Impairment of the actin-myosin interaction in permeabilized cardiac trabeculae after chronic doxorubicin treatment

The development of chronic cardiotoxicity in cancer patients treated with doxorubicin (DOX) and other anthracycline antineoplastic agents is a major dose-limiting factor. In a previous study, we demonstrated an acute effect of anthracyclines on the actin-myosin contractile system. Here, we report ch...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Clinical cancer research 1998-04, Vol.4 (4), p.1031-1037
Hauptverfasser:	BOTTONE, A. E, VOEST, E. E, DE BEER, E. L
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - metabolism Animals Antibiotics, Antineoplastic - pharmacology Biological and medical sciences Caffeine - adverse effects Calcium - pharmacology Doxorubicin - pharmacology Drug toxicity and drugs side effects treatment Female Heart - drug effects Heart - physiology Male Medical sciences Muscle Contraction - drug effects Myocardial Contraction - drug effects Myosins - metabolism Pharmacology. Drug treatments Rats Sarcoplasmic Reticulum - drug effects Sarcoplasmic Reticulum - physiology Toxicity: cardiovascular system
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!