Reconstitution of Stretch-Activated Cation Channels by Expression of the α -subunit of the Epithelial Sodium Channel Cloned from Osteoblasts

Osteoblasts respond to repetitive strain by activating stretch-activated, nonselective cation channels (SA-CAT) and increasing matrix protein production. SA-CAT channels are thought to be responsible for mechanotransduction in osteoblasts, although the molecular identity of the SA-CAT channel has pr...

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