Use of cellulose ether containing excipients with microcrystalline cellulose for the production of pellets containing metformin hydrochloride by the process of extrusion-spheronization

Abstract The project is concerned mainly with the evaluation of two cellulose ether containing excipients, Aquacoat WG and Avicel 955 MCC for the improved extrusion-spheronization of metformin hydrochoride. Factorially designed experiments subject to statistical analyses were employed and products o...

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Veröffentlicht in:	Journal of microencapsulation 1997, Vol.14 (2), p.137-153
Hauptverfasser:	Gouldson, M. P., Deasy, P. B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aquacoat Aquacoat WG Avicel 955 MCC Biological and medical sciences Cellulose - administration & dosage Crystallization Excipients - administration & dosage extrusion General and cellular metabolism. Vitamins General pharmacology Hypoglycemic Agents - administration & dosage Medical sciences Metformin Metformin - administration & dosage pellets Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Spheroids, Cellular spheronization
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