Modulation of the effect of bilirubin on protein phosphorylation by lysine-containing peptides

Protein phosphorylation is an important mechanism for regulation of cell processes. Bilirubin inhibits phosphorylation of several peptides/proteins by a number of different kinases, and this may contribute to the toxic effects of bilirubin on cells, particularly neurons. Bilirubin binds to lysine re...

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Veröffentlicht in:	Pediatric research 1997-11, Vol.42 (5), p.615-617
Hauptverfasser:	HANSEN, T. W. R, MATHIESEN, S. B. W, WALAAS, S. I
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Bilirubin - physiology Biological and medical sciences Catalysis Cyclic AMP-Dependent Protein Kinases - metabolism Emergency and intensive care: neonates and children. Prematurity. Sudden death Intensive care medicine Lysine - analysis Medical sciences Molecular Sequence Data Peptides - chemistry Peptides - metabolism Phosphorylation Polylysine - pharmacology Proteins - metabolism
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