Antibacterial activities of combination uses of isepamicin and beta-lactams in vitro against clinically isolated strains. Part 2. The results against enterobacteriaceae
We investigated antibacterial activities of combination uses of isepamicin (ISP) and beta-lactams in vitro against Klebsiella pneumoniae and Enterobacter cloacae, and the following conclusions were obtained. 1. ISP+cefazolin, ISP+cefotiam and ISP+flomoxef against K. pneumoniae and ISP+piperacillin,...
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| Veröffentlicht in: | Japanese journal of antibiotics 1996-03, Vol.49 (3), p.279 |
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| container_title | Japanese journal of antibiotics |
| container_volume | 49 |
| creator | Deguchi, K Koguchi, M Suzuki, Y Tanaka, S Fukayama, S Ishihara, R Oda, S |
| description | We investigated antibacterial activities of combination uses of isepamicin (ISP) and beta-lactams in vitro against Klebsiella pneumoniae and Enterobacter cloacae, and the following conclusions were obtained. 1. ISP+cefazolin, ISP+cefotiam and ISP+flomoxef against K. pneumoniae and ISP+piperacillin, ISP+ceftazidime, ISP+aztreonam, ISP+imipenem and ISP+panipenem against E. cloacae showed strong combined effects. 2. The minimum inhibitory concentrations (MICs) of these combinations were low due to the dependence of ISP concentrations. Strong antibacterial activities were observed at sub-MIC levels of ISP. These combined effects were stronger than those against Staphylococcus aureus described in the first report at sub-MIC levels of ISP. 1/4 MIC approximately 1/8 MIC of ISP showed enhanced activities of beta-lactams. Similarly strong combined effects were observed against both beta-lactam-sensitive and -resistant strains. |
| doi_str_mv | 10.11553/antibiotics1968b.49.279 |
| format | Article |
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Part 2. The results against enterobacteriaceae</title><source>MEDLINE</source><source>Free E-Journal (出版社公開部分のみ）</source><creator>Deguchi, K ; Koguchi, M ; Suzuki, Y ; Tanaka, S ; Fukayama, S ; Ishihara, R ; Oda, S</creator><creatorcontrib>Deguchi, K ; Koguchi, M ; Suzuki, Y ; Tanaka, S ; Fukayama, S ; Ishihara, R ; Oda, S</creatorcontrib><description>We investigated antibacterial activities of combination uses of isepamicin (ISP) and beta-lactams in vitro against Klebsiella pneumoniae and Enterobacter cloacae, and the following conclusions were obtained. 1. ISP+cefazolin, ISP+cefotiam and ISP+flomoxef against K. pneumoniae and ISP+piperacillin, ISP+ceftazidime, ISP+aztreonam, ISP+imipenem and ISP+panipenem against E. cloacae showed strong combined effects. 2. The minimum inhibitory concentrations (MICs) of these combinations were low due to the dependence of ISP concentrations. Strong antibacterial activities were observed at sub-MIC levels of ISP. These combined effects were stronger than those against Staphylococcus aureus described in the first report at sub-MIC levels of ISP. 1/4 MIC approximately 1/8 MIC of ISP showed enhanced activities of beta-lactams. Similarly strong combined effects were observed against both beta-lactam-sensitive and -resistant strains.</description><identifier>ISSN: 0368-2781</identifier><identifier>DOI: 10.11553/antibiotics1968b.49.279</identifier><identifier>PMID: 8935124</identifier><language>eng ; jpn</language><publisher>Japan</publisher><subject>Anti-Bacterial Agents - pharmacology ; beta-Lactams ; Drug Synergism ; Enterobacter cloacae - drug effects ; Enterobacteriaceae - drug effects ; Enterobacteriaceae - isolation & purification ; Gentamicins - pharmacology ; Humans ; Klebsiella pneumoniae - drug effects ; Microbial Sensitivity Tests</subject><ispartof>Japanese journal of antibiotics, 1996-03, Vol.49 (3), p.279</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8935124$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Deguchi, K</creatorcontrib><creatorcontrib>Koguchi, M</creatorcontrib><creatorcontrib>Suzuki, Y</creatorcontrib><creatorcontrib>Tanaka, S</creatorcontrib><creatorcontrib>Fukayama, S</creatorcontrib><creatorcontrib>Ishihara, R</creatorcontrib><creatorcontrib>Oda, S</creatorcontrib><title>Antibacterial activities of combination uses of isepamicin and beta-lactams in vitro against clinically isolated strains. Part 2. The results against enterobacteriaceae</title><title>Japanese journal of antibiotics</title><addtitle>Jpn J Antibiot</addtitle><description>We investigated antibacterial activities of combination uses of isepamicin (ISP) and beta-lactams in vitro against Klebsiella pneumoniae and Enterobacter cloacae, and the following conclusions were obtained. 