Endocarditis due to Pseudomonas aeruginosa in a heroin addict. Successful treatment with trimethoprim-Sulfamethoxazole mixture plus colistin
Endocarditis of the tricuspid valve due to Pseudomonas aeruginosa in a heroin addict failed to respond to therapy with gentamicin, carbenicillin, and amikacin. Clinical and bacteriologic cure was achieved with oral administration of a trimethoprim-sulfamethoxazole mixture plus parenteral therapy wit...
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| Veröffentlicht in: | Chest 1977-12, Vol.72 (6), p.794 |
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| container_title | Chest |
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| creator | Yoshikawa, T T Bayer, A S Guze, L B |
| description | Endocarditis of the tricuspid valve due to Pseudomonas aeruginosa in a heroin addict failed to respond to therapy with gentamicin,
carbenicillin, and amikacin. Clinical and bacteriologic cure was achieved with oral administration of a trimethoprim-sulfamethoxazole
mixture plus parenteral therapy with colistin. In vitro synergism was demonstrated for the three drugs at concentrations achievable
in the serum. Therapy for endocarditis due to Pseudomonas continues to be a major problem; however, the successful treatment
of this patient warrants consideration for instituting therapy with a trimethoprim-sulfamethoxazole misture plus colistin
in individuals with this infection who fail to respond to standard therapeutic regimens for severe infections with Pseudomonas. |
| doi_str_mv | 10.1378/chest.72.6.794 |
| format | Article |
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carbenicillin, and amikacin. Clinical and bacteriologic cure was achieved with oral administration of a trimethoprim-sulfamethoxazole
mixture plus parenteral therapy with colistin. In vitro synergism was demonstrated for the three drugs at concentrations achievable
in the serum. Therapy for endocarditis due to Pseudomonas continues to be a major problem; however, the successful treatment
of this patient warrants consideration for instituting therapy with a trimethoprim-sulfamethoxazole misture plus colistin
in individuals with this infection who fail to respond to standard therapeutic regimens for severe infections with Pseudomonas.</description><identifier>ISSN: 0012-3692</identifier><identifier>EISSN: 1931-3543</identifier><identifier>DOI: 10.1378/chest.72.6.794</identifier><identifier>PMID: 923322</identifier><language>eng</language><publisher>United States: American College of Chest Physicians</publisher><subject>Adult ; Colistin - therapeutic use ; Drug Combinations ; Endocarditis, Bacterial - drug therapy ; Endocarditis, Bacterial - etiology ; Heart Valve Diseases - drug therapy ; Heart Valve Diseases - etiology ; Heroin Dependence - complications ; Humans ; Male ; Pseudomonas Infections - drug therapy ; Pseudomonas Infections - etiology ; Sulfamethoxazole - therapeutic use ; Tricuspid Valve ; Trimethoprim - therapeutic use</subject><ispartof>Chest, 1977-12, Vol.72 (6), p.794</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/923322$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yoshikawa, T T</creatorcontrib><creatorcontrib>Bayer, A S</creatorcontrib><creatorcontrib>Guze, L B</creatorcontrib><title>Endocarditis due to Pseudomonas aeruginosa in a heroin addict. Successful treatment with trimethoprim-Sulfamethoxazole mixture plus colistin</title><title>Chest</title><addtitle>Chest</addtitle><description>Endocarditis of the tricuspid valve due to Pseudomonas aeruginosa in a heroin addict failed to respond to therapy with gentamicin,
carbenicillin, and amikacin. Clinical and bacteriologic cure was achieved with oral administration of a trimethoprim-sulfamethoxazole
mixture plus parenteral therapy with colistin. In vitro synergism was demonstrated for the three drugs at concentrations achievable
in the serum. Therapy for endocarditis due to Pseudomonas continues to be a major problem; however, the successful treatment
of this patient warrants consideration for instituting therapy with a trimethoprim-sulfamethoxazole misture plus colistin
