Sleep apnea in obese miniature pigs
1 Pulmonary and Critical Care Medicine, University of Virginia Medical Center, Charlottesville 22908; 2 Department of Psychiatry and Behavioral Science, Eastern Virginia Medical School, Norfolk 23507; 3 Division of Endocrinology, Hampton Veterans Affairs Hospital, Hampton, Virginia 23667 Lonergan...
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| Veröffentlicht in: | Journal of applied physiology (1985) 1998-02, Vol.84 (2), p.531-536 |
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| container_title | Journal of applied physiology (1985) |
| container_volume | 84 |
| creator | Lonergan III, Robert P Ware, J. Catsby Atkinson, Richard L Winter, W. Christopher Suratt, Paul M |
| description | 1 Pulmonary and Critical Care
Medicine, University of Virginia Medical Center, Charlottesville
22908; 2 Department of Psychiatry
and Behavioral Science, Eastern Virginia Medical School, Norfolk
23507; 3 Division of
Endocrinology, Hampton Veterans Affairs Hospital, Hampton, Virginia
23667
Lonergan, Robert P., III, J. Catsby Ware, Richard L. Atkinson, W. Christopher Winter, and Paul M. Suratt. Sleep apnea in obese miniature pigs. J. Appl.
Physiol. 84(2): 531-536, 1998. We postulated that
three extremely obese Yucatan miniature pigs would have more sleep
apnea than three nonobese Yucatan miniature pigs. Pigs were studied
with the use of electroencephalograms, inductance plethysmography,
oximetry, expired nasal CO 2 , or
thermistors. All of the obese pigs, but none of the nonobese pigs, had
both sleep apnea (8.5, 10.3, and 97.0 in obese pigs vs. 0 apnea + hypopnea/h in all nonobese pigs; P |
| doi_str_mv | 10.1152/jappl.1998.84.2.531 |
| format | Article |
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Medicine, University of Virginia Medical Center, Charlottesville
22908; 2 Department of Psychiatry
and Behavioral Science, Eastern Virginia Medical School, Norfolk
23507; 3 Division of
Endocrinology, Hampton Veterans Affairs Hospital, Hampton, Virginia
23667
Lonergan, Robert P., III, J. Catsby Ware, Richard L. Atkinson, W. Christopher Winter, and Paul M. Suratt. Sleep apnea in obese miniature pigs. J. Appl.
Physiol. 84(2): 531-536, 1998. We postulated that
three extremely obese Yucatan miniature pigs would have more sleep
apnea than three nonobese Yucatan miniature pigs. Pigs were studied
with the use of electroencephalograms, inductance plethysmography,
oximetry, expired nasal CO 2 , or
thermistors. All of the obese pigs, but none of the nonobese pigs, had
both sleep apnea (8.5, 10.3, and 97.0 in obese pigs vs. 0 apnea + hypopnea/h in all nonobese pigs; P < 0.05) and oxyhemoglobin desaturation episodes during sleep [9.4 ± 3.0 vs. 0 + 0.53 (SD) mean desaturation episodes/h in obese pigs
vs. nonobese pigs, respectively; P < 0.05]. Two of the extremely obese pigs had obstructive sleep
apnea, whereas the third obese pig had central sleep apnea. We conclude that sleep apnea occurs in extremely obese Yucatan minipigs and suggest
that this animal can be used as a model for sleep apnea in obesity.
