Pseudomonas aeruginosa protease IV produces corneal damage and contributes to bacterial virulence

A Pseudomonas mutant deficient in protease IV has significantly reduced virulence in experimental keratitis. In the present study, the corneal toxicity of purified protease IV and its ability to augment the virulence of protease-IV-deficient bacteria were analyzed. The toxicity of purified protease...

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Veröffentlicht in:	Investigative ophthalmology & visual science 1998-03, Vol.39 (3), p.662-665
Hauptverfasser:	Engel, LS, Hill, JM, Moreau, JM, Green, LC, Hobden, JA, O'Callaghan, RJ
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bacterial diseases Biological and medical sciences Colony Count, Microbial Cornea - drug effects Cornea - microbiology Cornea - pathology Corneal Ulcer - chemically induced Corneal Ulcer - microbiology Corneal Ulcer - pathology Experimental bacterial diseases and models Eye Infections, Bacterial - chemically induced Eye Infections, Bacterial - microbiology Eye Infections, Bacterial - pathology Infectious diseases Medical sciences Peptide Hydrolases - isolation & purification Peptide Hydrolases - pharmacology Pseudomonas aeruginosa - chemistry Pseudomonas aeruginosa - enzymology Pseudomonas aeruginosa - pathogenicity Pseudomonas Infections - chemically induced Pseudomonas Infections - microbiology Pseudomonas Infections - pathology Rabbits Virulence
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