Down-regulation of Gal alpha(1,3)Gal expression by alpha1,2-fucosyltransferase: further characterization of alpha1,2-fucosyltransferase transgenic mice

In pig-to-primate transplantation, antibody-mediated hyperacute rejection is the consequence of binding of natural antibodies to Gal alpha(1,3)Gal on pig endothelium. The elimination of the Gal alpha(1,3)Gal antigen from pig cells should prevent hyperacute rejection. Using in vitro techniques, we ha...

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Veröffentlicht in:	Transplantation 1997-08, Vol.64 (3), p.495
Hauptverfasser:	Cohney, S, McKenzie, I F, Patton, K, Prenzoska, J, Ostenreid, K, Fodor, W L, Sandrin, M S
Format:	Artikel
Sprache:	eng
Schlagworte:	ABO Blood-Group System Animals Disaccharides - genetics Down-Regulation - drug effects Female Fucosyltransferases - chemistry Fucosyltransferases - pharmacology Galactoside 2-alpha-L-fucosyltransferase Gene Expression - drug effects Gene Expression - physiology Hemagglutinins - metabolism Humans Lectins - pharmacology Mice Mice, Inbred C57BL Mice, Transgenic - genetics Plant Lectins
Online-Zugang:	Volltext
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