Translocations involving chromosome 12p11-13, methotrexate metabolism, and outcome in childhood B-progenitor cell acute lymphoblastic leukemia: a Pediatric Oncology Group study
Children with B-progenitor cell acute lymphoblastic leukemia whose lymphoblasts at diagnosis accumulate high levels of methotrexate (MTX) and MTX polyglutamates (MTXPGs) appear to have a good prognosis. This has been attributed to increased sensitivity of their blast cells to MTX. However, the propo...
Gespeichert in:
| Veröffentlicht in: | Clinical cancer research 1998-01, Vol.4 (1), p.183-188 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 188 |
|---|---|
| container_issue | 1 |
| container_start_page | 183 |
| container_title | Clinical cancer research |
| container_volume | 4 |
| creator | WHITEHEAD, V. M VUCHICH, M.-J KAMEN, B. A WATSON, M. S LOOK, A. T PULLEN, D. J CAMITTA, B COOLEY, L LAUER, S. J MAHONEY, D. H SHUSTER, J. J PAYMENT, C BERNSTEIN, M. L AKABUTU, J. J BOWEN, T |
| description | Children with B-progenitor cell acute lymphoblastic leukemia whose lymphoblasts at diagnosis accumulate high levels of methotrexate
(MTX) and MTX polyglutamates (MTXPGs) appear to have a good prognosis. This has been attributed to increased sensitivity of
their blast cells to MTX. However, the proportion of children who are cured of B-progenitor cell acute lymphoblastic leukemia
exceeds the number whose lymphoblasts accumulate high MTXPG levels. We report that lymphoblasts from patients with < 50 chromosomes
who have translocations that involve the short arm of chromosome 12 accumulate low levels of MTXPGs. These patients appear
to have an excellent survival because none of 14 patients with translocations affecting 12p has relapsed, 26-79 months following
diagnosis. |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed_pasca</sourceid><recordid>TN_cdi_pubmed_primary_9516969</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>9516969</sourcerecordid><originalsourceid>FETCH-LOGICAL-h266t-e5430e806a641c6f8f16a43e0f9b7c62a0f0294f619eea1dde9f821a892ac08b3</originalsourceid><addsrcrecordid>eNo9kM1O3TAQhSPUCijlEZC8QF0RyeMkvnF3BQGthEQXdB1NnMmNwclEtgO9b8UjEsQVq_k53zmLc5AdQ1Vt8kLp6su6y02dy7JQR9m3GB-lhBJkeZgdmgq00eY4e30IOEXPFpPjKQo3PbN_dtNW2CHwyJFHEqBmgByKCzFSGjgF-o-J3g9s2bs4XgicOsFLsu-4m1az893A3InLfA68pcklDsKS9wLtspr9bpwHbj3G5KzwtDzR6PCnQPGXOocprN_7ybLn7U7cBl5mEdPS7b5nX3v0kU738yT7d3P9cPU7v7u__XP16y4flNYpp6osJNVSoy7B6r7uQWNZkOxNu7FaoeylMmWvwRAhdB2ZvlaAtVFoZd0WJ9nZR-68tCN1zRzciGHX7Jtb9fO9jtGi79carYufmAKopZEr9uMDG9x2eHGBGruCFAJFwmCHpmyggboo3gA4OYmc</addsrcrecordid><sourcetype>Index Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Translocations involving chromosome 12p11-13, methotrexate metabolism, and outcome in childhood B-progenitor cell acute lymphoblastic leukemia: a Pediatric Oncology Group study</title><source>MEDLINE</source><source>American Association for Cancer Research</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>WHITEHEAD, V. M ; VUCHICH, M.-J ; KAMEN, B. A ; WATSON, M. S ; LOOK, A. T ; PULLEN, D. J ; CAMITTA, B ; COOLEY, L ; LAUER, S. J ; MAHONEY, D. H ; SHUSTER, J. J ; PAYMENT, C ; BERNSTEIN, M. L ; AKABUTU, J. J ; BOWEN, T</creator><creatorcontrib>WHITEHEAD, V. M ; VUCHICH, M.-J ; KAMEN, B. A ; WATSON, M. S ; LOOK, A. T ; PULLEN, D. J ; CAMITTA, B ; COOLEY, L ; LAUER, S. J ; MAHONEY, D. H ; SHUSTER, J. J ; PAYMENT, C ; BERNSTEIN, M. L ; AKABUTU, J. J ; BOWEN, T</creatorcontrib><description>Children with B-progenitor cell acute lymphoblastic leukemia whose lymphoblasts at diagnosis accumulate high levels of methotrexate
(MTX) and MTX polyglutamates (MTXPGs) appear to have a good prognosis. This has been attributed to increased sensitivity of
their blast cells to MTX. However, the proportion of children who are cured of B-progenitor cell acute lymphoblastic leukemia