1. ISP+cefazolin, ISP+cefotiam and ISP+flomoxef against K. pneumoniae and ISP+piperacillin, ISP+ceftazidime, ISP+aztreonam, ISP+imipenem and ISP+panipenem against E. cloacae showed strong combined effects. 2. The minimum inhibitory concentrations (MICs) of these combinations were low due to the dependence of ISP concentrations. Strong antibacterial activities were observed at sub-MIC levels of ISP. These combined effects were stronger than those against Staphylococcus aureus described in the first report at sub-MIC levels of ISP. 1/4 MIC approximately 1/8 MIC of ISP showed enhanced activities of beta-lactams. Similarly strong combined effects were observed against both beta-lactam-sensitive and -resistant strains.</description><subject>Anti-Bacterial Agents - pharmacology</subject><subject>beta-Lactams</subject><subject>Drug Synergism</subject><subject>Enterobacter cloacae - drug effects</subject><subject>Enterobacteriaceae - drug effects</subject><subject>Enterobacteriaceae - isolation & purification</subject><subject>Gentamicins - pharmacology</subject><subject>Humans</subject><subject>Klebsiella pneumoniae - drug effects</subject><subject>Microbial Sensitivity Tests</subject><issn>0368-2781</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kM1qwzAQhHVoSUOaRyjoBexaP07kYwj9g0B7yD2spHW7IMvGUgp5oz5mHZL2NMsM3zIMY1xUpRB1rR4hZrLUZ3JJNCtjS92Uct3csHmlVqaQayPu2DIlslUljRRNU8_YzDSqFlLP2c_mzIPLOBIEPh30TZkw8b7lru8sRcjUR35MF48SDtCRo8ghem4xQxEmDLrEJ2-Cx57DJ1BMmbtAkRyEcJq4PkBGz1Mez2HJP2DMXJZ8_4V8xHQMOf2DGKdC_V8vh4D37LaFkHB51QXbPz_tt6_F7v3lbbvZFYOQIhetAYXOmZXULZpW13WrpfAWZWvsGqXR1rtaSWOcqkzllVGI3lVKC-0B1YI9XN4OR9uhPwwjdTCeDtfB1C82L3Vk</recordid><startdate>199603</startdate><enddate>199603</enddate><creator>Deguchi, K</creator><creator>Koguchi, M</creator><creator>Suzuki, Y</creator><creator>Tanaka, S</creator><creator>Fukayama, S</creator><creator>Ishihara, R</creator><creator>Oda, S</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>199603</creationdate><title>Antibacterial activities of combination uses of isepamicin and beta-lactams in vitro against clinically isolated strains. 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Part 2. The results against enterobacteriaceae</atitle><jtitle>Japanese journal of antibiotics</jtitle><addtitle>Jpn J Antibiot</addtitle><date>1996-03</date><risdate>1996</risdate><volume>49</volume><issue>3</issue><spage>279</spage><pages>279-</pages><issn>0368-2781</issn><abstract>We investigated antibacterial activities of combination uses of isepamicin (ISP) and beta-lactams in vitro against Klebsiella pneumoniae and Enterobacter cloacae, and the following conclusions were obtained. 1. ISP+cefazolin, ISP+cefotiam and ISP+flomoxef against K. pneumoniae and ISP+piperacillin, ISP+ceftazidime, ISP+aztreonam, ISP+imipenem and ISP+panipenem against E. cloacae showed strong combined effects. 2. The minimum inhibitory concentrations (MICs) of these combinations were low due to the dependence of ISP concentrations. Strong antibacterial activities were observed at sub-MIC levels of ISP. These combined effects were stronger than those against Staphylococcus aureus described in the first report at sub-MIC levels of ISP. 1/4 MIC approximately 1/8 MIC of ISP showed enhanced activities of beta-lactams. Similarly strong combined effects were observed against both beta-lactam-sensitive and -resistant strains.</abstract><cop>Japan</cop><pmid>8935124</pmid><doi>10.11553/antibiotics1968b.49.279</doi></addata></record> |
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| identifier | ISSN: 0368-2781 |
| ispartof | Japanese journal of antibiotics, 1996-03, Vol.49 (3), p.279 |
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| language | eng ; jpn |
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| source | MEDLINE; Free E-Journal (出版社公開部分のみ） |
| subjects | Anti-Bacterial Agents - pharmacology beta-Lactams Drug Synergism Enterobacter cloacae - drug effects Enterobacteriaceae - drug effects Enterobacteriaceae - isolation & purification Gentamicins - pharmacology Humans Klebsiella pneumoniae - drug effects Microbial Sensitivity Tests |
| title | Antibacterial activities of combination uses of isepamicin and beta-lactams in vitro against clinically isolated strains. Part 2. The results against enterobacteriaceae |
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