Selective tumor apoptosis by MF13, L-prolyl-L-m-[bis(chloroethyl)amino]-phenylalanyl-L-norvaline ethyl ester, a new sarcolysin containing tripeptide

ID50 and ID90 values for L-prolyl-L-m-[bis(chloroethyl)amino]-phenylalanyl-L-norvaline ethyl ester HCl (MF13), were determined in four murine (leukemia, lymphoma, melanoma, and lung) and eight human cancer cell lines (two leukemia, prostate, kidney, colon, two melanoma, and breast). Cytotoxic activi...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1997-11, Vol.57 (21), p.4795-4802
Hauptverfasser:	ROBOZ, J, JIANG, J, HOLLAND, J. F, BEKESI, J. G
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Antineoplastic Agents, Alkylating - therapeutic use Apoptosis - drug effects Apoptosis - genetics Biological and medical sciences Cell Survival Chemotherapy DNA Fragmentation DNA, Neoplasm - drug effects Drug Resistance, Neoplasm Drug Screening Assays, Antitumor Flow Cytometry Humans Lethal Dose 50 Leukemia - drug therapy Leukemia - pathology Leukemia L1210 - drug therapy Leukemia L1210 - pathology Lymphoma - drug therapy Lymphoma - pathology Medical sciences Melphalan - pharmacology Methotrexate - pharmacology Mice Neoplasms - drug therapy Neoplasms - pathology Oligopeptides - therapeutic use Pharmacology. Drug treatments Tumor Cells, Cultured - drug effects Tumor Cells, Cultured - pathology
Online-Zugang:	Volltext
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