Identification of an Additional Negative Regulatory Region for p53 Sequence-Specific DNA Binding

The DNA binding activity of p53 is crucial for its tumor suppressor function and is subject to tight regulation. Previous studies revealed that the inhibitory function of the p53 C terminus is implicated in the latent, low affinity sequence-specific DNA binding activity of p53 in the uninduced state...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1998-05, Vol.95 (11), p.6079-6084
Hauptverfasser:	Muller-Tiemann, Beate F., Halazonetis, Thanos D., Elting, James J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Antibodies Binding Sites - genetics Biochemistry Biological Sciences Chemical precipitation Deoxyribonucleic acid DNA DNA, Bacterial - genetics DNA, Bacterial - metabolism Drug regulation Escherichia coli Genes Genes, p53 Government regulation Molecular interactions Molecules Protein Binding - genetics Proteins Sequence Analysis Transactivation Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Tumors
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