exceeds the number whose lymphoblasts accumulate high MTXPG levels. We report that lymphoblasts from patients with < 50 chromosomes
who have translocations that involve the short arm of chromosome 12 accumulate low levels of MTXPGs. These patients appear
to have an excellent survival because none of 14 patients with translocations affecting 12p has relapsed, 26-79 months following
diagnosis.</description><identifier>ISSN: 1078-0432</identifier><identifier>EISSN: 1557-3265</identifier><identifier>PMID: 9516969</identifier><language>eng</language><publisher>Philadelphia, PA: American Association for Cancer Research</publisher><subject>Antimetabolites, Antineoplastic - metabolism ; Antineoplastic agents ; Biological and medical sciences ; Chemotherapy ; Child ; Child, Preschool ; Chromosomes, Human, Pair 12 ; DNA-Binding Proteins - genetics ; ETS Translocation Variant 6 Protein ; Female ; Humans ; Infant ; Male ; Medical sciences ; Methotrexate - metabolism ; Pharmacology. Drug treatments ; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - genetics ; Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics ; Precursor Cell Lymphoblastic Leukemia-Lymphoma - metabolism ; Proto-Oncogene Proteins c-ets ; Repressor Proteins ; Transcription Factors - genetics ; Translocation, Genetic</subject><ispartof>Clinical cancer research, 1998-01, Vol.4 (1), p.183-188</ispartof><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4010</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2118090$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9516969$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>WHITEHEAD, V. M</creatorcontrib><creatorcontrib>VUCHICH, M.-J</creatorcontrib><creatorcontrib>KAMEN, B. A</creatorcontrib><creatorcontrib>WATSON, M. S</creatorcontrib><creatorcontrib>LOOK, A. T</creatorcontrib><creatorcontrib>PULLEN, D. J</creatorcontrib><creatorcontrib>CAMITTA, B</creatorcontrib><creatorcontrib>COOLEY, L</creatorcontrib><creatorcontrib>LAUER, S. J</creatorcontrib><creatorcontrib>MAHONEY, D. H</creatorcontrib><creatorcontrib>SHUSTER, J. J</creatorcontrib><creatorcontrib>PAYMENT, C</creatorcontrib><creatorcontrib>BERNSTEIN, M. L</creatorcontrib><creatorcontrib>AKABUTU, J. J</creatorcontrib><creatorcontrib>BOWEN, T</creatorcontrib><title>Translocations involving chromosome 12p11-13, methotrexate metabolism, and outcome in childhood B-progenitor cell acute lymphoblastic leukemia: a Pediatric Oncology Group study</title><title>Clinical cancer research</title><addtitle>Clin Cancer Res</addtitle><description>Children with B-progenitor cell acute lymphoblastic leukemia whose lymphoblasts at diagnosis accumulate high levels of methotrexate
(MTX) and MTX polyglutamates (MTXPGs) appear to have a good prognosis. This has been attributed to increased sensitivity of
their blast cells to MTX. However, the proportion of children who are cured of B-progenitor cell acute lymphoblastic leukemia
exceeds the number whose lymphoblasts accumulate high MTXPG levels. We report that lymphoblasts from patients with < 50 chromosomes
who have translocations that involve the short arm of chromosome 12 accumulate low levels of MTXPGs. These patients appear
to have an excellent survival because none of 14 patients with translocations affecting 12p has relapsed, 26-79 months following
