Prostaglandin E2 amplifies cytosolic phospholipase A2- and cyclooxygenase-2-dependent delayed prostaglandin E2 generation in mouse osteoblastic cells. Enhancement by secretory phospholipase A2

We used the MC3T3-E1 cell line, which originates from C57BL/6J mouse that is genetically type IIA secretory phospholipase A2 (sPLA2)-deficient, to reveal the type IIA sPLA2-independent route of the prostanglandin (PG) biosynthetic pathway. Kinetic and pharmacological studies showed that delayed PGE2...

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Veröffentlicht in:	The Journal of biological chemistry 1997-08, Vol.272 (32), p.19891
Hauptverfasser:	Murakami, M, Kuwata, H, Amakasu, Y, Shimbara, S, Nakatani, Y, Atsumi, G, Kudo, I
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line Cyclooxygenase 1 Cyclooxygenase 2 Cytosol - drug effects Cytosol - enzymology Dinoprostone - metabolism Dose-Response Relationship, Drug Enzyme Inhibitors - pharmacology Interleukin-1 - pharmacology Isoenzymes - metabolism Membrane Proteins Mice Mice, Inbred C57BL Osteoblasts - drug effects Osteoblasts - metabolism Peroxidases - metabolism Phospholipases A - metabolism Phospholipases A2 Prostaglandin-Endoperoxide Synthases - metabolism Tumor Necrosis Factor-alpha - pharmacology
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