in individuals with this infection who fail to respond to standard therapeutic regimens for severe infections with Pseudomonas.</description><subject>Adult</subject><subject>Colistin - therapeutic use</subject><subject>Drug Combinations</subject><subject>Endocarditis, Bacterial - drug therapy</subject><subject>Endocarditis, Bacterial - etiology</subject><subject>Heart Valve Diseases - drug therapy</subject><subject>Heart Valve Diseases - etiology</subject><subject>Heroin Dependence - complications</subject><subject>Humans</subject><subject>Male</subject><subject>Pseudomonas Infections - drug therapy</subject><subject>Pseudomonas Infections - etiology</subject><subject>Sulfamethoxazole - therapeutic use</subject><subject>Tricuspid Valve</subject><subject>Trimethoprim - therapeutic use</subject><issn>0012-3692</issn><issn>1931-3543</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1977</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNotkMtOwzAQRS3EqxS2rFj4BxL8atwsEeIlIYEErKOpPWmMnLiKbfH4Bj6alLK6c3VHo7mHkHPOSi718tJ0GFOpRVmVulZ7ZMZryQu5UHKfzBjjopBVLY7JSYzvbPK8ro7IYS2kFGJGfm4GGwyM1iUXqc1IU6DPEbMNfRggUsAxr90QIlA3UKAdjmE7WOtMKulLNgZjbLOnaURIPQ6JfrjUTdb1mLqwmbR4yb6FP_sJ38Ej7d1nyiPSjc-RmuBdTG44JQct-Ihn_zonb7c3r9f3xePT3cP11WPRCaVS0eqF5dUCFpwbVa-MBlMxwSqmRG2nYkqg5kvEVbVUS43arjhwbFXLAKQ1TM7Jxe7uJq96tM32RRi_mh2UKS53cefW3YcbsYk9eD8ty-aP9nvI4wBei6ZqJubyF-epeWE</recordid><startdate>197712</startdate><enddate>197712</enddate><creator>Yoshikawa, T T</creator><creator>Bayer, A S</creator><creator>Guze, L B</creator><general>American College of Chest Physicians</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>197712</creationdate><title>Endocarditis due to Pseudomonas aeruginosa in a heroin addict. Successful treatment with trimethoprim-Sulfamethoxazole mixture plus colistin</title><author>Yoshikawa, T T ; Bayer, A S ; Guze, L B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h244t-f75d165a511c49bc7ac602060429d92342e718eeb68487e7db1a1ef4f0aa3dc03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1977</creationdate><topic>Adult</topic><topic>Colistin - therapeutic use</topic><topic>Drug Combinations</topic><topic>Endocarditis, Bacterial - drug therapy</topic><topic>Endocarditis, Bacterial - etiology</topic><topic>Heart Valve Diseases - drug therapy</topic><topic>Heart Valve Diseases - etiology</topic><topic>Heroin Dependence - complications</topic><topic>Humans</topic><topic>Male</topic><topic>Pseudomonas Infections - drug therapy</topic><topic>Pseudomonas Infections - etiology</topic><topic>Sulfamethoxazole - therapeutic use</topic><topic>Tricuspid Valve</topic><topic>Trimethoprim - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yoshikawa, T T</creatorcontrib><creatorcontrib>Bayer, A S</creatorcontrib><creatorcontrib>Guze, L B</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Chest</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yoshikawa, T T</au><au>Bayer, A S</au><au>Guze, L B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Endocarditis due to Pseudomonas aeruginosa in a heroin addict. Successful treatment with trimethoprim-Sulfamethoxazole mixture plus colistin</atitle><jtitle>Chest</jtitle><addtitle>Chest</addtitle><date>1977-12</date><risdate>1977</risdate><volume>72</volume><issue>6</issue><spage>794</spage><pages>794-</pages><issn>0012-3692</issn><eissn>1931-3543</eissn><abstract>Endocarditis of the tricuspid valve due to Pseudomonas aeruginosa in a heroin addict failed to respond to therapy with gentamicin,
carbenicillin, and amikacin. Clinical and bacteriologic cure was achieved with oral administration of a trimethoprim-sulfamethoxazole
mixture plus parenteral therapy with colistin. In vitro synergism was demonstrated for the three drugs at concentrations achievable
in the serum. Therapy for endocarditis due to Pseudomonas continues to be a major problem; however, the successful treatment
of this patient warrants consideration for instituting therapy with a trimethoprim-sulfamethoxazole misture plus colistin
in individuals with this infection who fail to respond to standard therapeutic regimens for severe infections with Pseudomonas.</abstract><cop>United States</cop><pub>American College of Chest Physicians</pub><pmid>923322</pmid><doi>10.1378/chest.72.6.794</doi></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0012-3692 |
| ispartof | Chest, 1977-12, Vol.72 (6), p.794 |
| issn | 0012-3692 1931-3543 |
| language | eng |
| recordid | cdi_pubmed_primary_923322 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Adult Colistin - therapeutic use Drug Combinations Endocarditis, Bacterial - drug therapy Endocarditis, Bacterial - etiology Heart Valve Diseases - drug therapy Heart Valve Diseases - etiology Heroin Dependence - complications Humans Male Pseudomonas Infections - drug therapy Pseudomonas Infections - etiology Sulfamethoxazole - therapeutic use Tricuspid Valve Trimethoprim - therapeutic use |
| title | Endocarditis due to Pseudomonas aeruginosa in a heroin addict. Successful treatment with trimethoprim-Sulfamethoxazole mixture plus colistin |
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