obstructive sleep apnea; central sleep apnea; obesity
The Journal of Applied Physiology 84(2):531-536</description><identifier>ISSN: 8750-7587</identifier><identifier>EISSN: 1522-1601</identifier><identifier>DOI: 10.1152/jappl.1998.84.2.531</identifier><identifier>PMID: 9475862</identifier><identifier>CODEN: JAPHEV</identifier><language>eng</language><publisher>Bethesda, MD: Am Physiological Soc</publisher><subject>Animals ; Biological and medical sciences ; Electroencephalography ; Female ; Medical sciences ; Metabolic diseases ; Obesity ; Obesity - blood ; Obesity - complications ; Obesity - physiopathology ; Oxyhemoglobins - analysis ; Sleep Apnea Syndromes - blood ; Sleep Apnea Syndromes - etiology ; Sleep Apnea Syndromes - physiopathology ; Sleep Stages ; Swine ; Swine, Miniature</subject><ispartof>Journal of applied physiology (1985), 1998-02, Vol.84 (2), p.531-536</ispartof><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c516t-3d18f9fdca7e2d13a92c58ae2cd996d2382cb98a0b0552c219183855dd3d01b83</citedby><cites>FETCH-LOGICAL-c516t-3d18f9fdca7e2d13a92c58ae2cd996d2382cb98a0b0552c219183855dd3d01b83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3026,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2209357$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9475862$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lonergan III, Robert P</creatorcontrib><creatorcontrib>Ware, J. Catsby</creatorcontrib><creatorcontrib>Atkinson, Richard L</creatorcontrib><creatorcontrib>Winter, W. Christopher</creatorcontrib><creatorcontrib>Suratt, Paul M</creatorcontrib><title>Sleep apnea in obese miniature pigs</title><title>Journal of applied physiology (1985)</title><addtitle>J Appl Physiol (1985)</addtitle><description>1 Pulmonary and Critical Care
Medicine, University of Virginia Medical Center, Charlottesville
22908; 2 Department of Psychiatry
and Behavioral Science, Eastern Virginia Medical School, Norfolk
23507; 3 Division of
Endocrinology, Hampton Veterans Affairs Hospital, Hampton, Virginia
23667
Lonergan, Robert P., III, J. Catsby Ware, Richard L. Atkinson, W. Christopher Winter, and Paul M. Suratt. Sleep apnea in obese miniature pigs. J. Appl.
Physiol. 84(2): 531-536, 1998. We postulated that
three extremely obese Yucatan miniature pigs would have more sleep
apnea than three nonobese Yucatan miniature pigs. Pigs were studied
with the use of electroencephalograms, inductance plethysmography,
oximetry, expired nasal CO 2 , or
thermistors. All of the obese pigs, but none of the nonobese pigs, had
both sleep apnea (8.5, 10.3, and 97.0 in obese pigs vs. 0 apnea + hypopnea/h in all nonobese pigs; P < 0.05) and oxyhemoglobin desaturation episodes during sleep [9.4 ± 3.0 vs. 0 + 0.53 (SD) mean desaturation episodes/h in obese pigs
vs. nonobese pigs, respectively; P < 0.05]. Two of the extremely obese pigs had obstructive sleep
apnea, whereas the third obese pig had central sleep apnea. We conclude that sleep apnea occurs in extremely obese Yucatan minipigs and suggest
that this animal can be used as a model for sleep apnea in obesity.
obstructive sleep apnea; central sleep apnea; obesity
The Journal of Applied Physiology 84(2):531-536</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Electroencephalography</subject><subject>Female</subject><subject>Medical sciences</subject><subject>Metabolic diseases</subject><subject>Obesity</subject><subject>Obesity - blood</subject><subject>Obesity - complications</subject><subject>Obesity - physiopathology</subject><subject>Oxyhemoglobins - analysis</subject><subject>Sleep Apnea Syndromes - blood</subject><subject>Sleep Apnea Syndromes - etiology</subject><subject>Sleep Apnea Syndromes - physiopathology</subject><subject>Sleep Stages</subject><subject>Swine</subject><subject>Swine, Miniature</subject><issn>8750-7587</issn><issn>1522-1601</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kF9LwzAUxYMoc04_gQgFRZ9a86dpk0cZToWBD87nkCbplpG2sVnRfXs7V92TTxfuOefeww-ASwQThCi-X0vvXYI4ZwlLE5xQgo7AuFdwjDKIjsGY5RTGOWX5KTgLYQ0hSlOKRmDE036b4TG4fnPG-Ej62sjI1lFTmGCiytZWbrrWRN4uwzk4KaUL5mKYE_A-e1xMn-P569PL9GEeK4qyTUw0YiUvtZK5wRoRybGiTBqsNOeZxoRhVXAmYQEpxQojjhhhlGpNNEQFIxNwu7_r2-ajM2EjKhuUcU7WpumCyHnGOMlhbyR7o2qbEFpTCt_aSrZbgaDYoRE_aMQOjWCpwKJH06euhvNdURn9lxlY9PrNoMugpCtbWSsb_mwYQ05ofni-ssvVp22N8KttsI1rllsx65xbmK_NrsDvY-F12afu_k_15kPNb-RzjHQ</recordid><startdate>19980201</startdate><enddate>19980201</enddate><creator>Lonergan III, Robert