The Hering-Breuer reflex in anesthetized infants: end-inspiratory vs. end-expiratory occlusion technique
1 Department of Anaesthesia, Montreal Children's Hospital, Montreal, Quebec, Canada H3H 1P3; 2 Portex Anaesthesia, Intensive Therapy and Respiratory Medicine Unit, Institute of Child Health, London, WC1N 1EH, United Kingdom; and 3 Department of Anaesthesia and Intensive Care, The Chinese Uni...
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| Veröffentlicht in: | Journal of applied physiology (1985) 1998-04, Vol.84 (4), p.1437-1446 |
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| creator | Brown, K Stocks, J Aun, C Rabbette, P. S |
| description | 1 Department of Anaesthesia,
Montreal Children's Hospital, Montreal, Quebec, Canada H3H 1P3;
2 Portex Anaesthesia, Intensive
Therapy and Respiratory Medicine Unit, Institute of Child Health,
London, WC1N 1EH, United Kingdom; and
3 Department of Anaesthesia and
Intensive Care, The Chinese University of Hong Kong, Hong Kong,
People's Republic of China
Both
end-inspiratory (EIO) and end-expiratory (EEO) occlusions have been
used to measure the strength of the Hering-Breuer inflation reflex
(HBIR) in infants. The purpose of this study was to compare both
techniques in anesthetized infants. In each infant, HBIR activity was
calculated as the relative prolongation of expiratory and inspiratory
time during EIO and EEO, respectively. Respiratory drive was assessed
from the change in airway pressure during inspiratory effort against
the occlusion, both at a fixed time interval of 100 ms
(P 0.1 ) and a fixed proportion
(10%) of the occluded inspiratory time
(P 10% ). Twenty-two infants [age 14.3 ± 6.4 (SD) mo] were studied. No HBIR activity
was present during EIO [ 11.8 ± 15.9 (SD) %]. By
contrast, there was significant, albeit weak, reflex activity during
EEO [HBIR: 27.2 ± 17.4%]. A strong HBIR (up to 310%)
was elicited in six of seven infants in whom EIO was repeated after
lung inflation. P 0.1 was similar during both types of occlusions, whereas mean ± SD
P 10% was lower during EEO than
during EIO: 0.198 ± 0.09 vs. 0.367 ± 0.15 kPa, respectively
( P |
| doi_str_mv | 10.1152/jappl.1998.84.4.1437 |
| format | Article |
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Montreal Children's Hospital, Montreal, Quebec, Canada H3H 1P3;
2 Portex Anaesthesia, Intensive
Therapy and Respiratory Medicine Unit, Institute of Child Health,
London, WC1N 1EH, United Kingdom; and
3 Department of Anaesthesia and
Intensive Care, The Chinese University of Hong Kong, Hong Kong,
People's Republic of China
Both
end-inspiratory (EIO) and end-expiratory (EEO) occlusions have been
used to measure the strength of the Hering-Breuer inflation reflex
(HBIR) in infants. The purpose of this study was to compare both
techniques in anesthetized infants. In each infant, HBIR activity was
calculated as the relative prolongation of expiratory and inspiratory
time during EIO and EEO, respectively. Respiratory drive was assessed
from the change in airway pressure during inspiratory effort against
the occlusion, both at a fixed time interval of 100 ms
(P 0.1 ) and a fixed proportion
(10%) of the occluded inspiratory time
(P 10% ). Twenty-two infants [age 14.3 ± 6.4 (SD) mo] were studied. No HBIR activity
was present during EIO [ 11.8 ± 15.9 (SD) %]. By
contrast, there was significant, albeit weak, reflex activity during
EEO [HBIR: 27.2 ± 17.4%]. A strong HBIR (up to 310%)
was elicited in six of seven infants in whom EIO was repeated after
lung inflation. P 0.1 was similar during both types of occlusions, whereas mean ± SD
P 10% was lower during EEO than
during EIO: 0.198 ± 0.09 vs. 0.367 ± 0.15 kPa, respectively
( P < 0.01). These data suggest a
difference in the central integration of stretch receptor activity in
infants during anesthesia compared with during sleep.
