Correlation of ribonucleic acid polymerase chain reaction, acid dissociated p24 antigen, and neopterin with progression of disease a retrospective, longitudinal study of vertically acquired human immunodeficiency virus type 1 infection in children
We investigated the relationship between cell-free viral load, neopterin, age-adjusted CD4+ cell concentration, and clinical events in 49 children with vertically acquired human immunodeficiency virus type 1 infection. Viral load was measured by quantitating viral ribonucleic acid in serum by polyme...
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| Veröffentlicht in: | The Journal of pediatrics 1997-06, Vol.130 (6), p.898-905 |
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| container_title | The Journal of pediatrics |
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| creator | ZAKNUN, D ORAV, J KORNEGAY, J AL-ATTAR, I FUCHS, D ZAKNUN, J WACHTER, H CHATIS, P BURCHETT, S. K MCINTOSH, K |
| description | We investigated the relationship between cell-free viral load, neopterin, age-adjusted CD4+ cell concentration, and clinical events in 49 children with vertically acquired human immunodeficiency virus type 1 infection.
Viral load was measured by quantitating viral ribonucleic acid in serum by polymerase chain reaction and measurement of immune complex dissociated p24 antigen in serum and plasma. Children were followed for an average of 2 1/2 years, with an average of 6 samples per child. Medical records were reviewed for weight, CD4+ cell count and clinical events.
High virus copy number in serum was predictive of a decrease in weight-for-age zscore during the subsequent 6 months. High viral load, low CD4+ cell count, and high neopterin level were correlated with encephalopathy. High viral load correlated with opportunistic infections. All of these relationships held regardless of treatment status, although viral load decreased significantly after treatment was begun.
Measurements of viral load were useful prognostic indicators for poor weight gain. Elevated serum virus levels and neopterin values and low CD4+ cell counts were all associated with encephalopathy. |
| doi_str_mv | 10.1016/S0022-3476(97)70275-0 |
| format | Article |
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Viral load was measured by quantitating viral ribonucleic acid in serum by polymerase chain reaction and measurement of immune complex dissociated p24 antigen in serum and plasma. Children were followed for an average of 2 1/2 years, with an average of 6 samples per child. Medical records were reviewed for weight, CD4+ cell count and clinical events.
High virus copy number in serum was predictive of a decrease in weight-for-age zscore during the subsequent 6 months. High viral load, low CD4+ cell count, and high neopterin level were correlated with encephalopathy. High viral load correlated with opportunistic infections. All of these relationships held regardless of treatment status, although viral load decreased significantly after treatment was begun.
Measurements of viral load were useful prognostic indicators for poor weight gain. Elevated serum virus levels and neopterin values and low CD4+ cell counts were all associated with encephalopathy.</description><identifier>ISSN: 0022-3476</identifier><identifier>EISSN: 1097-6833</identifier><identifier>DOI: 10.1016/S0022-3476(97)70275-0</identifier><identifier>PMID: 9202611</identifier><identifier>CODEN: JOPDAB</identifier><language>eng</language><publisher>New York, NY: Elsevier</publisher><subject>Acquired Immunodeficiency Syndrome - drug therapy ; Acquired Immunodeficiency Syndrome - virology ; Anti-HIV Agents - therapeutic use ; Biological and medical sciences ; Biopterins - analogs & derivatives ; Biopterins - blood ; CD4 Lymphocyte Count ; Child ; Child, Preschool ; Female ; HIV Core Protein p24 ; HIV-1 ; Humans ; Immunodeficiencies ; Immunodeficiencies. Immunoglobulinopathies ; Immunopathology ; Infant ; Longitudinal Studies ; Male ; Medical sciences ; Neopterin ; Polymerase Chain Reaction ; Retrospective Studies ; RNA, Viral ; Viral Load ; Zalcitabine - therapeutic use ; Zidovudine - therapeutic use</subject><ispartof>The Journal of pediatrics, 1997-06, Vol.130 (6), p.898-905</ispartof><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2713653$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9202611$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ZAKNUN, D</creatorcontrib><creatorcontrib>ORAV, J</creatorcontrib><creatorcontrib>KORNEGAY, J</creatorcontrib><creatorcontrib>AL-ATTAR, I</creatorcontrib><creatorcontrib>FUCHS, D</creatorcontrib><creatorcontrib>ZAKNUN, J</creatorcontrib><creatorcontrib>WACHTER, H</creatorcontrib><creatorcontrib>CHATIS, P</creatorcontrib><creatorcontrib>BURCHETT, S. K</creatorcontrib><creatorcontrib>MCINTOSH, K</creatorcontrib><title>Correlation of ribonucleic acid polymerase chain reaction, acid dissociated p24 antigen, and neopterin with progression of disease a retrospective, longitudinal study of vertically acquired human immunodeficiency virus type 1 infection in children</title><title>The Journal of pediatrics</title><addtitle>J Pediatr</addtitle><description>We investigated the relationship between cell-free viral load, neopterin, age-adjusted CD4+ cell concentration, and clinical events in 49 children with vertically acquired human immunodeficiency virus type 1 infection.
