Effects of fumonisin B1 treatment on blood-brain barrier transfer in developing rats
Fumonisin B1 (FB1), a toxic metabolite of the fungus Fusarium moniliforme found in contaminated corn, is considered an etiologic agent of equine leukoencephalomalacia. Because FB1 exposure is associated with alteration of sphingolipid metabolism, the purpose of this study was to elucidate whether bl...
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| Veröffentlicht in: | Neurotoxicology and teratology 1997-03, Vol.19 (2), p.151-155 |
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| creator | Kwon, Oh-Seung Sandberg, Jennifer A. Slikker, William |
| description | Fumonisin B1 (FB1), a toxic metabolite of the fungus Fusarium moniliforme found in contaminated corn, is considered an etiologic agent of equine leukoencephalomalacia. Because FB1 exposure is associated with alteration of sphingolipid metabolism, the purpose of this study was to elucidate whether blood sphinganine (Sa) levels affect brain Sa levels. Sa and sphingosine (So) levels in brain tissue and plasma were analyzed by HPLC. Area under the curve (AUC0 → 24h) ratios of brain Sa to plasma Sa levels were about 40 after a single 0.8 or 8 mg/kg SC dose of FB1. The AUC0 → 12h ratio of brain FB1 to plasma FB1 was 0.02. The fact that FB1 alters brain Sa levels and SaSo ratios indicates that sphingolipid metabolism in the central nervous system of developing rats is vulnerable to FB1 exposure. These data support our hypothesis that alterations of the brain Sa levels are related to the direct action of FB1 on the brain rather than transport of peripheral Sa to the brain. |
| doi_str_mv | 10.1016/S0892-0362(96)00217-6 |
| format | Article |
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Because FB1 exposure is associated with alteration of sphingolipid metabolism, the purpose of this study was to elucidate whether blood sphinganine (Sa) levels affect brain Sa levels. Sa and sphingosine (So) levels in brain tissue and plasma were analyzed by HPLC. Area under the curve (AUC0 → 24h) ratios of brain Sa to plasma Sa levels were about 40 after a single 0.8 or 8 mg/kg SC dose of FB1. The AUC0 → 12h ratio of brain FB1 to plasma FB1 was 0.02. The fact that FB1 alters brain Sa levels and SaSo ratios indicates that sphingolipid metabolism in the central nervous system of developing rats is vulnerable to FB1 exposure. These data support our hypothesis that alterations of the brain Sa levels are related to the direct action of FB1 on the brain rather than transport of peripheral Sa to the brain.</description><identifier>ISSN: 0892-0362</identifier><identifier>EISSN: 1872-9738</identifier><identifier>DOI: 10.1016/S0892-0362(96)00217-6</identifier><identifier>PMID: 9136132</identifier><identifier>CODEN: NETEEC</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Animals ; Area Under Curve ; Biological and medical sciences ; Blood-brain barrier ; Blood-Brain Barrier - drug effects ; Blood-Brain Barrier - physiology ; Carboxylic Acids - blood ; Carboxylic Acids - toxicity ; Carcinogens, Environmental - analysis ; Carcinogens, Environmental - toxicity ; Chromatography, High Pressure Liquid ; Female ; Fumonisin B1 ; Fumonisins ; Male ; Medical sciences ; Mycotoxin ; Pharmacokinetics ; Plant poisons toxicology ; Pregnancy ; Prosencephalon - chemistry ; Rats ; Rats, Sprague-Dawley ; Sphinganine ; Sphingosine ; Sphingosine - analogs & derivatives ; Sphingosine - blood ; Sphingosine - pharmacokinetics ; Toxicology</subject><ispartof>Neurotoxicology and teratology, 1997-03, Vol.19 (2), p.151-155</ispartof><rights>1997</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0892036296002176$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2643597$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9136132$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kwon, Oh-Seung</creatorcontrib><creatorcontrib>Sandberg, Jennifer A.</creatorcontrib><creatorcontrib>Slikker, William</creatorcontrib><title>Effects of fumonisin B1 treatment on blood-brain barrier transfer in developing rats</title><title>Neurotoxicology and teratology</title><addtitle>Neurotoxicol Teratol</addtitle><description>Fumonisin B1 (FB1), a toxic metabolite of the fungus Fusarium moniliforme found in contaminated corn, is considered an etiologic agent of equine leukoencephalomalacia. Because FB1 exposure is associated with alteration of sphingolipid metabolism, the purpose of this study was to elucidate whether blood sphinganine (Sa) levels affect brain Sa levels. Sa and sphingosine (So) levels in brain tissue and plasma were analyzed by HPLC. Area under the curve (AUC0 → 24h) ratios of brain Sa to plasma Sa levels were about 40 after a single 0.8 or 8 mg/kg SC dose of FB1. The AUC0 → 12h ratio of brain FB1 to plasma FB1 was 0.02. The fact that FB1 alters brain Sa levels and SaSo ratios indicates that sphingolipid metabolism in the central nervous system of developing rats is vulnerable to FB1 exposure. These data support our hypothesis that alterations of the brain Sa levels are related to the direct action of FB1 on the brain rather than transport of peripheral Sa to the brain.