The molecular mechanisms of 5-fluoro-2'-deoxyuridine induced cell death

The molecular mechanism of cell death induced by 5-Fluoro-2'-deoxyuridine (FUdR) was investigated. FUdR caused cell death to induce dNTP pool imbalance and following DNA double strand breaks in mouse mammary tumor FM3A cells. We isolated a new endonuclease from FUdR-treated cells, named endonuc...

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Veröffentlicht in:	Nucleic acids symposium series (1979) 1997 (37), p.135
Hauptverfasser:	Nagano, A, Kakutani, T, Matumoto, Y, Ebara, Y, Kanja, K, Kankawa, S, Wataya, Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Cell Death - drug effects Cell Line Deoxyribonucleases, Type I Site-Specific Deoxyribonucleotides - metabolism DNA Fragmentation Endodeoxyribonucleases - metabolism Endopeptidases - metabolism Female Floxuridine - toxicity Mammary Neoplasms, Experimental Mice Protease Inhibitors - pharmacology
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