YY1 Regulates Vitamin D Receptor/Retinoid X Receptor Mediated Transactivation of the Vitamin D responsive Osteocalcin Gene
The responsiveness of genes to steroid hormones is principally mediated by functional interactions between DNA-bound hormone receptors and components of the transcriptional initiation machinery, including TATA-binding protein, TFIIB, or other RNA polymerase II associated factors. This interaction ca...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 1997-01, Vol.94 (1), p.121-126 |
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| container_title | Proceedings of the National Academy of Sciences - PNAS |
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| creator | Guo, Bo Aslam, Fauzia Van Wijnen, André J. Stefan G. E. Roberts Frenkel, Baruch Green, Michael R. DeLuca, Hector Lian, Jane B. Stein, Gary S. Stein, Janet L. |
| description | The responsiveness of genes to steroid hormones is principally mediated by functional interactions between DNA-bound hormone receptors and components of the transcriptional initiation machinery, including TATA-binding protein, TFIIB, or other RNA polymerase II associated factors. This interaction can be physiologically modulated by promoter context-specific transcription factors to facilitate optimal responsiveness of gene expression to hormone stimulation. One postulated regulatory mechanism involves the functional antagonism between hormone receptors and nonreceptor transcription factors interacting at the same hormone response element. Here we demonstrate that the multifunctional regulator YY1 represses 1,25-dihydroxyvitamin D3 (vitamin D)-induced transactivation of the bone tissue-specific osteocalcin gene. We identify YY1 recognition sequences within the vitamin D response element (VDRE) of the osteocalcin gene that are critical for YY1-dependent repression of vitamin D-enhanced promoter activity. We show that YY1 and vitamin D receptor (VDR)/retinoid X receptor heterodimers compete for binding at the osteocalcin VDRE. In addition, we find that YY1 interacts directly with TFIIB, and that one of the two tandemly repeated polypeptide regions of TFIIB spanning the basic domain is responsible for this interaction. TFIIB and VDR can also interact directly, and these factors synergize to mediate transactivation. Our results suggest that YY1 regulates vitamin D enhancement of osteocalcin gene transcription in vivo by interfering with the interactions of the VDR with both the VDRE and TFIIB. |
| doi_str_mv | 10.1073/pnas.94.1.121 |
| format | Article |
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E. Roberts ; Frenkel, Baruch ; Green, Michael R. ; DeLuca, Hector ; Lian, Jane B. ; Stein, Gary S. ; Stein, Janet L.</creator><creatorcontrib>Guo, Bo ; Aslam, Fauzia ; Van Wijnen, André J. ; Stefan G. E. Roberts ; Frenkel, Baruch ; Green, Michael R. ; DeLuca, Hector ; Lian, Jane B. ; Stein, Gary S. ; Stein, Janet L.</creatorcontrib><description>The responsiveness of genes to steroid hormones is principally mediated by functional interactions between DNA-bound hormone receptors and components of the transcriptional initiation machinery, including TATA-binding protein, TFIIB, or other RNA polymerase II associated factors. This interaction can be physiologically modulated by promoter context-specific transcription factors to facilitate optimal responsiveness of gene expression to hormone stimulation. One postulated regulatory mechanism involves the functional antagonism between hormone receptors and nonreceptor transcription factors interacting at the same hormone response element. Here we demonstrate that the multifunctional regulator YY1 represses 1,25-dihydroxyvitamin D3 (vitamin D)-induced transactivation of the bone tissue-specific osteocalcin gene. We identify YY1 recognition sequences within the vitamin D response element (VDRE) of the osteocalcin gene that are critical for YY1-dependent repression of vitamin D-enhanced promoter activity. We show that YY1 and vitamin D receptor (VDR)/retinoid X receptor heterodimers compete for binding at the osteocalcin VDRE. In addition, we find that YY1 interacts directly with TFIIB, and that one of the two tandemly repeated polypeptide regions of TFIIB spanning the basic domain is responsible for this interaction. TFIIB and VDR can also interact directly, and these factors synergize to mediate transactivation. Our results suggest that YY1 regulates vitamin D enhancement of osteocalcin gene transcription in vivo by interfering with the interactions of the VDR with both the VDRE and TFIIB.