Rat tibial nerve regeneration after postoperative administration of cis-diaminedichloroplatinum
We investigated the results of postoperative administration of cis-diaminedichloroplatinum on nerve regeneration in rats. Forty-two Lewis rats were divided into two groups, receiving end-to-end suture or nerve grafting. Subgroups of the suture group included control, a one-time dose of cis-diaminedi...
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| Veröffentlicht in: | Plastic and reconstructive surgery (1963) 1998-04, Vol.101 (4), p.1039-1044 |
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| container_title | Plastic and reconstructive surgery (1963) |
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| creator | SHIRAISHI, E SHIBATA, M TAKAHASHI, H. E |
| description | We investigated the results of postoperative administration of cis-diaminedichloroplatinum on nerve regeneration in rats. Forty-two Lewis rats were divided into two groups, receiving end-to-end suture or nerve grafting. Subgroups of the suture group included control, a one-time dose of cis-diaminedichloroplatinum (3 mg/kg), and four doses of the same amount of cis-diaminedichloroplatinum. Subgroups in the nerve grafting group included a control and a four-dose group. Functional recovery was measured by gait analysis using the tibial function index. Biopsies of nerve were taken distal to the suture site for histologic evaluation 20 weeks postoperatively. Tibial function index at 4, 6, and 20 postoperative weeks in the four-dose group was significantly inferior to that of the control group in the suture group. Tibial function index was inferior in the four-dose group until 10 weeks postoperatively compared with control in the nerve grafting group; however, there was no significant difference. The percentage of neural tissue in the one-dose suture group was significantly greater than in the four-dose suture group. These results suggest that postoperative cis-diaminedichloroplatinum administration may have a detrimental effect on nerve regeneration. |
| doi_str_mv | 10.1097/00006534-199804040-00023 |
| format | Article |
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E</creator><creatorcontrib>SHIRAISHI, E ; SHIBATA, M ; TAKAHASHI, H. E</creatorcontrib><description>We investigated the results of postoperative administration of cis-diaminedichloroplatinum on nerve regeneration in rats. Forty-two Lewis rats were divided into two groups, receiving end-to-end suture or nerve grafting. Subgroups of the suture group included control, a one-time dose of cis-diaminedichloroplatinum (3 mg/kg), and four doses of the same amount of cis-diaminedichloroplatinum. Subgroups in the nerve grafting group included a control and a four-dose group. Functional recovery was measured by gait analysis using the tibial function index. Biopsies of nerve were taken distal to the suture site for histologic evaluation 20 weeks postoperatively. Tibial function index at 4, 6, and 20 postoperative weeks in the four-dose group was significantly inferior to that of the control group in the suture group. Tibial function index was inferior in the four-dose group until 10 weeks postoperatively compared with control in the nerve grafting group; however, there was no significant difference. The percentage of neural tissue in the one-dose suture group was significantly greater than in the four-dose suture group. These results suggest that postoperative cis-diaminedichloroplatinum administration may have a detrimental effect on nerve regeneration.</description><identifier>ISSN: 0032-1052</identifier><identifier>EISSN: 1529-4242</identifier><identifier>DOI: 10.1097/00006534-199804040-00023</identifier><identifier>PMID: 9514338</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Anastomosis, Surgical ; Animals ; Antineoplastic Agents - pharmacokinetics ; Antineoplastic Agents - toxicity ; Biological and medical sciences ; Body Weight - drug effects ; Cisplatin - pharmacokinetics ; Cisplatin - toxicity ; Male ; Medical sciences ; Miscellaneous ; Nerve Regeneration - drug effects ; Neural Conduction ; Neuropharmacology ; Pharmacology. Drug treatments ; Rats ; Rats, Inbred Lew ; Sutures ; Tibial Nerve - pathology ; Tibial Nerve - physiology ; Tibial Nerve - surgery</subject><ispartof>Plastic and reconstructive surgery (1963), 1998-04, Vol.101 (4), p.1039-1044</ispartof><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2183978$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9514338$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SHIRAISHI, E</creatorcontrib><creatorcontrib>SHIBATA, M</creatorcontrib><creatorcontrib>TAKAHASHI, H. E</creatorcontrib><title>Rat tibial nerve regeneration after postoperative administration of cis-diaminedichloroplatinum</title><title>Plastic and reconstructive surgery (1963)</title><addtitle>Plast Reconstr Surg</addtitle><description>We investigated the results of postoperative administration of cis-diaminedichloroplatinum on nerve regeneration in rats. Forty-two Lewis rats were divided into two groups, receiving end-to-end suture or nerve grafting. Subgroups of the suture group included control, a one-time dose of cis-diaminedichloroplatinum (3 mg/kg), and four doses of the same amount of cis-diaminedichloroplatinum. Subgroups in the nerve grafting group included a control and a four-dose group. Functional recovery was measured by gait analysis using the tibial function index. Biopsies of nerve were taken distal to the suture site for histologic evaluation 20 weeks postoperatively. Tibial function index at 4, 6, and 20 postoperative weeks in the four-dose group was significantly inferior to that of the control group in the suture group. Tibial function index was inferior in the four-dose group until 10 weeks postoperatively compared with control in the nerve grafting group; however, there was no significant difference. The percentage of neural tissue in the one-dose suture group was significantly greater than in the four-dose suture group. These results suggest that postoperative cis-diaminedichloroplatinum administration may have a detrimental effect on nerve regeneration.