</description><subject>Animals</subject><subject>Area Under Curve</subject><subject>Biological and medical sciences</subject><subject>Blood-brain barrier</subject><subject>Blood-Brain Barrier - drug effects</subject><subject>Blood-Brain Barrier - physiology</subject><subject>Carboxylic Acids - blood</subject><subject>Carboxylic Acids - toxicity</subject><subject>Carcinogens, Environmental - analysis</subject><subject>Carcinogens, Environmental - toxicity</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Female</subject><subject>Fumonisin B1</subject><subject>Fumonisins</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mycotoxin</subject><subject>Pharmacokinetics</subject><subject>Plant poisons toxicology</subject><subject>Pregnancy</subject><subject>Prosencephalon - chemistry</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Sphinganine</subject><subject>Sphingosine</subject><subject>Sphingosine - analogs & derivatives</subject><subject>Sphingosine - blood</subject><subject>Sphingosine - pharmacokinetics</subject><subject>Toxicology</subject><issn>0892-0362</issn><issn>1872-9738</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kEtLAzEUhYMotVZ_QmEWLnQxepN08liJlvqAggvrOmRmbiQyj5JMC_570wdd3cs9h8s5HyFTCg8UqHj8AqVZDlywOy3uARiVuTgjY6oky7Xk6pyMT5ZLchXjLwBIQWFERppyQTkbk9XCOayGmPUuc5u273z0XfZCsyGgHVrshqzvsrLp-zovg01aaUPwGJLBdtGlJd1q3GLTr333kwU7xGty4WwT8eY4J-T7dbGav-fLz7eP-fMyRwZiyItSMimYo2AVVzMnsMbSOaVAgJBYKlE4VwAoUJJLzrXUhS5cxVXBKa0sn5Dp4e96U7ZYm3XwrQ1_5tgu6bdH3cbKNi4lrnw82ZiY8SKRmpCngw1T1m3qZmLlsauw9iGxMXXvDQWzo2721M0OqdHC7Kkbwf8BKiByXQ</recordid><startdate>199703</startdate><enddate>199703</enddate><creator>Kwon, Oh-Seung</creator><creator>Sandberg, Jennifer A.</creator><creator>Slikker, William</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>199703</creationdate><title>Effects of fumonisin B1 treatment on blood-brain barrier transfer in developing rats</title><author>Kwon, Oh-Seung ; Sandberg, Jennifer A. ; Slikker, William</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-e206t-5b72762f10a8384f6edebff8806067eb865ff50080873733979595fc385311ca3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Animals</topic><topic>Area Under Curve</topic><topic>Biological and medical sciences</topic><topic>Blood-brain barrier</topic><topic>Blood-Brain Barrier - drug effects</topic><topic>Blood-Brain Barrier - physiology</topic><topic>Carboxylic Acids - blood</topic><topic>Carboxylic Acids - toxicity</topic><topic>Carcinogens, Environmental - analysis</topic><topic>Carcinogens, Environmental - toxicity</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Female</topic><topic>Fumonisin B1</topic><topic>Fumonisins</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mycotoxin</topic><topic>Pharmacokinetics</topic><topic>Plant poisons toxicology</topic><topic>Pregnancy</topic><topic>Prosencephalon - chemistry</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Sphinganine</topic><topic>Sphingosine</topic><topic>Sphingosine - analogs & derivatives</topic><topic>Sphingosine - blood</topic><topic>Sphingosine - pharmacokinetics</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kwon, Oh-Seung</creatorcontrib><creatorcontrib>Sandberg, Jennifer A.</creatorcontrib><creatorcontrib>Slikker, William</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Neurotoxicology and teratology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kwon, Oh-Seung</au><au>Sandberg, Jennifer A.</au><au>Slikker, William</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of fumonisin B1 treatment on blood-brain barrier transfer in developing rats</atitle><jtitle>Neurotoxicology and teratology</jtitle><addtitle>Neurotoxicol Teratol</addtitle><date>1997-03</date><risdate>1997</risdate><volume>19</volume><issue>2</issue><spage>151</spage><epage>155</epage><pages>151-155</pages><issn>0892-0362</issn><eissn>1872-9738</eissn><coden>NETEEC</coden><abstract>Fumonisin B1 (FB1), a toxic metabolite of the fungus Fusarium moniliforme found in contaminated corn, is considered an etiologic agent of equine leukoencephalomalacia. Because FB1 exposure is associated with alteration of sphingolipid metabolism, the purpose of this study was to elucidate whether blood sphinganine (Sa) levels affect brain Sa levels. Sa and sphingosine (So) levels in brain tissue and plasma were analyzed by HPLC. Area under the curve (AUC0 → 24h) ratios of brain Sa to plasma Sa levels were about 40 after a single 0.8 or 8 mg/kg SC dose of FB1. The AUC0 → 12h ratio of brain FB1 to plasma FB1 was 0.02. The fact that FB1 alters brain Sa levels and SaSo ratios indicates that sphingolipid metabolism in the central nervous system of developing rats is vulnerable to FB1 exposure. These data support our hypothesis that alterations of the brain Sa levels are related to the direct action of FB1 on the brain rather than transport of peripheral Sa to the brain.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>9136132</pmid><doi>10.1016/S0892-0362(96)00217-6</doi><tpages>5</tpages></addata></record> |
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| ispartof | Neurotoxicology and teratology, 1997-03, Vol.19 (2), p.151-155 |
| issn | 0892-0362 1872-9738 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Area Under Curve Biological and medical sciences Blood-brain barrier Blood-Brain Barrier - drug effects Blood-Brain Barrier - physiology Carboxylic Acids - blood Carboxylic Acids - toxicity Carcinogens, Environmental - analysis Carcinogens, Environmental - toxicity Chromatography, High Pressure Liquid Female Fumonisin B1 Fumonisins Male Medical sciences Mycotoxin Pharmacokinetics Plant poisons toxicology Pregnancy Prosencephalon - chemistry Rats Rats, Sprague-Dawley Sphinganine Sphingosine Sphingosine - analogs & derivatives Sphingosine - blood Sphingosine - pharmacokinetics Toxicology |
| title | Effects of fumonisin B1 treatment on blood-brain barrier transfer in developing rats |
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