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.94.1.121</identifier><identifier>PMID: 8990171</identifier><language>eng</language><publisher>United States: National Academy of Sciences of the United States of America</publisher><subject>Animals ; Binding Sites ; Binding, Competitive ; Biochemistry ; Biological Sciences ; Bone and Bones - drug effects ; Bone and Bones - metabolism ; Bones ; DNA ; DNA-Binding Proteins - metabolism ; Erythroid-Specific DNA-Binding Factors ; Gene expression ; Genes ; Models, Genetic ; Nuclear Proteins - metabolism ; Oligonucleotides ; Osteocalcin - biosynthesis ; Osteocalcin - genetics ; Osteosarcoma ; Plasmids ; Rats ; Receptors ; Receptors, Calcitriol - metabolism ; Receptors, Retinoic Acid - metabolism ; Recombinant Proteins - metabolism ; Repression ; Retinoid X Receptors ; Steroids ; Transactivation ; Transcription Factor TFIIB ; Transcription Factors - metabolism ; Transcriptional Activation ; Transfection ; Tumor Cells, Cultured ; Vitamin D ; Vitamin D - pharmacology ; YY1 Transcription Factor</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 1997-01, Vol.94 (1), p.121-126</ispartof><rights>Copyright 1997 National Academy of Sciences</rights><rights>Copyright National Academy of Sciences Jan 7, 1997</rights><rights>Copyright © 1997, The National Academy of Sciences of the USA 1997</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c510t-d102cb4c1ce02d12bde78dda96eed01d93c7ec7d5538b9532c9c60b1a260e94d3</citedby><cites>FETCH-LOGICAL-c510t-d102cb4c1ce02d12bde78dda96eed01d93c7ec7d5538b9532c9c60b1a260e94d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.pnas.org/content/94/1.cover.gif</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/41458$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/41458$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,723,776,780,799,881,27901,27902,53766,53768,57992,58225</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8990171$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Guo, Bo</creatorcontrib><creatorcontrib>Aslam, Fauzia</creatorcontrib><creatorcontrib>Van Wijnen, André J.</creatorcontrib><creatorcontrib>Stefan G. E. Roberts</creatorcontrib><creatorcontrib>Frenkel, Baruch</creatorcontrib><creatorcontrib>Green, Michael R.</creatorcontrib><creatorcontrib>DeLuca, Hector</creatorcontrib><creatorcontrib>Lian, Jane B.</creatorcontrib><creatorcontrib>Stein, Gary S.</creatorcontrib><creatorcontrib>Stein, Janet L.</creatorcontrib><title>YY1 Regulates Vitamin D Receptor/Retinoid X Receptor Mediated Transactivation of the Vitamin D responsive Osteocalcin Gene</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>The responsiveness of genes to steroid hormones is principally mediated by functional interactions between DNA-bound hormone receptors and components of the transcriptional initiation machinery, including TATA-binding protein, TFIIB, or other RNA polymerase II associated factors. This interaction can be physiologically modulated by promoter context-specific transcription factors to facilitate optimal responsiveness of gene expression to hormone stimulation. One postulated regulatory mechanism involves the functional antagonism between hormone receptors and nonreceptor transcription factors interacting at the same hormone response element. Here we demonstrate that the multifunctional regulator YY1 represses 1,25-dihydroxyvitamin D3 (vitamin D)-induced transactivation of the bone tissue-specific osteocalcin gene. We identify YY1 recognition sequences within the vitamin D response element (VDRE) of the osteocalcin gene that are critical for YY1-dependent repression of vitamin D-enhanced promoter activity. We show that YY1 and vitamin D receptor (VDR)/retinoid X receptor heterodimers compete for binding at the osteocalcin VDRE. In addition, we find that YY1 interacts directly with TFIIB, and that one of the two tandemly repeated polypeptide regions of TFIIB spanning the basic domain is responsible for this interaction. TFIIB and VDR can also interact directly, and these factors synergize to mediate transactivation. Our results suggest that YY1 regulates vitamin D enhancement of osteocalcin gene transcription in vivo by interfering with the interactions of the VDR with both the VDRE and TFIIB.</description><subject>Animals</subject><subject>Binding Sites</subject><subject>Binding, Competitive</subject><subject>Biochemistry</subject><subject>Biological Sciences</subject><subject>Bone and Bones - drug effects</subject><subject>Bone and Bones - metabolism</subject><subject>Bones</subject><subject>DNA</subject><subject>DNA-Binding Proteins - metabolism</subject><subject>Erythroid-Specific DNA-Binding Factors</subject><subject>Gene expression</subject><subject>Genes</subject><subject>Models, Genetic</subject><subject>Nuclear Proteins - metabolism</subject><subject>Oligonucleotides</subject><subject>Osteocalcin - biosynthesis</subject><subject>Osteocalcin - genetics</subject><subject>Osteosarcoma</subject><subject>Plasmids</subject><subject>Rats</subject><subject>Receptors</subject><subject>Receptors, Calcitriol - metabolism</subject><subject>Receptors, Retinoic Acid - metabolism</subject><subject>Recombinant Proteins - metabolism</subject><subject>Repression</subject><subject>Retinoid X Receptors</subject><subject>Steroids</subject><subject>Transactivation</subject><subject>Transcription Factor TFIIB</subject><subject>Transcription Factors - metabolism</subject><subject>Transcriptional Activation</subject><subject>Transfection</subject><subject>Tumor Cells, Cultured</subject><subject>Vitamin D</subject><subject>Vitamin D - pharmacology</subject><subject>YY1 Transcription Factor</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFks9rFDEYhoModa0evYjCIOhttvkyP5KAF6lahUqhVLGnkEm-bbPMJtNJZlH_erPsuqwe9BT4nucNSd4Q8hToHCivTgav41zWc5gDg3tkBlRC2daS3iczShkvRc3qh-RRjEtKqWwEPSJHQkoKHGbk5_U1FJd4M_U6YSy-uqRXzhfv8szgkMJ4conJ-eBs8W0_Kz6jddm3xdWofdQmubVOLvgiLIp0iwfbjBiH4KNbY3EREwaje5PBGXp8TB4sdB_xyW49Jl8-vL86_VieX5x9On17XpoGaCotUGa62oBByiywziIX1mrZIloKVlaGo-G2aSrRyaZiRpqWdqBZS1HWtjomb7b7DlO3QmvQp1H3ahjdSo8_VNBO_Um8u1U3Ya1Asobl-OtdfAx3E8akVi4a7HvtMUxRccEFMMH_K0IjWsFlncWXf4nLMI0-v4FiFCrOWQVZKreSGUOMIy72BwaqNsWrTfFK1gpULj77Lw5vubd3TWf-fMc3sd_0IP7qH1gtpr5P-D1l79nWW8b8EfZiDXUjql_KxMu-</recordid><startdate>19970107</startdate><enddate>19970107</enddate><creator>Guo, Bo</creator><creator>Aslam, Fauzia</creator><creator>Van Wijnen, André J.</creator><creator>Stefan G. 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E. Roberts</au><au>Frenkel, Baruch</au><au>Green, Michael R.</au><au>DeLuca, Hector</au><au>Lian, Jane B.</au><au>Stein, Gary S.</au><au>Stein, Janet L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>YY1 Regulates Vitamin D Receptor/Retinoid X Receptor Mediated Transactivation of the Vitamin D responsive Osteocalcin Gene</atitle><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle><addtitle>Proc Natl Acad Sci U S A</addtitle><date>1997-01-07</date><risdate>1997</risdate><volume>94</volume><issue>1</issue><spage>121</spage><epage>126</epage><pages>121-126</pages><issn>0027-8424</issn><eissn>1091-6490</eissn><abstract>The responsiveness of genes to steroid hormones is principally mediated by functional interactions between DNA-bound hormone receptors and components of the transcriptional initiation machinery, including TATA-binding protein, TFIIB, or other RNA polymerase II associated factors. This interaction can be physiologically modulated by promoter context-specific transcription factors to facilitate optimal responsiveness of gene expression to hormone stimulation. One postulated regulatory mechanism involves the functional antagonism between hormone receptors and nonreceptor transcription factors interacting at the same hormone response element. Here we demonstrate that the multifunctional regulator YY1 represses 1,25-dihydroxyvitamin D3 (vitamin D)-induced transactivation of the bone tissue-specific osteocalcin gene. We identify YY1 recognition sequences within the vitamin D response element (VDRE) of the osteocalcin gene that are critical for YY1-dependent repression of vitamin D-enhanced promoter activity. We show that YY1 and vitamin D receptor (VDR)/retinoid X receptor heterodimers compete for binding at the osteocalcin VDRE. In addition, we find that YY1 interacts directly with TFIIB, and that one of the two tandemly repeated polypeptide regions of TFIIB spanning the basic domain is responsible for this interaction. TFIIB and VDR can also interact directly, and these factors synergize to mediate transactivation. Our results suggest that YY1 regulates vitamin D enhancement of osteocalcin gene transcription in vivo by interfering with the interactions of the VDR with both the VDRE and TFIIB.</abstract><cop>United States</cop><pub>National Academy of Sciences of the United States of America</pub><pmid>8990171</pmid><doi>10.1073/pnas.94.1.121</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Proceedings of the National Academy of Sciences - PNAS, 1997-01, Vol.94 (1), p.121-126 |
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| source | Jstor Complete Legacy; MEDLINE; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | Animals Binding Sites Binding, Competitive Biochemistry Biological Sciences Bone and Bones - drug effects Bone and Bones - metabolism Bones DNA DNA-Binding Proteins - metabolism Erythroid-Specific DNA-Binding Factors Gene expression Genes Models, Genetic Nuclear Proteins - metabolism Oligonucleotides Osteocalcin - biosynthesis Osteocalcin - genetics Osteosarcoma Plasmids Rats Receptors Receptors, Calcitriol - metabolism Receptors, Retinoic Acid - metabolism Recombinant Proteins - metabolism Repression Retinoid X Receptors Steroids Transactivation Transcription Factor TFIIB Transcription Factors - metabolism Transcriptional Activation Transfection Tumor Cells, Cultured Vitamin D Vitamin D - pharmacology YY1 Transcription Factor |
| title | YY1 Regulates Vitamin D Receptor/Retinoid X Receptor Mediated Transactivation of the Vitamin D responsive Osteocalcin Gene |
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