Hepatotropic conjugate of adenine arabinoside monophosphate with lactosaminated poly- l-lysine : Synthesis of the carrier and pharmacological properties of the conjugate

Background/Aims: The hepatotropic conjugate of adenine arabinoside monophosphate with lactosaminated poly- l-lysine ( l-Poly(Lys)) must have a high solubility in order to be injected in a small volume compatible with the intramuscular route. In this paper the molecular weights of Poly(Lys) which all...

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Veröffentlicht in:	Journal of hepatology 1997-02, Vol.26 (2), p.253-259
Hauptverfasser:	Fiume, Luigi, Stefano, Giuseppina Di, Busi, Corrado, Mattioli, Alessandro, Gervasi, Gian Battista, Bertini, Marco, Bartoli, Carlo, Catalani, Robeta, Caccia, Giulio, Farina, Claudio, Fissi, Adriano, Pieroni, Osvaldo, Giuseppetti, Robert, D'Ugo, Emilio, Rapicetta, Maria
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine arabinoside monophosphate Amino Sugars - administration & dosage Animals Antiviral Agents - administration & dosage Antiviral Agents - toxicity Antiviral chemotherapy Asialoglycoprotein receptor Biological and medical sciences Drug Carriers Drug targeting Female General pharmacology Hepatitis B Hepatitis B - drug therapy Kidney - metabolism Lactosaminated poly- l-lysine Male Marmota Medical sciences Mice Pharmacology. Drug treatments Physicochemical properties. Structure-activity relationships Polylysine - administration & dosage Rats Rats, Wistar Solubility Vidarabine Phosphate - administration & dosage Vidarabine Phosphate - pharmacokinetics Vidarabine Phosphate - toxicity
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