Phase I study of the orally administered butyrate prodrug, tributyrin, in patients with solid tumors

Butyrates have been studied as cancer differentiation agents in vitro and as a treatment for hemoglobinopathies. Tributyrin, a triglyceride with butyrate molecules esterified at the 1, 2, and 3 positions, induces differentiation and/or growth inhibition of a number of cell lines in vitro. When given...

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Veröffentlicht in:	Clinical cancer research 1998-03, Vol.4 (3), p.629-634
Hauptverfasser:	CONLEY, B. A, EGORIN, M. J, TAIT, N, ROSEN, D. M, SAUSVILLE, E. A, DOVER, G, FRAM, R. J, VAN ECHO, D. A
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Adult Aged Antineoplastic agents Antineoplastic Agents - adverse effects Antineoplastic Agents - blood Antineoplastic Agents - pharmacokinetics Biological and medical sciences Chemotherapy Dose-Response Relationship, Drug Drug Administration Schedule Female Humans Male Medical sciences Middle Aged Neoplasms - blood Neoplasms - drug therapy Pharmacology. Drug treatments Prodrugs - administration & dosage Prodrugs - adverse effects Prodrugs - pharmacokinetics Triglycerides - adverse effects Triglycerides - blood Triglycerides - pharmacokinetics
Online-Zugang:	Volltext
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