COMPARATIVE STUDY ON THE EFFICACY OF RITIPENEM ACOXIL AND CEFOTIAM HEXETIL IN CHRONIC LOWER RESPIRATORY TRACT INFECTIONS BY THE DOUBLE-BLIND METHOD
To objectively evaluate the efficacy, safety and usefulness of the newly developed penem oral antibiotic, ritipenem acoxil (RIPM-AC), against chronic lower respiratory tract infections, we conducted a multi-center double-blind comparative study using cefotiam hexetil (CTM-HE) as a control drug. RIPM...
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| Veröffentlicht in: | Japanese journal of antibiotics 1996/03/25, Vol.49(3), pp.219-249 |
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| creator | KAWAKAMI, YOSHIKAZU ABE, SHOSAKU OHMICHI, MITSUHIDE INOUE, HIROSHI YOSHIDA, MASAMI KOBAYASHI, HITOSHI ITO, TAKASHI BANDO, TAKESHI TAKEUCHI, KENICHI HIRANO, HARUTO TANNO, YASUO SAKAMOTO, MASAHIRO NUKIWA, TOSHIHIRO YANASE, KENJI ITO, NOBUO FUKUDA, KIYOSHI KOBA, HIROYUKIYASHI WATANABE, HIDEHIRO INAMATSU, TAKASHI SANO, YASUYUKI KURAKI, TAKASHIGE SHISHIDO, HARUMI TANOUE, SHOKO KOYAMA, MASARU KUDO, KOICHIRO KOSHINO, TAKESHI OKUBO, TAKAO TANI, KENJI SHOJI, AKIRA CHIBA, JUN IKEHARA, KUNIHIKO SAKURAI, IWAO TAKAHASHI, HIROSHI ARAKAWA, MASAAKI WADA, KOICHI IWATA, FUMIHIDE TSUKADA, HIROKI SUZUKI, YASUTOSHI SATO, ATSUHIKO IWATA, MASATOSHI SHICHI, IZUMI YASUDA, KAZUMASA TAKAGI, KENZO WATANABE, YOSHIAKI TANIGUCHI, HIROYUKI USUI, ISAO BANDO, KENJI KISHIMOTO, TADAMITSU IKEDA, AKINORI OKUMOTO, TAKESHI MIKI, FUMIO OKAWA, KENTARO MIKASA, KEIICHI HIGASHINO, KAZUYA MAEBO, AKIO NOMURA, SHIGEO YAMAGUCHI, KAZUYUKI HIRABAYASHI, MASATAKA YOSHIDA, MASAO MATSUSHIMA, TOSHIHARU MATSUMOTO, YUKIO ISHIOKA, SHINICHI KUWAHARA, MASAO MOCHIZUKI, NOBUHIRO YANAGIDA, JITSURO ARITA, KENICHI DAIDO, KAZUHIRO EJIMA, TSUYOSHI MIKI, SATOSHI SAWAE, YOSHIRO YOSHIDA, MINORU SHIRAISHI, TSUNEAKI KAWAHARA, MASASHI KAWAYAMA, TOMOTAKA HONDA, YOSHIAKI ISHIBASHI, TSUNEO TAKAMOTO, MASAHIRO KAJIKI, AKIRA FUJISAWA, NOBUMITSU SUGA, MORITAKA DOI, TOSHINORI TAKENAKA, SHINOBU HARA, KOHEI KOHNO, SHIGERU KAKU, MITSUO INOUE, YUICHI YAMASHITA, YUKO SAKATA, SHINGO FUJII, TAKESHI IRIFUNE, KENJI MIYAZAKI, YOSHITSUGU WATANABE, TAKASHI MATSUMOTO, KEIZO AKIYAMA, MORITOSHI NAKAMA, KAORU MATSUKURA, SHIGERU MASHIMOTO, HIDEO MUKAE, HIROSHI DEGUCHI, KOICHI NAKASHIMA, MITSUYOSHI |
| description | To objectively evaluate the efficacy, safety and usefulness of the newly developed penem oral antibiotic, ritipenem acoxil (RIPM-AC), against chronic lower respiratory tract infections, we conducted a multi-center double-blind comparative study using cefotiam hexetil (CTM-HE) as a control drug. RIPM-AC was orally administered at 200 mg, and CTM-HE at 400 mg, t.i.d. for 14 days, in principle. The results were as follows: The total number of patients enrol led in this trial was 202, of which 151 cases (RIPM-AC group: 75, CTM-HE group: 76) were evaluable for clinical efficacy. 1. The clinical efficacy rates (excellent+good) were 85.3% (64/75) in the RIPM-AC group and 80.3% (61/76) in the CTM-HE group. There was no significant difference between the two groups, hence the clinical equivalency of RIPM-AC to CTM-HE was demonstrated. 2. In the patients enrolled in the evaluation of clinical efficacy, the eradication rates of the causative organisms were 50.0% (13/26) in the RIPM-AC group and 75.0% (18/24) in the CTM-HE group, with no significant difference between the two groups. 