; Naphthoquinones - metabolism ; Peptide Hydrolases - metabolism ; Sorbitol - metabolism ; Tryptophan - deficiency ; Tryptophan - metabolism</subject><ispartof>Investigative ophthalmology & visual science, 1976-09, Vol.15 (9), p.685</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/961716$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>van Heyningen, R</creatorcontrib><title>Experimental studies on cataract</title><title>Investigative ophthalmology & visual science</title><addtitle>Invest Ophthalmol Vis Sci</addtitle><description>I have discussed five aspects of lens metabolism and their possible relationship to cataract in man, and this has left me with five fundamental questions to be answered. 1. Are the fluorescent tryptophan derivatives, found only in the lens of man and higher primates, involved in the development of brown nuclear cataract? 2. Is naphthalene cataract in rabbits a model for any type of cataract in man--i.e., are quinones ever formed in the human eye? 3. Is diabetes the only cataract in which osmotic swelling is important? 4. Does self-digestion of protein in the human lens contribute to cataract development? 5. Are the consequences of the abnormal maturation of lens fibers, which occurs in tryptophan deficiency cataract in rats, ever seen in man?</description><subject>Aging</subject><subject>Animals</subject><subject>Ascorbic Acid - metabolism</subject><subject>Cataract - chemically induced</subject><subject>Cataract - metabolism</subject><subject>Crystallins - metabolism</subject><subject>Diabetic Retinopathy - metabolism</subject><subject>Humans</subject><subject>Lens, Crystalline - enzymology</subject><subject>Lens, Crystalline - metabolism</subject><subject>Naphthalenes - adverse effects</subject><subject>Naphthalenes - metabolism</subject><subject>Naphthoquinones - metabolism</subject><subject>Peptide Hydrolases - metabolism</subject><subject>Sorbitol - metabolism</subject><subject>Tryptophan - deficiency</subject><subject>Tryptophan - metabolism</subject><issn>0146-0404</issn><issn>1552-5783</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1976</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNotjstKxEAURBvxlRn9AxfZuGy4nX5mKcP4gAE3zrq56b4xkWQM6QzRvzcQV7U4RdW5YJnQuuDaOnnJMhDKcFCgbtkmpS-AQogCbth1aYQVJmP5_megse3pNGGXp-kcW0r59ykPOOGIYbpjVzV2ie7_c8uOz_uP3Ss_vL-87Z4OvCmknniwUVZWxFBaDEDRSlXISBU4clTqennW0gSSRtnaISBEZ0mUQBJB10pu2cO6O5yrnqIfFikcf_0quuDHFTftZzO3I_nUY9ctZeHneRbal944Lf8A1jRGlw</recordid><startdate>197609</startdate><enddate>197609</enddate><creator>van Heyningen, R</creator><general>ARVO</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>197609</creationdate><title>Experimental studies on cataract</title><author>van Heyningen, R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h235t-c7d3b71dc97ac0ed73423deb08e8e95f002536ce3647f8a0a0d87e190e3a05f43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1976</creationdate><topic>Aging</topic><topic>Animals</topic><topic>Ascorbic Acid - metabolism</topic><topic>Cataract - chemically induced</topic><topic>Cataract - metabolism</topic><topic>Crystallins - metabolism</topic><topic>Diabetic Retinopathy - metabolism</topic><topic>Humans</topic><topic>Lens, Crystalline - enzymology</topic><topic>Lens, Crystalline - metabolism</topic><topic>Naphthalenes - adverse effects</topic><topic>Naphthalenes - metabolism</topic><topic>Naphthoquinones - metabolism</topic><topic>Peptide Hydrolases - metabolism</topic><topic>Sorbitol - metabolism</topic><topic>Tryptophan - deficiency</topic><topic>Tryptophan - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>van Heyningen, R</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Investigative ophthalmology & visual science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>van Heyningen, R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Experimental studies on cataract</atitle><jtitle>Investigative ophthalmology & visual science</jtitle><addtitle>Invest Ophthalmol Vis Sci</addtitle><date>1976-09</date><risdate>1976</risdate><volume>15</volume><issue>9</issue><spage>685</spage><pages>685-</pages><issn>0146-0404</issn><eissn>1552-5783</eissn><abstract>I have discussed five aspects of lens metabolism and their possible relationship to cataract in man, and this has left me with five fundamental questions to be answered. 1. 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| fulltext | fulltext |
| identifier | ISSN: 0146-0404 |
| ispartof | Investigative ophthalmology & visual science, 1976-09, Vol.15 (9), p.685 |
| issn | 0146-0404 1552-5783 |
| language | eng |
| recordid | cdi_pubmed_primary_961716 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Aging Animals Ascorbic Acid - metabolism Cataract - chemically induced Cataract - metabolism Crystallins - metabolism Diabetic Retinopathy - metabolism Humans Lens, Crystalline - enzymology Lens, Crystalline - metabolism Naphthalenes - adverse effects Naphthalenes - metabolism Naphthoquinones - metabolism Peptide Hydrolases - metabolism Sorbitol - metabolism Tryptophan - deficiency Tryptophan - metabolism |
| title | Experimental studies on cataract |
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