Translocations involving chromosome 12p11-13, methotrexate metabolism, and outcome in childhood B-progenitor cell acute lymphoblastic leukemia: a Pediatric Oncology Group study

Children with B-progenitor cell acute lymphoblastic leukemia whose lymphoblasts at diagnosis accumulate high levels of methotrexate (MTX) and MTX polyglutamates (MTXPGs) appear to have a good prognosis. This has been attributed to increased sensitivity of their blast cells to MTX. However, the propo...

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Veröffentlicht in:	Clinical cancer research 1998-01, Vol.4 (1), p.183-188
Hauptverfasser:	WHITEHEAD, V. M, VUCHICH, M.-J, KAMEN, B. A, WATSON, M. S, LOOK, A. T, PULLEN, D. J, CAMITTA, B, COOLEY, L, LAUER, S. J, MAHONEY, D. H, SHUSTER, J. J, PAYMENT, C, BERNSTEIN, M. L, AKABUTU, J. J, BOWEN, T
Format:	Artikel
Sprache:	eng
Schlagworte:	Antimetabolites, Antineoplastic - metabolism Antineoplastic agents Biological and medical sciences Chemotherapy Child Child, Preschool Chromosomes, Human, Pair 12 DNA-Binding Proteins - genetics ETS Translocation Variant 6 Protein Female Humans Infant Male Medical sciences Methotrexate - metabolism Pharmacology. Drug treatments Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - genetics Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics Precursor Cell Lymphoblastic Leukemia-Lymphoma - metabolism Proto-Oncogene Proteins c-ets Repressor Proteins Transcription Factors - genetics Translocation, Genetic
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