Histological effect of (R)-α-methylhistamine on ethanol damage in rat gastric mucosa influence on mucus production
(R)-alpha-Methylhistamine, a selective agonist of histamine H3 receptors, prevents macroscopically visible gastric lesions by absolute ethanol in the rat. A further insight into its activity was the aim of our study. Rats were given saline or (R)-alpha-methylhistamine (100 mg/kg) intragastrically. A...
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| Veröffentlicht in: | Digestive diseases and sciences 1997-05, Vol.42 (5), p.1020-1028 |
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| container_title | Digestive diseases and sciences |
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| creator | MORINI, G GRANDI, D ARCARI, M. L GALANTI, G BERTACCINI, G |
| description | (R)-alpha-Methylhistamine, a selective agonist of histamine H3 receptors, prevents macroscopically visible gastric lesions by absolute ethanol in the rat. A further insight into its activity was the aim of our study. Rats were given saline or (R)-alpha-methylhistamine (100 mg/kg) intragastrically. After 30 min, absolute ethanol was given and gastric mucosa was sampled 60 min later. Histologic damage and intracellular and adherent mucus were quantified. Luminal surface and mucous cells were examined by scanning and transmission electron microscopy. (R)-alpha-Methylhistamine reduced the extent of lesions by ethanol from 96 to 18%. Surface mucous cells and mucous neck cells were increased in volume and number, packaging of intracellular mucus was modified, and the secretory processes were promoted by (R)-alpha-methylhistamine itself, although these modifications were mostly evident in stomachs subsequently exposed to ethanol. Adherent mucus layer thickness was increased by (R)-alpha-methylhistamine only after ethanol exposure. It is concluded that (R)-alpha-methylhistamine predisposes mucous cells to react to ethanol. |
| doi_str_mv | 10.1023/A:1018841204104 |
| format | Article |
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L ; GALANTI, G ; BERTACCINI, G</creator><creatorcontrib>MORINI, G ; GRANDI, D ; ARCARI, M. L ; GALANTI, G ; BERTACCINI, G</creatorcontrib><description>(R)-alpha-Methylhistamine, a selective agonist of histamine H3 receptors, prevents macroscopically visible gastric lesions by absolute ethanol in the rat. A further insight into its activity was the aim of our study. Rats were given saline or (R)-alpha-methylhistamine (100 mg/kg) intragastrically. After 30 min, absolute ethanol was given and gastric mucosa was sampled 60 min later. Histologic damage and intracellular and adherent mucus were quantified. Luminal surface and mucous cells were examined by scanning and transmission electron microscopy. (R)-alpha-Methylhistamine reduced the extent of lesions by ethanol from 96 to 18%. Surface mucous cells and mucous neck cells were increased in volume and number, packaging of intracellular mucus was modified, and the secretory processes were promoted by (R)-alpha-methylhistamine itself, although these modifications were mostly evident in stomachs subsequently exposed to ethanol. Adherent mucus layer thickness was increased by (R)-alpha-methylhistamine only after ethanol exposure. It is concluded that (R)-alpha-methylhistamine predisposes mucous cells to react to ethanol.</description><identifier>ISSN: 0163-2116</identifier><identifier>EISSN: 1573-2568</identifier><identifier>DOI: 10.1023/A:1018841204104</identifier><identifier>PMID: 9149057</identifier><identifier>CODEN: DDSCDJ</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>Animals ; Biological and medical sciences ; Digestive system ; Ethanol - toxicity ; Gastric Mucosa - drug effects ; Gastric Mucosa - metabolism ; Gastric Mucosa - ultrastructure ; Histamine Agonists - pharmacology ; Male ; Medical sciences ; Methylhistamines - pharmacology ; Microscopy, Electron ; Microscopy, Electron, Scanning ; Mucus - metabolism ; Pharmacology. Drug treatments ; Rats ; Rats, Wistar ; Receptors, Histamine H3 - drug effects ; Receptors, Histamine H3 - physiology</subject><ispartof>Digestive diseases and sciences, 1997-05, Vol.42 (5), p.1020-1028</ispartof><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c281t-c14cb86f496290c4930c711ff932284c6a4d73a5aefdd3caa1971a8f64a4b9473</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2668514$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9149057$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MORINI, G</creatorcontrib><creatorcontrib>GRANDI, D</creatorcontrib><creatorcontrib>ARCARI, M. L</creatorcontrib><creatorcontrib>GALANTI, G</creatorcontrib><creatorcontrib>BERTACCINI, G</creatorcontrib><title>Histological effect of (R)-α-methylhistamine on ethanol damage in rat gastric mucosa influence on mucus production</title><title>Digestive diseases and sciences</title><addtitle>Dig Dis Sci</addtitle><description>(R)-alpha-Methylhistamine, a selective agonist of histamine H3 receptors, prevents macroscopically visible gastric lesions by absolute ethanol in the rat. A further insight into its activity was the aim of our study. Rats were given saline or (R)-alpha-methylhistamine (100 mg/kg) intragastrically. After 30 min, absolute ethanol was given and gastric mucosa was sampled 60 min later. Histologic damage and intracellular and adherent mucus were quantified. Luminal surface and mucous cells were examined by scanning and transmission electron microscopy. (R)-alpha-Methylhistamine reduced the extent of lesions by ethanol from 96 to 18%. Surface mucous cells and mucous neck cells were increased in volume and number, packaging of intracellular mucus was modified, and the secretory processes were promoted by (R)-alpha-methylhistamine itself, although these modifications were mostly evident in stomachs subsequently exposed to ethanol. Adherent mucus layer thickness was increased by (R)-alpha-methylhistamine only after ethanol exposure. It is concluded that (R)-alpha-methylhistamine predisposes mucous cells to react to ethanol.