Stereoselective actions of halothane at GABA A receptors

Isoflurane anesthesia exhibits stereoselectivity, and a corresponding stereoselectivity ((+)->(−)-isomer) has been reported at GABA A receptors in vitro. The objective of the present study was to determine if the positive modulatory actions of halothane at GABA A receptors exhibited a similar ste...

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Veröffentlicht in:	European journal of pharmacology 1998-01, Vol.341 (2), p.349-352
Hauptverfasser:	Harris, Bradford D, J. Moody, Eric, Skolnick, Phil
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthetic, inhalational Anesthetics, Inhalation - chemistry Anesthetics, Inhalation - pharmacology Animals Binding, Competitive Drug Interactions Flunitrazepam Flunitrazepam - pharmacology GABA ( γ-aminobutyric acid) GABA A receptor complex GABA Agonists - pharmacology GABA Modulators - pharmacology Halothane Halothane - chemistry Halothane - pharmacology Male Mice Muscimol - pharmacology Receptors, GABA-A - drug effects Receptors, GABA-A - metabolism Stereoisomerism Stereoselectivity
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