ZAP-70-dependent and -independent activation of Erk in Jurkat T cells. Differences in signaling induced by H2o2 and Cd3 cross-linking

Oxidative stress in T cells induces signaling events similar to those initiated by T cell antigen receptor engagement, including tyrosine phosphorylation and activation of the critical protein-tyrosine kinase ZAP-70. Distal signaling events such as the activation of mitogen-activated protein kinases...

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Veröffentlicht in:	The Journal of biological chemistry 1998-04, Vol.273 (17), p.10771
Hauptverfasser:	Griffith, C E, Zhang, W, Wange, R L
Format:	Artikel
Sprache:	eng
Schlagworte:	Calcium-Calmodulin-Dependent Protein Kinases - metabolism CD3 Complex - metabolism Enzyme Activation Humans Hydrogen Peroxide - pharmacology Jurkat Cells Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 Mitogen-Activated Protein Kinases Oxidative Stress Phosphorylation Protein-Tyrosine Kinases - metabolism Receptors, Antigen, T-Cell - metabolism Signal Transduction - drug effects ZAP-70 Protein-Tyrosine Kinase
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