N-acetyl cysteine attenuates acute lung injury in the rat

The development of the adult respiratory distress syndrome (ARDS) in the critically ill patient is associated with a significant morbidity and mortality. The pulmonary dysfunction in ARDS is largely secondary to neutrophil-mediated oxidant injury. The purpose of these studies is to examine the effec...

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Veröffentlicht in:	Shock (Augusta, Ga.) Ga.), 1997-12, Vol.8 (6), p.432
Hauptverfasser:	Davreux, C J, Soric, I, Nathens, A B, Watson, R W, McGilvray, I D, Suntres, Z E, Shek, P N, Rotstein, O D
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcysteine - therapeutic use Acute Disease Animals Antioxidants - therapeutic use Bronchoalveolar Lavage Fluid - cytology Bronchoalveolar Lavage Fluid - immunology Capillary Permeability - drug effects CD11 Antigens - blood CD11 Antigens - drug effects Cell Count - drug effects Disease Models, Animal Dose-Response Relationship, Drug Endotoxins - toxicity Glutathione - analysis Glutathione - drug effects Hemorrhage - chemically induced Lipid Peroxidation - drug effects Lipopolysaccharides - pharmacology Liver - chemistry Lung - chemistry Lung - drug effects Lung Diseases - chemically induced Lung Diseases - drug therapy Lung Diseases - prevention & control Lung Injury Male Neutrophil Activation - drug effects Neutrophils - drug effects Neutrophils - immunology Neutrophils - metabolism Peroxidase - drug effects Peroxidase - metabolism Pulmonary Edema - chemically induced Rats Rats, Sprague-Dawley Tumor Necrosis Factor-alpha - drug effects Tumor Necrosis Factor-alpha - metabolism
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