Viral load was measured by quantitating viral ribonucleic acid in serum by polymerase chain reaction and measurement of immune complex dissociated p24 antigen in serum and plasma. Children were followed for an average of 2 1/2 years, with an average of 6 samples per child. Medical records were reviewed for weight, CD4+ cell count and clinical events.
High virus copy number in serum was predictive of a decrease in weight-for-age zscore during the subsequent 6 months. High viral load, low CD4+ cell count, and high neopterin level were correlated with encephalopathy. High viral load correlated with opportunistic infections. All of these relationships held regardless of treatment status, although viral load decreased significantly after treatment was begun.
Measurements of viral load were useful prognostic indicators for poor weight gain. Elevated serum virus levels and neopterin values and low CD4+ cell counts were all associated with encephalopathy.</description><subject>Acquired Immunodeficiency Syndrome - drug therapy</subject><subject>Acquired Immunodeficiency Syndrome - virology</subject><subject>Anti-HIV Agents - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Biopterins - analogs & derivatives</subject><subject>Biopterins - blood</subject><subject>CD4 Lymphocyte Count</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Female</subject><subject>HIV Core Protein p24</subject><subject>HIV-1</subject><subject>Humans</subject><subject>Immunodeficiencies</subject><subject>Immunodeficiencies. Immunoglobulinopathies</subject><subject>Immunopathology</subject><subject>Infant</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neopterin</subject><subject>Polymerase Chain Reaction</subject><subject>Retrospective Studies</subject><subject>RNA, Viral</subject><subject>Viral Load</subject><subject>Zalcitabine - therapeutic use</subject><subject>Zidovudine - therapeutic use</subject><issn>0022-3476</issn><issn>1097-6833</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kU2LFDEQhoMo67j6ExZy8KCwrfnoSdJHGfyCBQ_qealJV8-UdCdtkh7pX-7VjDvsqQqet963imLsRop3Ukjz_rsQSjW6teZNZ99aoey2EU_YRorONsZp_ZRtHiXP2YucfwkhulaIK3bVKaGMlBv2dxdTwhEKxcDjwBPtY1j8iOQ5eOr5HMd1wgQZuT8CBZ4Q_Fl9-8B7yjl6goJVq1oOodABzzT0PGCcC6Y69YfKkc8pHhLmfMmqo3j2hepZUswzVuMT3vIxhgOVpacAI8-1Wc_yE6ZCHsZxrcm_F0o18bhMEDhN0xJijwN5wuBXfqK0ZF7WGbnkFAb8v3Ht6g009gnDS_ZsgDHjq0u9Zj8_ffyx-9Lcffv8dffhrpmV3pYGRYt-a5xwUu21c3bopLPgJEhtQJtBd861quu20rpBSAUdisHsjdHW9xVfs5sH33nZT9jfz4kmSOv95QGVv75wyPW2IUHwlB9lytacrdb_ALgnnEI</recordid><startdate>19970601</startdate><enddate>19970601</enddate><creator>ZAKNUN, D</creator><creator>ORAV, J</creator><creator>KORNEGAY, J</creator><creator>AL-ATTAR, I</creator><creator>FUCHS, D</creator><creator>ZAKNUN, J</creator><creator>WACHTER, H</creator><creator>CHATIS, P</creator><creator>BURCHETT, S. K</creator><creator>MCINTOSH, K</creator><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>19970601</creationdate><title>Correlation of ribonucleic acid polymerase chain reaction, acid dissociated p24 antigen, and neopterin with progression of disease a retrospective, longitudinal study of vertically acquired human immunodeficiency virus type 1 infection in children</title><author>ZAKNUN, D ; ORAV, J ; KORNEGAY, J ; AL-ATTAR, I ; FUCHS, D ; ZAKNUN, J ; WACHTER, H ; CHATIS, P ; BURCHETT, S. K ; MCINTOSH, K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p235t-e04ec5680812b3887f9187a81a136a36f398842995178f012a9e0f6b6637cd6f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Acquired Immunodeficiency Syndrome - drug therapy</topic><topic>Acquired Immunodeficiency Syndrome - virology</topic><topic>Anti-HIV Agents - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Biopterins - analogs & derivatives</topic><topic>Biopterins - blood</topic><topic>CD4 Lymphocyte Count</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Female</topic><topic>HIV Core Protein