Age-related negative associations between parameters of cytogenetic damage and ex vivo (+/-)-anti-benzo(a)pyrene diolepoxide-induced unscheduled DNA synthesis in smoking humans
Chemical or physical modification of DNA may cause an increase in genomic mutations or other genetic alterations, which may ultimately result in the onset of cancer. To avoid these deleterious effects of DNA damage, humans possess DNA repair mechanisms. Decreased DNA repair, induced ex vivo by UV li...
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| Veröffentlicht in: | Cancer epidemiology, biomarkers & prevention biomarkers & prevention, 1997-11, Vol.6 (11), p.943 |
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| container_title | Cancer epidemiology, biomarkers & prevention |
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| creator | Stierum, R H Hageman, G J van Herwijnen, M H van der Veer, M S Kleinjans, J C |
| description | Chemical or physical modification of DNA may cause an increase in genomic mutations or other genetic alterations, which may
ultimately result in the onset of cancer. To avoid these deleterious effects of DNA damage, humans possess DNA repair mechanisms.
Decreased DNA repair, induced ex vivo by UV light or ionizing radiation in human peripheral blood lymphocytes (PBLs), has
been associated with aging. The aim of this study was to investigate whether repair of DNA damage, after ex vivo exposure
of PBLs obtained from smokers (n = 20) to (+/-)-anti-benzo(a)pyrene diolepoxide [(+/-)-anti-BPDE], which is a mixture of reactive
metabolites from the environmental carcinogen benzo(a)pyrene, is also associated with age. Furthermore, age-related associations
between ex vivo (+/-)-anti-BPDE-induced DNA repair and the frequency of endogenous cytogenetic damage (sister chromatid exchange
frequencies and micronuclei frequencies) in PBLs were evaluated. A statistically significant negative association was observed
between ex vivo (+/-)-anti-BPDE-induced unscheduled DNA synthesis and age of the donors. Also, parameters of endogenous lymphocytic
cytogenetic damage were negatively associated with ex vivo (+/-)-anti-BPDE-induced unscheduled DNA synthesis and positively
associated with age in this population. It is concluded that, with increasing age, a decrease in lymphocytic excision repair
capacity may be responsible for increased lymphocytic DNA damage in smokers. |
| format | Article |
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ultimately result in the onset of cancer. To avoid these deleterious effects of DNA damage, humans possess DNA repair mechanisms.
Decreased DNA repair, induced ex vivo by UV light or ionizing radiation in human peripheral blood lymphocytes (PBLs), has
been associated with aging. The aim of this study was to investigate whether repair of DNA damage, after ex vivo exposure
of PBLs obtained from smokers (n = 20) to (+/-)-anti-benzo(a)pyrene diolepoxide [(+/-)-anti-BPDE], which is a mixture of reactive
metabolites from the environmental carcinogen benzo(a)pyrene, is also associated with age. Furthermore, age-related associations
between ex vivo (+/-)-anti-BPDE-induced DNA repair and the frequency of endogenous cytogenetic damage (sister chromatid exchange
frequencies and micronuclei frequencies) in PBLs were evaluated. A statistically significant negative association was observed
between ex vivo (+/-)-anti-BPDE-induced unscheduled DNA synthesis and age of the donors. Also, parameters of endogenous lymphocytic
cytogenetic damage were negatively associated with ex vivo (+/-)-anti-BPDE-induced unscheduled DNA synthesis and positively
associated with age in this population. It is concluded that, with increasing age, a decrease in lymphocytic excision repair
capacity may be responsible for increased lymphocytic DNA damage in smokers.</description><identifier>ISSN: 1055-9965</identifier><identifier>EISSN: 1538-7755</identifier><identifier>PMID: 9367068</identifier><language>eng</language><publisher>United States: American Association for Cancer Research</publisher><subject>Adult ; Aging - genetics ; Benzopyrenes - adverse effects ; Benzopyrenes - pharmacology ; Carcinogens, Environmental - adverse effects ; Carcinogens, Environmental - pharmacology ; DNA Damage - genetics ; DNA Repair - drug effects ; Humans ; Lymphocytes - drug effects ; Lymphocytes - ultrastructure ; Male ; Micronuclei, Chromosome-Defective - drug effects ; Micronuclei, Chromosome-Defective - genetics ; Middle Aged ; Sister Chromatid Exchange - genetics ; Smoking - adverse effects ; Tobacco Smoke Pollution - adverse effects</subject><ispartof>Cancer epidemiology, biomarkers & prevention, 1997-11, Vol.6 (11), p.943</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9367068$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Stierum, R H</creatorcontrib><creatorcontrib>Hageman, G J</creatorcontrib><creatorcontrib>van Herwijnen, M H</creatorcontrib><creatorcontrib>van der Veer, M S</creatorcontrib><creatorcontrib>Kleinjans, J C</creatorcontrib><title>Age-related negative associations between parameters of cytogenetic damage and ex vivo (+/-)-anti-benzo(a)pyrene diolepoxide-induced unscheduled DNA synthesis in smoking humans</title><title>Cancer epidemiology, biomarkers & prevention</title><addtitle>Cancer Epidemiol Biomarkers Prev</addtitle><description>Chemical or physical modification of DNA may cause an increase in genomic mutations or other genetic alterations, which may
ultimately result in the onset of cancer. To avoid these deleterious effects of DNA damage, humans possess DNA repair mechanisms.