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Digestive system</subject><subject>Ethanol - toxicity</subject><subject>Gastric Mucosa - drug effects</subject><subject>Gastric Mucosa - metabolism</subject><subject>Gastric Mucosa - ultrastructure</subject><subject>Histamine Agonists - pharmacology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Methylhistamines - pharmacology</subject><subject>Microscopy, Electron</subject><subject>Microscopy, Electron, Scanning</subject><subject>Mucus - metabolism</subject><subject>Pharmacology. Drug treatments</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Receptors, Histamine H3 - drug effects</subject><subject>Receptors, Histamine H3 - physiology</subject><issn>0163-2116</issn><issn>1573-2568</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9j8FKAzEQhoMoWqtnT0IOHvSwmkmy2cRbKWqFgiB6LtNsUiO7m7LZPfSxfBGfyaDF0wzf_8_AR8gFsFtgXNzN7oGB1hI4k8DkAZlAWYmCl0ofkgkDlXcAdUJOU_pkjJkK1DE5NiANK6sJSYuQhtjETbDYUOe9swONnl6_3hTfX0Xrho9d85E72IbO0djRTLCLDa2xxY2joaM9DnSDaeiDpe1oY8JMfTO6zv5eZDYmuu1jPdohxO6MHHlskjvfzyl5f3x4my-K5cvT83y2LCzXMBQWpF1r5aVR3DArjWC2AvDeCM61tAplXQks0fm6FhYRshxqryTKtZGVmJLLv7_bcd26erXtQ4v9brWXz_nVPseU7X2PnQ3pv8aV0iVI8QOKcWpw</recordid><startdate>19970501</startdate><enddate>19970501</enddate><creator>MORINI, G</creator><creator>GRANDI, D</creator><creator>ARCARI, M. L</creator><creator>GALANTI, G</creator><creator>BERTACCINI, G</creator><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>19970501</creationdate><title>Histological effect of (R)-α-methylhistamine on ethanol damage in rat gastric mucosa influence on mucus production</title><author>MORINI, G ; GRANDI, D ; ARCARI, M. L ; GALANTI, G ; BERTACCINI, G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c281t-c14cb86f496290c4930c711ff932284c6a4d73a5aefdd3caa1971a8f64a4b9473</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Digestive system</topic><topic>Ethanol - toxicity</topic><topic>Gastric Mucosa - drug effects</topic><topic>Gastric Mucosa - metabolism</topic><topic>Gastric Mucosa - ultrastructure</topic><topic>Histamine Agonists - pharmacology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Methylhistamines - pharmacology</topic><topic>Microscopy, Electron</topic><topic>Microscopy, Electron, Scanning</topic><topic>Mucus - metabolism</topic><topic>Pharmacology. Drug treatments</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Receptors, Histamine H3 - drug effects</topic><topic>Receptors, Histamine H3 - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MORINI, G</creatorcontrib><creatorcontrib>GRANDI, D</creatorcontrib><creatorcontrib>ARCARI, M. L</creatorcontrib><creatorcontrib>GALANTI, G</creatorcontrib><creatorcontrib>BERTACCINI, G</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Digestive diseases and sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MORINI, G</au><au>GRANDI, D</au><au>ARCARI, M. L</au><au>GALANTI, G</au><au>BERTACCINI, G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Histological effect of (R)-α-methylhistamine on ethanol damage in rat gastric mucosa influence on mucus production</atitle><jtitle>Digestive diseases and sciences</jtitle><addtitle>Dig Dis Sci</addtitle><date>1997-05-01</date><risdate>1997</risdate><volume>42</volume><issue>5</issue><spage>1020</spage><epage>1028</epage><pages>1020-1028</pages><issn>0163-2116</issn><eissn>1573-2568</eissn><coden>DDSCDJ</coden><abstract>(R)-alpha-Methylhistamine, a selective agonist of histamine H3 receptors, prevents macroscopically visible gastric lesions by absolute ethanol in the rat. A further insight into its activity was the aim of our study. Rats were given saline or (R)-alpha-methylhistamine (100 mg/kg) intragastrically. After 30 min, absolute ethanol was given and gastric mucosa was sampled 60 min later. Histologic damage and intracellular and adherent mucus were quantified. Luminal surface and mucous cells were examined by scanning and transmission electron microscopy. (R)-alpha-Methylhistamine reduced the extent of lesions by ethanol from 96 to 18%. Surface mucous cells and mucous neck cells were increased in volume and number, packaging of intracellular mucus was modified, and the secretory processes were promoted by (R)-alpha-methylhistamine itself, although these modifications were mostly evident in stomachs subsequently exposed to ethanol. Adherent mucus layer thickness was increased by (R)-alpha-methylhistamine only after ethanol exposure. It is concluded that (R)-alpha-methylhistamine predisposes mucous cells to react to ethanol.</abstract><cop>Heidelberg</cop><pub>Springer</pub><pmid>9149057</pmid><doi>10.1023/A:1018841204104</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0163-2116 |
| ispartof | Digestive diseases and sciences, 1997-05, Vol.42 (5), p.1020-1028 |
| issn | 0163-2116 1573-2568 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Animals Biological and medical sciences Digestive system Ethanol - toxicity Gastric Mucosa - drug effects Gastric Mucosa - metabolism Gastric Mucosa - ultrastructure Histamine Agonists - pharmacology Male Medical sciences Methylhistamines - pharmacology Microscopy, Electron Microscopy, Electron, Scanning Mucus - metabolism Pharmacology. Drug treatments Rats Rats, Wistar Receptors, Histamine H3 - drug effects Receptors, Histamine H3 - physiology |
| title | Histological effect of (R)-α-methylhistamine on ethanol damage in rat gastric mucosa influence on mucus production |
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