3. Side effects were noted in 10 cases (11.0%) of the RIPM-AC group and 10 cases (10.9%) of the CTM-HE group. Abnormal laboratory test findings were observed in 8 cases(9.5%) of the RIPM-AC group and in 14 cases (16.7%) of the CTM-HE group. There were no significant differences between the two groups in the incidence of side effects and abnormal laboratory test findings. In the safety evaluation, RIPM-AC was judged to be safe in 73 cases (80.2%) and CTM-HE in 71 cases (77.2%), with no significant difference. 4. The usefulness rates (markedly useful+useful) were 79.5% (62/78) in the RIPM-AC group and 76.9% (60/78) in the CTM-HE group. There was no significant difference between the two groups. Since RIPM-AC showed clinical efficacy similar to those of CTM-HE and posed no particular safety problems, it is expected to be a useful antibiotic for the treatment of chronic lower respiratory tract infCctions. |
| doi_str_mv | 10.11553/antibiotics1968b.49.219 |
| format | Article |
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SAKAMOTO, MASAHIRO ; NUKIWA, TOSHIHIRO ; YANASE, KENJI ; ITO, NOBUO ; FUKUDA, KIYOSHI ; KOBA, HIROYUKIYASHI ; WATANABE, HIDEHIRO ; INAMATSU, TAKASHI ; SANO, YASUYUKI ; KURAKI, TAKASHIGE ; SHISHIDO, HARUMI ; TANOUE, SHOKO ; KOYAMA, MASARU ; KUDO, KOICHIRO ; KOSHINO, TAKESHI ; OKUBO, TAKAO ; TANI, KENJI ; SHOJI, AKIRA ; CHIBA, JUN ; IKEHARA, KUNIHIKO ; SAKURAI, IWAO ; TAKAHASHI, HIROSHI ; ARAKAWA, MASAAKI ; WADA, KOICHI ; IWATA, FUMIHIDE ; TSUKADA, HIROKI ; SUZUKI, YASUTOSHI ; SATO, ATSUHIKO ; IWATA, MASATOSHI ; SHICHI, IZUMI ; YASUDA, KAZUMASA ; TAKAGI, KENZO ; WATANABE, YOSHIAKI ; TANIGUCHI, HIROYUKI ; USUI, ISAO ; BANDO, KENJI ; KISHIMOTO, TADAMITSU ; IKEDA, AKINORI ; OKUMOTO, TAKESHI ; MIKI, FUMIO ; OKAWA, KENTARO ; MIKASA, KEIICHI ; HIGASHINO, KAZUYA ; MAEBO, AKIO ; NOMURA, SHIGEO ; YAMAGUCHI, KAZUYUKI ; HIRABAYASHI, MASATAKA ; YOSHIDA, MASAO ; MATSUSHIMA, TOSHIHARU ; MATSUMOTO, YUKIO ; ISHIOKA, SHINICHI ; KUWAHARA, MASAO ; MOCHIZUKI, NOBUHIRO ; YANAGIDA, JITSURO ; ARITA, KENICHI ; DAIDO, KAZUHIRO ; EJIMA, TSUYOSHI ; MIKI, SATOSHI ; SAWAE, YOSHIRO ; YOSHIDA, MINORU ; SHIRAISHI, TSUNEAKI ; KAWAHARA, MASASHI ; KAWAYAMA, TOMOTAKA ; HONDA, YOSHIAKI ; ISHIBASHI, TSUNEO ; TAKAMOTO, MASAHIRO ; KAJIKI, AKIRA ; FUJISAWA, NOBUMITSU ; SUGA, MORITAKA ; DOI, TOSHINORI ; TAKENAKA, SHINOBU ; HARA, KOHEI ; KOHNO, SHIGERU ; KAKU, MITSUO ; INOUE, YUICHI ; YAMASHITA, YUKO ; SAKATA, SHINGO ; FUJII, TAKESHI ; IRIFUNE, KENJI ; MIYAZAKI, YOSHITSUGU ; WATANABE, TAKASHI ; MATSUMOTO, KEIZO ; AKIYAMA, MORITOSHI ; NAKAMA, KAORU ; MATSUKURA, SHIGERU ; MASHIMOTO, HIDEO ; MUKAE, HIROSHI ; DEGUCHI, KOICHI ; NAKASHIMA, MITSUYOSHI</creatorcontrib><description>To objectively evaluate the efficacy, safety and usefulness of the newly developed penem oral antibiotic, ritipenem acoxil (RIPM-AC), against chronic lower respiratory tract infections, we conducted a multi-center double-blind comparative study using cefotiam hexetil (CTM-HE) as a control drug. RIPM-AC was orally administered at 200 mg, and CTM-HE at 400 mg, t.i.d. for 14 days, in principle. The results were as follows: The total number of patients enrol led in this trial was 202, of which 151 cases (RIPM-AC group: 75, CTM-HE group: 76) were evaluable for clinical efficacy. 