p24</topic><topic>HIV-1</topic><topic>Humans</topic><topic>Immunodeficiencies</topic><topic>Immunodeficiencies. Immunoglobulinopathies</topic><topic>Immunopathology</topic><topic>Infant</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neopterin</topic><topic>Polymerase Chain Reaction</topic><topic>Retrospective Studies</topic><topic>RNA, Viral</topic><topic>Viral Load</topic><topic>Zalcitabine - therapeutic use</topic><topic>Zidovudine - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ZAKNUN, D</creatorcontrib><creatorcontrib>ORAV, J</creatorcontrib><creatorcontrib>KORNEGAY, J</creatorcontrib><creatorcontrib>AL-ATTAR, I</creatorcontrib><creatorcontrib>FUCHS, D</creatorcontrib><creatorcontrib>ZAKNUN, J</creatorcontrib><creatorcontrib>WACHTER, H</creatorcontrib><creatorcontrib>CHATIS, P</creatorcontrib><creatorcontrib>BURCHETT, S. K</creatorcontrib><creatorcontrib>MCINTOSH, K</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>The Journal of pediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ZAKNUN, D</au><au>ORAV, J</au><au>KORNEGAY, J</au><au>AL-ATTAR, I</au><au>FUCHS, D</au><au>ZAKNUN, J</au><au>WACHTER, H</au><au>CHATIS, P</au><au>BURCHETT, S. K</au><au>MCINTOSH, K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Correlation of ribonucleic acid polymerase chain reaction, acid dissociated p24 antigen, and neopterin with progression of disease a retrospective, longitudinal study of vertically acquired human immunodeficiency virus type 1 infection in children</atitle><jtitle>The Journal of pediatrics</jtitle><addtitle>J Pediatr</addtitle><date>1997-06-01</date><risdate>1997</risdate><volume>130</volume><issue>6</issue><spage>898</spage><epage>905</epage><pages>898-905</pages><issn>0022-3476</issn><eissn>1097-6833</eissn><coden>JOPDAB</coden><abstract>We investigated the relationship between cell-free viral load, neopterin, age-adjusted CD4+ cell concentration, and clinical events in 49 children with vertically acquired human immunodeficiency virus type 1 infection.
Viral load was measured by quantitating viral ribonucleic acid in serum by polymerase chain reaction and measurement of immune complex dissociated p24 antigen in serum and plasma. Children were followed for an average of 2 1/2 years, with an average of 6 samples per child. Medical records were reviewed for weight, CD4+ cell count and clinical events.
High virus copy number in serum was predictive of a decrease in weight-for-age zscore during the subsequent 6 months. High viral load, low CD4+ cell count, and high neopterin level were correlated with encephalopathy. High viral load correlated with opportunistic infections. All of these relationships held regardless of treatment status, although viral load decreased significantly after treatment was begun.
Measurements of viral load were useful prognostic indicators for poor weight gain. Elevated serum virus levels and neopterin values and low CD4+ cell counts were all associated with encephalopathy.</abstract><cop>New York, NY</cop><pub>Elsevier</pub><pmid>9202611</pmid><doi>10.1016/S0022-3476(97)70275-0</doi><tpages>8</tpages></addata></record> |
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| ispartof | The Journal of pediatrics, 1997-06, Vol.130 (6), p.898-905 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Acquired Immunodeficiency Syndrome - drug therapy Acquired Immunodeficiency Syndrome - virology Anti-HIV Agents - therapeutic use Biological and medical sciences Biopterins - analogs & derivatives Biopterins - blood CD4 Lymphocyte Count Child Child, Preschool Female HIV Core Protein p24 HIV-1 Humans Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Infant Longitudinal Studies Male Medical sciences Neopterin Polymerase Chain Reaction Retrospective Studies RNA, Viral Viral Load Zalcitabine - therapeutic use Zidovudine - therapeutic use |
| title | Correlation of ribonucleic acid polymerase chain reaction, acid dissociated p24 antigen, and neopterin with progression of disease a retrospective, longitudinal study of vertically acquired human immunodeficiency virus type 1 infection in children |
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