diagnosis.</description><subject>Antimetabolites, Antineoplastic - metabolism</subject><subject>Antineoplastic agents</subject><subject>Biological and medical sciences</subject><subject>Chemotherapy</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Chromosomes, Human, Pair 12</subject><subject>DNA-Binding Proteins - genetics</subject><subject>ETS Translocation Variant 6 Protein</subject><subject>Female</subject><subject>Humans</subject><subject>Infant</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Methotrexate - metabolism</subject><subject>Pharmacology. Drug treatments</subject><subject>Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - genetics</subject><subject>Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics</subject><subject>Precursor Cell Lymphoblastic Leukemia-Lymphoma - metabolism</subject><subject>Proto-Oncogene Proteins c-ets</subject><subject>Repressor Proteins</subject><subject>Transcription Factors - genetics</subject><subject>Translocation, Genetic</subject><issn>1078-0432</issn><issn>1557-3265</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kM1O3TAQhSPUCijlEZC8QF0RyeMkvnF3BQGthEQXdB1NnMmNwclEtgO9b8UjEsQVq_k53zmLc5AdQ1Vt8kLp6su6y02dy7JQR9m3GB-lhBJkeZgdmgq00eY4e30IOEXPFpPjKQo3PbN_dtNW2CHwyJFHEqBmgByKCzFSGjgF-o-J3g9s2bs4XgicOsFLsu-4m1az893A3InLfA68pcklDsKS9wLtspr9bpwHbj3G5KzwtDzR6PCnQPGXOocprN_7ybLn7U7cBl5mEdPS7b5nX3v0kU738yT7d3P9cPU7v7u__XP16y4flNYpp6osJNVSoy7B6r7uQWNZkOxNu7FaoeylMmWvwRAhdB2ZvlaAtVFoZd0WJ9nZR-68tCN1zRzciGHX7Jtb9fO9jtGi79carYufmAKopZEr9uMDG9x2eHGBGruCFAJFwmCHpmyggboo3gA4OYmc</recordid><startdate>19980101</startdate><enddate>19980101</enddate><creator>WHITEHEAD, V. M</creator><creator>VUCHICH, M.-J</creator><creator>KAMEN, B. A</creator><creator>WATSON, M. S</creator><creator>LOOK, A. T</creator><creator>PULLEN, D. J</creator><creator>CAMITTA, B</creator><creator>COOLEY, L</creator><creator>LAUER, S. J</creator><creator>MAHONEY, D. H</creator><creator>SHUSTER, J. J</creator><creator>PAYMENT, C</creator><creator>BERNSTEIN, M. L</creator><creator>AKABUTU, J. J</creator><creator>BOWEN, T</creator><general>American Association for Cancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>19980101</creationdate><title>Translocations involving chromosome 12p11-13, methotrexate metabolism, and outcome in childhood B-progenitor cell acute lymphoblastic leukemia: a Pediatric Oncology Group study</title><author>WHITEHEAD, V. M ; VUCHICH, M.-J ; KAMEN, B. A ; WATSON, M. S ; LOOK, A. T ; PULLEN, D. J ; CAMITTA, B ; COOLEY, L ; LAUER, S. J ; MAHONEY, D. H ; SHUSTER, J. J ; PAYMENT, C ; BERNSTEIN, M. L ; AKABUTU, J. J ; BOWEN, T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h266t-e5430e806a641c6f8f16a43e0f9b7c62a0f0294f619eea1dde9f821a892ac08b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Antimetabolites, Antineoplastic - metabolism</topic><topic>Antineoplastic agents</topic><topic>Biological and medical sciences</topic><topic>Chemotherapy</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Chromosomes, Human, Pair 12</topic><topic>DNA-Binding Proteins - genetics</topic><topic>ETS Translocation Variant 6 Protein</topic><topic>Female</topic><topic>Humans</topic><topic>Infant</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Methotrexate - metabolism</topic><topic>Pharmacology. Drug treatments</topic><topic>Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - genetics</topic><topic>Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics</topic><topic>Precursor Cell Lymphoblastic Leukemia-Lymphoma - metabolism</topic><topic>Proto-Oncogene Proteins c-ets</topic><topic>Repressor Proteins</topic><topic>Transcription Factors - genetics</topic><topic>Translocation, Genetic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>WHITEHEAD, V. M</creatorcontrib><creatorcontrib>VUCHICH, M.-J</creatorcontrib><creatorcontrib>KAMEN, B. A</creatorcontrib><creatorcontrib>WATSON, M. S</creatorcontrib><creatorcontrib>LOOK, A. T</creatorcontrib><creatorcontrib>PULLEN, D. J</creatorcontrib><creatorcontrib>CAMITTA, B</creatorcontrib><creatorcontrib>COOLEY, L</creatorcontrib><creatorcontrib>LAUER, S. J</creatorcontrib><creatorcontrib>MAHONEY, D. H</creatorcontrib><creatorcontrib>SHUSTER, J. J</creatorcontrib><creatorcontrib>PAYMENT, C</creatorcontrib><creatorcontrib>BERNSTEIN, M. L</creatorcontrib><creatorcontrib>AKABUTU, J. J</creatorcontrib><creatorcontrib>BOWEN, T</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Clinical cancer research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>WHITEHEAD, V. M</au><au>VUCHICH, M.