Allosteric Intermediates Indicate R2 is the Liganded Hemoglobin end State

Hemoglobin has been a long-standing paradigm for understanding protein allostery. Here, the x-ray structures of two chemically crosslinked, fully liganded hemoglobins, α2β82CA82β and α2β82ND82β , are described at 2.3 angstrom and 2.6 angstrom resolution, respectively. Strikingly, these crosslinked h...

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