Block-copolymer of Polyethylene Glycol and Polylysine as a Carrier of Organic Iodine: Design of Long-circulating Particulate Contrast Medium for X-ray Computed Tomography

Abstract In order to obtain small, polymer-stabilized particulate carriers for organic iodine to serve as a contrast agent for X-ray computed tomography (CT) an attempt was made to design a carrier based on polymeric micelles. Here we describe the synthesis of an iodine-containing amphiphilic block-...

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Veröffentlicht in:	Journal of drug targeting 1997-01, Vol.4 (6), p.381-388
Hauptverfasser:	Trubetskoy, Vladimir S., Gazelle, G. Scott, Wolf, Gerald L., Torchilin, Vladimir P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Chromatography, High Pressure Liquid contrast media Contrast Media - chemical synthesis Contrast media. Radiopharmaceuticals CT imaging Drug Carriers Drug Design General pharmacology Iodine - administration & dosage Medical sciences Particulates Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Polyethylene Glycols - chemical synthesis Polyethylene Glycols - chemistry Polylysine - analogs & derivatives Polylysine - chemical synthesis Polylysine - chemistry polymeric micelles Polymers - chemical synthesis Tomography, X-Ray Computed Triiodobenzoic Acids - chemical synthesis Triiodobenzoic Acids - chemistry
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