Bcl-2 Prevents Apoptotic Mitochondrial Dysfunction by Regulating Proton Flux

We and others have recently shown that loss of the mitochondrial membrane potential (Δ ψ ) precedes apoptosis and chemical-hypoxia-induced necrosis and is prevented by Bcl-2. In this report, we examine the biochemical mechanism used by Bcl-2 to prevent Δ ψ loss, as determined with mitochondria isola...

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