</description><subject>Anastomosis, Surgical</subject><subject>Animals</subject><subject>Antineoplastic Agents - pharmacokinetics</subject><subject>Antineoplastic Agents - toxicity</subject><subject>Biological and medical sciences</subject><subject>Body Weight - drug effects</subject><subject>Cisplatin - pharmacokinetics</subject><subject>Cisplatin - toxicity</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Miscellaneous</subject><subject>Nerve Regeneration - drug effects</subject><subject>Neural Conduction</subject><subject>Neuropharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Rats</subject><subject>Rats, Inbred Lew</subject><subject>Sutures</subject><subject>Tibial Nerve - pathology</subject><subject>Tibial Nerve - physiology</subject><subject>Tibial Nerve - surgery</subject><issn>0032-1052</issn><issn>1529-4242</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9j8tKBDEQRYMo4zj6CUIv3EZTeXRXljL4ggFBdD0k3YlG-kWSEfx7gzZWLaq451LUJaQCdg1MNzesVK2EpKA1MlmaFoWLI7IGxTWVXPJjsmZMcApM8VNyltInY9CIWq3ISiuQQuCa7F9MrnKwwfTV6OKXq6J7d2UzOUxjZXx2sZqnlKf5VysG0w1hDCkvlslXbUi0C6bIrgvtRz_Fae4LHQ_DOTnxpk_uYpkb8nZ_97p9pLvnh6ft7Y7OXKhMESV6poXztnEcBXgw3KL2qq2ttCWybJTmLXjEDkEhNi3UdQ3KKie9FRty-Xd3PtjBdfs5hsHE7_0StPCrhZvUmt5HM5av_20cUOgGxQ8_8GUk</recordid><startdate>19980401</startdate><enddate>19980401</enddate><creator>SHIRAISHI, E</creator><creator>SHIBATA, M</creator><creator>TAKAHASHI, H. E</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>19980401</creationdate><title>Rat tibial nerve regeneration after postoperative administration of cis-diaminedichloroplatinum</title><author>SHIRAISHI, E ; SHIBATA, M ; TAKAHASHI, H. E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p235t-8848f093efb7e2831f1a2b89f5c6b4b09747592c1f88d815887c166615b5e4fb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Anastomosis, Surgical</topic><topic>Animals</topic><topic>Antineoplastic Agents - pharmacokinetics</topic><topic>Antineoplastic Agents - toxicity</topic><topic>Biological and medical sciences</topic><topic>Body Weight - drug effects</topic><topic>Cisplatin - pharmacokinetics</topic><topic>Cisplatin - toxicity</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Miscellaneous</topic><topic>Nerve Regeneration - drug effects</topic><topic>Neural Conduction</topic><topic>Neuropharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Rats</topic><topic>Rats, Inbred Lew</topic><topic>Sutures</topic><topic>Tibial Nerve - pathology</topic><topic>Tibial Nerve - physiology</topic><topic>Tibial Nerve - surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SHIRAISHI, E</creatorcontrib><creatorcontrib>SHIBATA, M</creatorcontrib><creatorcontrib>TAKAHASHI, H. E</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Plastic and reconstructive surgery (1963)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SHIRAISHI, E</au><au>SHIBATA, M</au><au>TAKAHASHI, H. E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Rat tibial nerve regeneration after postoperative administration of cis-diaminedichloroplatinum</atitle><jtitle>Plastic and reconstructive surgery (1963)</jtitle><addtitle>Plast Reconstr Surg</addtitle><date>1998-04-01</date><risdate>1998</risdate><volume>101</volume><issue>4</issue><spage>1039</spage><epage>1044</epage><pages>1039-1044</pages><issn>0032-1052</issn><eissn>1529-4242</eissn><abstract>We investigated the results of postoperative administration of cis-diaminedichloroplatinum on nerve regeneration in rats. Forty-two Lewis rats were divided into two groups, receiving end-to-end suture or nerve grafting. Subgroups of the suture group included control, a one-time dose of cis-diaminedichloroplatinum (3 mg/kg), and four doses of the same amount of cis-diaminedichloroplatinum. Subgroups in the nerve grafting group included a control and a four-dose group. Functional recovery was measured by gait analysis using the tibial function index. Biopsies of nerve were taken distal to the suture site for histologic evaluation 20 weeks postoperatively. Tibial function index at 4, 6, and 20 postoperative weeks in the four-dose group was significantly inferior to that of the control group in the suture group. Tibial function index was inferior in the four-dose group until 10 weeks postoperatively compared with control in the nerve grafting group; however, there was no significant difference. The percentage of neural tissue in the one-dose suture group was significantly greater than in the four-dose suture group. These results suggest that postoperative cis-diaminedichloroplatinum administration may have a detrimental effect on nerve regeneration.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>9514338</pmid><doi>10.1097/00006534-199804040-00023</doi><tpages>6</tpages></addata></record> |
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| identifier | ISSN: 0032-1052 |
| ispartof | Plastic and reconstructive surgery (1963), 1998-04, Vol.101 (4), p.1039-1044 |
| issn | 0032-1052 1529-4242 |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Anastomosis, Surgical Animals Antineoplastic Agents - pharmacokinetics Antineoplastic Agents - toxicity Biological and medical sciences Body Weight - drug effects Cisplatin - pharmacokinetics Cisplatin - toxicity Male Medical sciences Miscellaneous Nerve Regeneration - drug effects Neural Conduction Neuropharmacology Pharmacology. Drug treatments Rats Rats, Inbred Lew Sutures Tibial Nerve - pathology Tibial Nerve - physiology Tibial Nerve - surgery |
| title | Rat tibial nerve regeneration after postoperative administration of cis-diaminedichloroplatinum |
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