All-trans-retinoic acid mediates G1 arrest but not apoptosis of normal human mammary epithelial cells

Retinoids mediate the normal growth of a variety of epithelial cells and may play an important role in the chemoprevention of certain malignancies. Loss of retinoic acid (RA) receptor-beta function may be an important event in mammary carcinogenesis, because the majority of breast cancers, in contra...

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Veröffentlicht in:	Cell growth & differentiation 1997-06, Vol.8 (6), p.631-641
Hauptverfasser:	SEEWALDT, V. L, KIM, J.-H, CALDWELL, L. E, JOHNSON, B. S, SWISSHELM, K, COLLINS, S. J
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Biological and medical sciences Blotting, Northern Breast - cytology Breast - metabolism Breast Neoplasms - metabolism Breast Neoplasms - pathology Cell cycle, cell proliferation Cell physiology Cells, Cultured Cyclin D1 Cyclin-Dependent Kinase 4 Cyclin-Dependent Kinases - antagonists & inhibitors Cyclin-Dependent Kinases - metabolism Cyclins - antagonists & inhibitors Cyclins - metabolism DNA - analysis Epithelial Cells Epithelium - metabolism Fundamental and applied biological sciences. Psychology G1 Phase - drug effects Gene Expression Regulation - genetics Growth Inhibitors - metabolism Growth Inhibitors - pharmacology Humans Molecular and cellular biology Oncogene Proteins - antagonists & inhibitors Oncogene Proteins - metabolism Proto-Oncogene Proteins Receptors, Retinoic Acid - genetics Retinoblastoma Protein - antagonists & inhibitors Retinoblastoma Protein - metabolism RNA, Messenger - analysis Transcriptional Activation - genetics Transfection Tretinoin - metabolism Tretinoin - pharmacology
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