Decreased DNA repair, induced ex vivo by UV light or ionizing radiation in human peripheral blood lymphocytes (PBLs), has
been associated with aging. The aim of this study was to investigate whether repair of DNA damage, after ex vivo exposure
of PBLs obtained from smokers (n = 20) to (+/-)-anti-benzo(a)pyrene diolepoxide [(+/-)-anti-BPDE], which is a mixture of reactive
metabolites from the environmental carcinogen benzo(a)pyrene, is also associated with age. Furthermore, age-related associations
between ex vivo (+/-)-anti-BPDE-induced DNA repair and the frequency of endogenous cytogenetic damage (sister chromatid exchange
frequencies and micronuclei frequencies) in PBLs were evaluated. A statistically significant negative association was observed
between ex vivo (+/-)-anti-BPDE-induced unscheduled DNA synthesis and age of the donors. Also, parameters of endogenous lymphocytic
cytogenetic damage were negatively associated with ex vivo (+/-)-anti-BPDE-induced unscheduled DNA synthesis and positively
associated with age in this population. It is concluded that, with increasing age, a decrease in lymphocytic excision repair
capacity may be responsible for increased lymphocytic DNA damage in smokers.</description><subject>Adult</subject><subject>Aging - genetics</subject><subject>Benzopyrenes - adverse effects</subject><subject>Benzopyrenes - pharmacology</subject><subject>Carcinogens, Environmental - adverse effects</subject><subject>Carcinogens, Environmental - pharmacology</subject><subject>DNA Damage - genetics</subject><subject>DNA Repair - drug effects</subject><subject>Humans</subject><subject>Lymphocytes - drug effects</subject><subject>Lymphocytes - ultrastructure</subject><subject>Male</subject><subject>Micronuclei, Chromosome-Defective - drug effects</subject><subject>Micronuclei, Chromosome-Defective - genetics</subject><subject>Middle Aged</subject><subject>Sister Chromatid Exchange - genetics</subject><subject>Smoking - adverse effects</subject><subject>Tobacco Smoke Pollution - adverse effects</subject><issn>1055-9965</issn><issn>1538-7755</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNotkMtOwzAQRSMEKqXwCUje0QpZxEmdx7IqT6mCDayjiT1JDI0d2U7b8FV8IpHa1Rzp3DsjzVkwZTzOaJpyfj5yyDnN84RfBlfOfYdhmOacT4JJHidpmGTT4G9VI7W4BY-SaKzBqx0ScM4INbLRjpTo94iadGChRY_WEVMRMXhTo0avBJHQQj22tCR4IDu1M2R-_0AXFLRXtET9a-aw6AY75olUZoudOSiJVGnZi_Fwr51oUPbbkR_fV8QN2jfolCNKE9eaH6Vr0vQtaHcdXFSwdXhzmrPg6_npc_1KNx8vb-vVhjZRnHmKHLBieZxVEIk45SnLqxKyTLAMkmSZQAWMAxNQ5ZJlWIYgojCN-FKWUC4himfB7XFv15ctyqKzqgU7FKfPjf7u6BtVN3tlsRCgBVqLDsGKpkgKxop8Gcf_A5t91w</recordid><startdate>19971101</startdate><enddate>19971101</enddate><creator>Stierum, R H</creator><creator>Hageman, G J</creator><creator>van Herwijnen, M H</creator><creator>van der Veer, M S</creator><creator>Kleinjans, J C</creator><general>American Association for Cancer Research</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>19971101</creationdate><title>Age-related negative associations between parameters of cytogenetic damage and ex vivo (+/-)-anti-benzo(a)pyrene diolepoxide-induced unscheduled DNA synthesis in smoking humans</title><author>Stierum, R H ; Hageman, G J ; van Herwijnen, M H ; van der Veer, M S ; Kleinjans, J C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h238t-e5aef1938fa2c375719fba88c18a6646afa15a1caf9d18eb0ac207254dbab4a23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Adult</topic><topic>Aging - genetics</topic><topic>Benzopyrenes - adverse effects</topic><topic>Benzopyrenes - pharmacology</topic><topic>Carcinogens, Environmental - adverse effects</topic><topic>Carcinogens, Environmental - pharmacology</topic><topic>DNA Damage - genetics</topic><topic>DNA Repair - drug effects</topic><topic>Humans</topic><topic>Lymphocytes - drug effects</topic><topic>Lymphocytes - ultrastructure</topic><topic>Male</topic><topic>Micronuclei, Chromosome-Defective - drug effects</topic><topic>Micronuclei, Chromosome-Defective - genetics</topic><topic>Middle Aged</topic><topic>Sister Chromatid Exchange - genetics</topic><topic>Smoking - adverse effects</topic><topic>Tobacco Smoke Pollution - adverse effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Stierum, R H</creatorcontrib><creatorcontrib>Hageman, G J</creatorcontrib><creatorcontrib>van Herwijnen, M H</creatorcontrib><creatorcontrib>van der Veer, M S</creatorcontrib><creatorcontrib>Kleinjans, J C</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Cancer epidemiology, biomarkers & prevention</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Stierum, R H</au><au>Hageman, G J</au><au>van Herwijnen, M H</au><au>van der Veer, M S</au><au>Kleinjans, J C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Age-related negative associations between parameters of cytogenetic damage and ex vivo (+/-)-anti-benzo(a)pyrene diolepoxide-induced unscheduled DNA synthesis in smoking humans</atitle><jtitle>Cancer epidemiology, biomarkers & prevention</jtitle><addtitle>Cancer Epidemiol Biomarkers Prev</addtitle><date>1997-11-01</date><risdate>1997</risdate><volume>6</volume><issue>11</issue><spage>943</spage><pages>943-</pages><issn>1055-9965</issn><eissn>1538-7755</eissn><abstract>Chemical or physical modification of DNA may cause an increase in genomic mutations or other genetic alterations, which may
ultimately result in the onset of cancer. To avoid these deleterious effects of DNA damage, humans possess DNA repair mechanisms.
Decreased DNA repair, induced ex vivo by UV light or ionizing radiation in human peripheral blood lymphocytes (PBLs), has
been associated with aging. The aim of this study was to investigate whether repair of DNA damage, after ex vivo exposure
of PBLs obtained from smokers (n = 20) to (+/-)-anti-benzo(a)pyrene diolepoxide [(+/-)-anti-BPDE], which is a mixture of reactive
metabolites from the environmental carcinogen benzo(a)pyrene, is also associated with age. Furthermore, age-related associations
between ex vivo (+/-)-anti-BPDE-induced DNA repair and the frequency of endogenous cytogenetic damage (sister chromatid exchange
frequencies and micronuclei frequencies) in PBLs were evaluated. A statistically significant negative association was observed
between ex vivo (+/-)-anti-BPDE-induced unscheduled DNA synthesis and age of the donors. Also, parameters of endogenous lymphocytic
cytogenetic damage were negatively associated with ex vivo (+/-)-anti-BPDE-induced unscheduled DNA synthesis and positively
associated with age in this population. It is concluded that, with increasing age, a decrease in lymphocytic excision repair
capacity may be responsible for increased lymphocytic DNA damage in smokers.</abstract><cop>United States</cop><pub>American Association for Cancer Research</pub><pmid>9367068</pmid></addata></record> |
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| ispartof | Cancer epidemiology, biomarkers & prevention, 1997-11, Vol.6 (11), p.943 |
| issn | 1055-9965 1538-7755 |
| language | eng |
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| source | MEDLINE; American Association for Cancer Research; EZB-FREE-00999 freely available EZB journals |
| subjects | Adult Aging - genetics Benzopyrenes - adverse effects Benzopyrenes - pharmacology Carcinogens, Environmental - adverse effects Carcinogens, Environmental - pharmacology DNA Damage - genetics DNA Repair - drug effects Humans Lymphocytes - drug effects Lymphocytes - ultrastructure Male Micronuclei, Chromosome-Defective - drug effects Micronuclei, Chromosome-Defective - genetics Middle Aged Sister Chromatid Exchange - genetics Smoking - adverse effects Tobacco Smoke Pollution - adverse effects |
| title | Age-related negative associations between parameters of cytogenetic damage and ex vivo (+/-)-anti-benzo(a)pyrene diolepoxide-induced unscheduled DNA synthesis in smoking humans |
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