Two Sterol Regulatory Element-Like Sequences Mediate up-Regulation of Caveolin Gene Transcription in Response to Low Density Lipoprotein Free Cholesterol

Caveolae form the terminus for a major pathway of intracellular free cholesterol (FC) transport. Caveolin mRNA levels in confluent human skin fibroblasts were up-regulated following increased uptake of low density lipoprotein (LDL) FC. The increase induced by FC was not associated with detectable ch...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1997-09, Vol.94 (20), p.10693-10698
Hauptverfasser:	Bist, Anita, Fielding, Phoebe E., Fielding, Christopher J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Biochemistry Biological Sciences Caveolin 1 Caveolins CCAAT-Enhancer-Binding Proteins Cells Cells, Cultured Cholesterol Cholesterol, LDL - physiology Cholesterols DNA DNA Footprinting DNA probes DNA-Binding Proteins - genetics Fibroblasts Gels Genes Helix-Loop-Helix Motifs Humans Membrane Proteins - genetics Messenger RNA Molecular Sequence Data Mutagenesis Nuclear Proteins - genetics Promoter regions Promoter Regions, Genetic Proteins Sequence Deletion Sterol Regulatory Element Binding Protein 1 Transcription Factors Transcription, Genetic Up-Regulation
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