-J</au><au>KAMEN, B. A</au><au>WATSON, M. S</au><au>LOOK, A. T</au><au>PULLEN, D. J</au><au>CAMITTA, B</au><au>COOLEY, L</au><au>LAUER, S. J</au><au>MAHONEY, D. H</au><au>SHUSTER, J. J</au><au>PAYMENT, C</au><au>BERNSTEIN, M. L</au><au>AKABUTU, J. J</au><au>BOWEN, T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Translocations involving chromosome 12p11-13, methotrexate metabolism, and outcome in childhood B-progenitor cell acute lymphoblastic leukemia: a Pediatric Oncology Group study</atitle><jtitle>Clinical cancer research</jtitle><addtitle>Clin Cancer Res</addtitle><date>1998-01-01</date><risdate>1998</risdate><volume>4</volume><issue>1</issue><spage>183</spage><epage>188</epage><pages>183-188</pages><issn>1078-0432</issn><eissn>1557-3265</eissn><abstract>Children with B-progenitor cell acute lymphoblastic leukemia whose lymphoblasts at diagnosis accumulate high levels of methotrexate
(MTX) and MTX polyglutamates (MTXPGs) appear to have a good prognosis. This has been attributed to increased sensitivity of
their blast cells to MTX. However, the proportion of children who are cured of B-progenitor cell acute lymphoblastic leukemia
exceeds the number whose lymphoblasts accumulate high MTXPG levels. We report that lymphoblasts from patients with < 50 chromosomes
who have translocations that involve the short arm of chromosome 12 accumulate low levels of MTXPGs. These patients appear
to have an excellent survival because none of 14 patients with translocations affecting 12p has relapsed, 26-79 months following
diagnosis.</abstract><cop>Philadelphia, PA</cop><pub>American Association for Cancer Research</pub><pmid>9516969</pmid><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1078-0432 |
| ispartof | Clinical cancer research, 1998-01, Vol.4 (1), p.183-188 |
| issn | 1078-0432 1557-3265 |
| language | eng |
| recordid | cdi_pubmed_primary_9516969 |
| source | MEDLINE; American Association for Cancer Research; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Antimetabolites, Antineoplastic - metabolism Antineoplastic agents Biological and medical sciences Chemotherapy Child Child, Preschool Chromosomes, Human, Pair 12 DNA-Binding Proteins - genetics ETS Translocation Variant 6 Protein Female Humans Infant Male Medical sciences Methotrexate - metabolism Pharmacology. Drug treatments Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - genetics Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics Precursor Cell Lymphoblastic Leukemia-Lymphoma - metabolism Proto-Oncogene Proteins c-ets Repressor Proteins Transcription Factors - genetics Translocation, Genetic |
| title | Translocations involving chromosome 12p11-13, methotrexate metabolism, and outcome in childhood B-progenitor cell acute lymphoblastic leukemia: a Pediatric Oncology Group study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-31T19%3A20%3A23IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed_pasca&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Translocations%20involving%20chromosome%2012p11-13,%20methotrexate%20metabolism,%20and%20outcome%20in%20childhood%20B-progenitor%20cell%20acute%20lymphoblastic%20leukemia:%20a%20Pediatric%20Oncology%20Group%20study&rft.jtitle=Clinical%20cancer%20research&rft.au=WHITEHEAD,%20V.%20M&rft.date=1998-01-01&rft.volume=4&rft.issue=1&rft.spage=183&rft.epage=188&rft.pages=183-188&rft.issn=1078-0432&rft.eissn=1557-3265&rft_id=info:doi/&rft_dat=%3Cpubmed_pasca%3E9516969%3C/pubmed_pasca%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/9516969&rfr_iscdi=true |