Control of Alternative Pre-mRNA Splicing by Distributed Pentameric Repeats

Multiple copies of the hexamer TGCATG have been shown to regulate fibronectin pre-mRNA alternative splicing. GCATG repeats also are clustered near the regulated calcitonin-specific 3′splice site in the rat calcitonin/CGRP gene. Specific mutagenesis of these repeats in calcitonin/CGRP pre-mRNA result...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1997-11, Vol.94 (23), p.12343-12347
Hauptverfasser:	Hedjran, Farah, Yeakley, Joanne M., Huh, Gene S., Hynes, Richard O., Rosenfeld, Michael G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative Splicing Animals Biochemistry Biological Sciences Calcitonin - biosynthesis Calcitonin - genetics Cell lines Cells Exons Gene expression regulation Genes Genetic mutation HeLa Cells Humans Introns Mutation Nucleotides Rats Repetitive Sequences, Nucleic Acid - genetics Ribonucleic acid RNA RNA Precursors - genetics Rodents Splicing
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