healthy infants; halothane; sevoflurane; anesthesia; respiratory
drive; control of breathing; Hering-Breuer inflation reflex</description><identifier>ISSN: 8750-7587</identifier><identifier>EISSN: 1522-1601</identifier><identifier>DOI: 10.1152/jappl.1998.84.4.1437</identifier><identifier>PMID: 9516215</identifier><identifier>CODEN: JAPHEV</identifier><language>eng</language><publisher>Bethesda, MD: Am Physiological Soc</publisher><subject>Anesthesia ; Anesthesia, Inhalation ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Anesthetics, Inhalation ; Biological and medical sciences ; Double-Blind Method ; Forced Expiratory Flow Rates ; General anesthesia. Technics. Complications. Neuromuscular blocking. Premedication. Surgical preparation. Sedation ; Halothane ; Humans ; Infant ; Lung - physiology ; Lung Volume Measurements ; Medical sciences ; Methyl Ethers ; Reflex - physiology ; Respiration, Artificial ; Respiratory Function Tests - methods ; Respiratory Mechanics - physiology</subject><ispartof>Journal of applied physiology (1985), 1998-04, Vol.84 (4), p.1437-1446</ispartof><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c409t-d467af73db1c29cc45fd69909156bb519631a0fab20c8b6f62f65a574aab5be3</citedby><cites>FETCH-LOGICAL-c409t-d467af73db1c29cc45fd69909156bb519631a0fab20c8b6f62f65a574aab5be3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,3039,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2245350$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9516215$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Brown, K</creatorcontrib><creatorcontrib>Stocks, J</creatorcontrib><creatorcontrib>Aun, C</creatorcontrib><creatorcontrib>Rabbette, P. S</creatorcontrib><title>The Hering-Breuer reflex in anesthetized infants: end-inspiratory vs. end-expiratory occlusion technique</title><title>Journal of applied physiology (1985)</title><addtitle>J Appl Physiol (1985)</addtitle><description>1 Department of Anaesthesia,
Montreal Children's Hospital, Montreal, Quebec, Canada H3H 1P3;
2 Portex Anaesthesia, Intensive
Therapy and Respiratory Medicine Unit, Institute of Child Health,
London, WC1N 1EH, United Kingdom; and
3 Department of Anaesthesia and
Intensive Care, The Chinese University of Hong Kong, Hong Kong,
People's Republic of China
Both
end-inspiratory (EIO) and end-expiratory (EEO) occlusions have been
used to measure the strength of the Hering-Breuer inflation reflex
(HBIR) in infants. The purpose of this study was to compare both
techniques in anesthetized infants. In each infant, HBIR activity was
calculated as the relative prolongation of expiratory and inspiratory
time during EIO and EEO, respectively. Respiratory drive was assessed
from the change in airway pressure during inspiratory effort against
the occlusion, both at a fixed time interval of 100 ms
(P 0.1 ) and a fixed proportion
(10%) of the occluded inspiratory time
(P 10% ). Twenty-two infants [age 14.3 ± 6.4 (SD) mo] were studied. No HBIR activity
was present during EIO [ 11.8 ± 15.9 (SD) %]. By
contrast, there was significant, albeit weak, reflex activity during
EEO [HBIR: 27.2 ± 17.4%]. A strong HBIR (up to 310%)
was elicited in six of seven infants in whom EIO was repeated after
lung inflation. P 0.1 was similar during both types of occlusions, whereas mean ± SD
P 10% was lower during EEO than
during EIO: 0.198 ± 0.09 vs. 0.367 ± 0.15 kPa, respectively
( P < 0.01). These data suggest a
difference in the central integration of stretch receptor activity in
infants during anesthesia compared with during sleep.
healthy infants; halothane; sevoflurane; anesthesia; respiratory
drive; control of breathing; Hering-Breuer inflation reflex</description><subject>Anesthesia</subject><subject>Anesthesia, Inhalation</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Anesthetics, Inhalation</subject><subject>Biological and medical sciences</subject><subject>Double-Blind Method</subject><subject>Forced Expiratory Flow Rates</subject><subject>General anesthesia. Technics. Complications. Neuromuscular blocking. Premedication. Surgical preparation. Sedation</subject><subject>Halothane</subject><subject>Humans</subject><subject>Infant</subject><subject>Lung - physiology</subject><subject>Lung Volume Measurements</subject><subject>Medical sciences</subject><subject>Methyl Ethers</subject><subject>Reflex - physiology</subject><subject>Respiration, Artificial</subject><subject>Respiratory Function Tests - methods</subject><subject>Respiratory Mechanics - physiology</subject><issn>8750-7587</issn><issn>1522-1601</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE9v1DAQxS1EVZaWbwBSDghxSWon_hNzg6qlSJV62bvlOOONK68T7AR2-fT1tquFCyfLM-_Nm_kh9J7gihBWXz3qafIVkbKtWlrRitBGvEKr3KpLwjF5jVatYLgUrBVv0NuUHjEmlDJyjs4lI7wmbIWG9QDFHUQXNuW3CAvEIoL1sCtcKHSANA8wuz_Q57_VYU5fCgh96UKaXNTzGPfFr1Q912B3Ko3G-CW5MRQzmCG4nwtcojOrfYJ3x_cCrW9v1td35f3D9x_XX-9LQ7Gcy55yoa1o-o6YWhpDme25lFgSxruOEckborHVXY1N23HLa8uZZoJq3bEOmgv06WXsFMecmma1dcmA9_mWcUlKSEFlw3kW0hehiWNK-WY1RbfVca8IVge-6pmvOvBVLVVUHfhm24fj_KXbQn8yHYHm_sdjXyejvY06GJdOsrqmrGH4b_rgNsNvF0FNwz4D8-Nmr24X79ewmw8bnJLV1Nts-_x_W1b_s-gTMs6oFQ</recordid><startdate>19980401</startdate><enddate>19980401</enddate><creator>Brown, K</creator><creator>Stocks, J</creator><creator>Aun, C</creator><creator>Rabbette, P. S</creator><general>Am