Stabilization and Activation of p53 are Regulated Independently by Different Phosphorylation Events

Treatment of mouse or human cells with the protein kinase C (PKC) inhibitors H7 or bisindolylmaleimide I induced an increase in the lifetime of p53, leading to its accumulation. In inhibitor-treated cells, p53 translocated to the nuclei and bound to DNA but was not competent to induce transcription....

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1998-03, Vol.95 (5), p.2284-2289
Hauptverfasser:	Chernov, Mikhail V., Ramana, Chilakamarti V., Adler, Victor V., Stark, George R.
Format:	Artikel
Sprache:	eng
Schlagworte:	1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - pharmacology Amino Acid Sequence Animals Biological Sciences Cell Line Cell lines Cell nucleus Cell Nucleus - metabolism Cells Cellular biology Deoxyribonucleic acid DNA DNA damage Doxorubicin - pharmacology Enzyme Inhibitors - pharmacology Enzymes Gene expression regulation HeLa cells Humans Indoles - pharmacology Kinetics Maleimides - pharmacology Mice Molecular Sequence Data Peptide Fragments - chemistry Phorbol esters Phosphorylation Protein Kinase C - antagonists & inhibitors Proteins Recombinant Fusion Proteins - biosynthesis Recombinant Fusion Proteins - chemistry Recombinant Fusion Proteins - metabolism RNA, Messenger - biosynthesis Tetradecanoylphorbol Acetate - pharmacology Transcription, Genetic - drug effects Transcription, Genetic - radiation effects Transfection Tumor Suppressor Protein p53 - biosynthesis Tumor Suppressor Protein p53 - chemistry Tumor Suppressor Protein p53 - metabolism Ultraviolet Rays
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