Histological effect of (R)-α-methylhistamine on ethanol damage in rat gastric mucosa influence on mucus production

(R)-alpha-Methylhistamine, a selective agonist of histamine H3 receptors, prevents macroscopically visible gastric lesions by absolute ethanol in the rat. A further insight into its activity was the aim of our study. Rats were given saline or (R)-alpha-methylhistamine (100 mg/kg) intragastrically. A...

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Veröffentlicht in:	Digestive diseases and sciences 1997-05, Vol.42 (5), p.1020-1028
Hauptverfasser:	MORINI, G, GRANDI, D, ARCARI, M. L, GALANTI, G, BERTACCINI, G
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Digestive system Ethanol - toxicity Gastric Mucosa - drug effects Gastric Mucosa - metabolism Gastric Mucosa - ultrastructure Histamine Agonists - pharmacology Male Medical sciences Methylhistamines - pharmacology Microscopy, Electron Microscopy, Electron, Scanning Mucus - metabolism Pharmacology. Drug treatments Rats Rats, Wistar Receptors, Histamine H3 - drug effects Receptors, Histamine H3 - physiology
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