Physiological Soc</general><general>American Physiological Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19980401</creationdate><title>The Hering-Breuer reflex in anesthetized infants: end-inspiratory vs. end-expiratory occlusion technique</title><author>Brown, K ; Stocks, J ; Aun, C ; Rabbette, P. S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c409t-d467af73db1c29cc45fd69909156bb519631a0fab20c8b6f62f65a574aab5be3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Anesthesia</topic><topic>Anesthesia, Inhalation</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Anesthetics, Inhalation</topic><topic>Biological and medical sciences</topic><topic>Double-Blind Method</topic><topic>Forced Expiratory Flow Rates</topic><topic>General anesthesia. Technics. Complications. Neuromuscular blocking. Premedication. Surgical preparation. Sedation</topic><topic>Halothane</topic><topic>Humans</topic><topic>Infant</topic><topic>Lung - physiology</topic><topic>Lung Volume Measurements</topic><topic>Medical sciences</topic><topic>Methyl Ethers</topic><topic>Reflex - physiology</topic><topic>Respiration, Artificial</topic><topic>Respiratory Function Tests - methods</topic><topic>Respiratory Mechanics - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Brown, K</creatorcontrib><creatorcontrib>Stocks, J</creatorcontrib><creatorcontrib>Aun, C</creatorcontrib><creatorcontrib>Rabbette, P. S</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of applied physiology (1985)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Brown, K</au><au>Stocks, J</au><au>Aun, C</au><au>Rabbette, P. S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Hering-Breuer reflex in anesthetized infants: end-inspiratory vs. end-expiratory occlusion technique</atitle><jtitle>Journal of applied physiology (1985)</jtitle><addtitle>J Appl Physiol (1985)</addtitle><date>1998-04-01</date><risdate>1998</risdate><volume>84</volume><issue>4</issue><spage>1437</spage><epage>1446</epage><pages>1437-1446</pages><issn>8750-7587</issn><eissn>1522-1601</eissn><coden>JAPHEV</coden><abstract>1 Department of Anaesthesia,
Montreal Children's Hospital, Montreal, Quebec, Canada H3H 1P3;
2 Portex Anaesthesia, Intensive
Therapy and Respiratory Medicine Unit, Institute of Child Health,
London, WC1N 1EH, United Kingdom; and
3 Department of Anaesthesia and
Intensive Care, The Chinese University of Hong Kong, Hong Kong,
People's Republic of China
Both
end-inspiratory (EIO) and end-expiratory (EEO) occlusions have been
used to measure the strength of the Hering-Breuer inflation reflex
(HBIR) in infants. The purpose of this study was to compare both
techniques in anesthetized infants. In each infant, HBIR activity was
calculated as the relative prolongation of expiratory and inspiratory
time during EIO and EEO, respectively. Respiratory drive was assessed
from the change in airway pressure during inspiratory effort against
the occlusion, both at a fixed time interval of 100 ms
(P 0.1 ) and a fixed proportion
(10%) of the occluded inspiratory time
(P 10% ). Twenty-two infants [age 14.3 ± 6.4 (SD) mo] were studied. No HBIR activity
was present during EIO [ 11.8 ± 15.9 (SD) %]. By
contrast, there was significant, albeit weak, reflex activity during
EEO [HBIR: 27.2 ± 17.4%]. A strong HBIR (up to 310%)
was elicited in six of seven infants in whom EIO was repeated after
lung inflation. P 0.1 was similar during both types of occlusions, whereas mean ± SD
P 10% was lower during EEO than
during EIO: 0.198 ± 0.09 vs. 0.367 ± 0.15 kPa, respectively
( P < 0.01). These data suggest a
difference in the central integration of stretch receptor activity in
infants during anesthesia compared with during sleep.
healthy infants; halothane; sevoflurane; anesthesia; respiratory
drive; control of breathing; Hering-Breuer inflation reflex</abstract><cop>Bethesda, MD</cop><pub>Am Physiological Soc</pub><pmid>9516215</pmid><doi>10.1152/jappl.1998.84.4.1437</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Journal of applied physiology (1985), 1998-04, Vol.84 (4), p.1437-1446 |
| issn | 8750-7587 1522-1601 |
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| source | MEDLINE; American Physiological Society; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Anesthesia Anesthesia, Inhalation Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Anesthetics, Inhalation Biological and medical sciences Double-Blind Method Forced Expiratory Flow Rates General anesthesia. Technics. Complications. Neuromuscular blocking. Premedication. Surgical preparation. Sedation Halothane Humans Infant Lung - physiology Lung Volume Measurements Medical sciences Methyl Ethers Reflex - physiology Respiration, Artificial Respiratory Function Tests - methods Respiratory Mechanics - physiology |
| title | The Hering-Breuer reflex in anesthetized infants: end-inspiratory vs. end-expiratory occlusion technique |
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