P</creator><creator>Ware, J. Catsby</creator><creator>Atkinson, Richard L</creator><creator>Winter, W. Christopher</creator><creator>Suratt, Paul M</creator><general>Am Physiological Soc</general><general>American Physiological Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19980201</creationdate><title>Sleep apnea in obese miniature pigs</title><author>Lonergan III, Robert P ; Ware, J. Catsby ; Atkinson, Richard L ; Winter, W. Christopher ; Suratt, Paul M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c516t-3d18f9fdca7e2d13a92c58ae2cd996d2382cb98a0b0552c219183855dd3d01b83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Electroencephalography</topic><topic>Female</topic><topic>Medical sciences</topic><topic>Metabolic diseases</topic><topic>Obesity</topic><topic>Obesity - blood</topic><topic>Obesity - complications</topic><topic>Obesity - physiopathology</topic><topic>Oxyhemoglobins - analysis</topic><topic>Sleep Apnea Syndromes - blood</topic><topic>Sleep Apnea Syndromes - etiology</topic><topic>Sleep Apnea Syndromes - physiopathology</topic><topic>Sleep Stages</topic><topic>Swine</topic><topic>Swine, Miniature</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lonergan III, Robert P</creatorcontrib><creatorcontrib>Ware, J. Catsby</creatorcontrib><creatorcontrib>Atkinson, Richard L</creatorcontrib><creatorcontrib>Winter, W. Christopher</creatorcontrib><creatorcontrib>Suratt, Paul M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of applied physiology (1985)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lonergan III, Robert P</au><au>Ware, J. Catsby</au><au>Atkinson, Richard L</au><au>Winter, W. Christopher</au><au>Suratt, Paul M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sleep apnea in obese miniature pigs</atitle><jtitle>Journal of applied physiology (1985)</jtitle><addtitle>J Appl Physiol (1985)</addtitle><date>1998-02-01</date><risdate>1998</risdate><volume>84</volume><issue>2</issue><spage>531</spage><epage>536</epage><pages>531-536</pages><issn>8750-7587</issn><eissn>1522-1601</eissn><coden>JAPHEV</coden><abstract>1 Pulmonary and Critical Care
Medicine, University of Virginia Medical Center, Charlottesville
22908; 2 Department of Psychiatry
and Behavioral Science, Eastern Virginia Medical School, Norfolk
23507; 3 Division of
Endocrinology, Hampton Veterans Affairs Hospital, Hampton, Virginia
23667
Lonergan, Robert P., III, J. Catsby Ware, Richard L. Atkinson, W. Christopher Winter, and Paul M. Suratt. Sleep apnea in obese miniature pigs. J. Appl.
Physiol. 84(2): 531-536, 1998. We postulated that
three extremely obese Yucatan miniature pigs would have more sleep
apnea than three nonobese Yucatan miniature pigs. Pigs were studied
with the use of electroencephalograms, inductance plethysmography,
oximetry, expired nasal CO 2 , or
thermistors. All of the obese pigs, but none of the nonobese pigs, had
both sleep apnea (8.5, 10.3, and 97.0 in obese pigs vs. 0 apnea + hypopnea/h in all nonobese pigs; P < 0.05) and oxyhemoglobin desaturation episodes during sleep [9.4 ± 3.0 vs. 0 + 0.53 (SD) mean desaturation episodes/h in obese pigs
vs. nonobese pigs, respectively; P < 0.05]. Two of the extremely obese pigs had obstructive sleep
apnea, whereas the third obese pig had central sleep apnea. We conclude that sleep apnea occurs in extremely obese Yucatan minipigs and suggest
that this animal can be used as a model for sleep apnea in obesity.
obstructive sleep apnea; central sleep apnea; obesity
The Journal of Applied Physiology 84(2):531-536</abstract><cop>Bethesda, MD</cop><pub>Am Physiological Soc</pub><pmid>9475862</pmid><doi>10.1152/jappl.1998.84.2.531</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of applied physiology (1985), 1998-02, Vol.84 (2), p.531-536 |
| issn | 8750-7587 1522-1601 |
| language | eng |
| recordid | cdi_pubmed_primary_9475862 |
| source | MEDLINE; American Physiological Society Paid; Alma/SFX Local Collection; EZB Electronic Journals Library |
| subjects | Animals Biological and medical sciences Electroencephalography Female Medical sciences Metabolic diseases Obesity Obesity - blood Obesity - complications Obesity - physiopathology Oxyhemoglobins - analysis Sleep Apnea Syndromes - blood Sleep Apnea Syndromes - etiology Sleep Apnea Syndromes - physiopathology Sleep Stages Swine Swine, Miniature |
| title | Sleep apnea in obese miniature pigs |
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