1. The clinical efficacy rates (excellent+good) were 85.3% (64/75) in the RIPM-AC group and 80.3% (61/76) in the CTM-HE group. There was no significant difference between the two groups, hence the clinical equivalency of RIPM-AC to CTM-HE was demonstrated. 2. In the patients enrolled in the evaluation of clinical efficacy, the eradication rates of the causative organisms were 50.0% (13/26) in the RIPM-AC group and 75.0% (18/24) in the CTM-HE group, with no significant difference between the two groups. 3. Side effects were noted in 10 cases (11.0%) of the RIPM-AC group and 10 cases (10.9%) of the CTM-HE group. Abnormal laboratory test findings were observed in 8 cases(9.5%) of the RIPM-AC group and in 14 cases (16.7%) of the CTM-HE group. There were no significant differences between the two groups in the incidence of side effects and abnormal laboratory test findings. In the safety evaluation, RIPM-AC was judged to be safe in 73 cases (80.2%) and CTM-HE in 71 cases (77.2%), with no significant difference. 4. The usefulness rates (markedly useful+useful) were 79.5% (62/78) in the RIPM-AC group and 76.9% (60/78) in the CTM-HE group. There was no significant difference between the two groups. Since RIPM-AC showed clinical efficacy similar to those of CTM-HE and posed no particular safety problems, it is expected to be a useful antibiotic for the treatment of chronic lower respiratory tract infCctions.</description><identifier>ISSN: 0368-2781</identifier><identifier>EISSN: 2186-5477</identifier><identifier>DOI: 10.11553/antibiotics1968b.49.219</identifier><identifier>PMID: 8935119</identifier><language>jpn</language><publisher>Japan: Japan Antibiotics Research Association</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Bacterial Infections - drug therapy ; Bacterial Infections - microbiology ; Carbapenems - adverse effects ; Carbapenems - therapeutic use ; Cefotiam - adverse effects ; Cefotiam - therapeutic use ; Cephalosporins - adverse effects ; Cephalosporins - therapeutic use ; Chronic Disease ; Double-Blind Method ; Female ; Humans ; Japan ; Male ; Middle Aged ; Respiratory Tract Infections - drug therapy ; Respiratory Tract Infections - microbiology</subject><ispartof>The Japanese Journal of Antibiotics, 1996/03/25, Vol.49(3), pp.219-249</ispartof><rights>Japan Antibiotics Research Association</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8935119$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KAWAKAMI, YOSHIKAZU</creatorcontrib><creatorcontrib>ABE, SHOSAKU</creatorcontrib><creatorcontrib>OHMICHI, MITSUHIDE</creatorcontrib><creatorcontrib>INOUE, HIROSHI</creatorcontrib><creatorcontrib>YOSHIDA, MASAMI</creatorcontrib><creatorcontrib>KOBAYASHI, HITOSHI</creatorcontrib><creatorcontrib>ITO, TAKASHI</creatorcontrib><creatorcontrib>BANDO, TAKESHI</creatorcontrib><creatorcontrib>TAKEUCHI, KENICHI</creatorcontrib><creatorcontrib>HIRANO, HARUTO</creatorcontrib><creatorcontrib>TANNO, YASUO</creatorcontrib><creatorcontrib>SAKAMOTO, MASAHIRO</creatorcontrib><creatorcontrib>NUKIWA, TOSHIHIRO</creatorcontrib><creatorcontrib>YANASE, KENJI</creatorcontrib><creatorcontrib>ITO, NOBUO</creatorcontrib><creatorcontrib>FUKUDA, KIYOSHI</creatorcontrib><creatorcontrib>KOBA, HIROYUKIYASHI</creatorcontrib><creatorcontrib>WATANABE, HIDEHIRO</creatorcontrib><creatorcontrib>INAMATSU, TAKASHI</creatorcontrib><creatorcontrib>SANO, YASUYUKI</creatorcontrib><creatorcontrib>KURAKI, TAKASHIGE</creatorcontrib><creatorcontrib>SHISHIDO, HARUMI</creatorcontrib><creatorcontrib>TANOUE, SHOKO</creatorcontrib><creatorcontrib>KOYAMA, MASARU</creatorcontrib><creatorcontrib>KUDO, KOICHIRO</creatorcontrib><creatorcontrib>KOSHINO, TAKESHI</creatorcontrib><creatorcontrib>OKUBO, TAKAO</creatorcontrib><creatorcontrib>TANI, KENJI</creatorcontrib><creatorcontrib>SHOJI, AKIRA</creatorcontrib><creatorcontrib>CHIBA, JUN</creatorcontrib><creatorcontrib>IKEHARA, KUNIHIKO</creatorcontrib><creatorcontrib>SAKURAI, IWAO</creatorcontrib><creatorcontrib>TAKAHASHI, HIROSHI</creatorcontrib><creatorcontrib>ARAKAWA, MASAAKI</creatorcontrib><creatorcontrib>WADA, KOICHI</creatorcontrib><creatorcontrib>IWATA, FUMIHIDE</creatorcontrib><creatorcontrib>TSUKADA, HIROKI</creatorcontrib><creatorcontrib>SUZUKI, YASUTOSHI</creatorcontrib><creatorcontrib>SATO, ATSUHIKO</creatorcontrib><creatorcontrib>IWATA, MASATOSHI</creatorcontrib><creatorcontrib>SHICHI, IZUMI</creatorcontrib><creatorcontrib>YASUDA, KAZUMASA</creatorcontrib><creatorcontrib>TAKAGI, KENZO</creatorcontrib><creatorcontrib>WATANABE, YOSHIAKI</creatorcontrib><creatorcontrib>TANIGUCHI, HIROYUKI</creatorcontrib><creatorcontrib>USUI, ISAO</creatorcontrib><creatorcontrib>BANDO, KENJI</creatorcontrib><creatorcontrib>KISHIMOTO, TADAMITSU</creatorcontrib><creatorcontrib>IKEDA, AKINORI</creatorcontrib><creatorcontrib>OKUMOTO, TAKESHI</creatorcontrib><creatorcontrib>MIKI, FUMIO</creatorcontrib><creatorcontrib>OKAWA, KENTARO</creatorcontrib><creatorcontrib>MIKASA, KEIICHI</creatorcontrib><creatorcontrib>HIGASHINO, KAZUYA</creatorcontrib><creatorcontrib>MAEBO, AKIO</creatorcontrib><creatorcontrib>NOMURA, SHIGEO</creatorcontrib><creatorcontrib>YAMAGUCHI, KAZUYUKI</creatorcontrib><creatorcontrib>HIRABAYASHI, MASATAKA</creatorcontrib><creatorcontrib>YOSHIDA, MASAO</creatorcontrib><creatorcontrib>MATSUSHIMA, TOSHIHARU</creatorcontrib><creatorcontrib>MATSUMOTO, YUKIO</creatorcontrib><creatorcontrib>ISHIOKA, SHINICHI</creatorcontrib><creatorcontrib>KUWAHARA, MASAO</creatorcontrib><creatorcontrib>MOCHIZUKI, NOBUHIRO</creatorcontrib><creatorcontrib>YANAGIDA, JITSURO</creatorcontrib><creatorcontrib>ARITA, KENICHI</creatorcontrib><creatorcontrib>DAIDO, KAZUHIRO</creatorcontrib><creatorcontrib>EJIMA, TSUYOSHI</creatorcontrib><creatorcontrib>MIKI, SATOSHI</creatorcontrib><creatorcontrib>SAWAE, YOSHIRO</creatorcontrib><creatorcontrib>YOSHIDA, MINORU</creatorcontrib><creatorcontrib>SHIRAISHI, TSUNEAKI</creatorcontrib><creatorcontrib>KAWAHARA, MASASHI</creatorcontrib><creatorcontrib>KAWAYAMA, TOMOTAKA</creatorcontrib><creatorcontrib>HONDA, YOSHIAKI</creatorcontrib><creatorcontrib>ISHIBASHI, TSUNEO</creatorcontrib><creatorcontrib>TAKAMOTO, MASAHIRO</creatorcontrib><creatorcontrib>KAJIKI, AKIRA</creatorcontrib><creatorcontrib>FUJISAWA, NOBUMITSU</creatorcontrib><creatorcontrib>SUGA, MORITAKA</creatorcontrib><creatorcontrib>DOI, TOSHINORI</creatorcontrib><creatorcontrib>TAKENAKA, SHINOBU</creatorcontrib><creatorcontrib>HARA, KOHEI</creatorcontrib><creatorcontrib>KOHNO, SHIGERU</creatorcontrib><creatorcontrib>KAKU, MITSUO</creatorcontrib><creatorcontrib>INOUE, YUICHI</creatorcontrib><creatorcontrib>YAMASHITA, YUKO</creatorcontrib><creatorcontrib>SAKATA, SHINGO</creatorcontrib><creatorcontrib>FUJII, TAKESHI</creatorcontrib><creatorcontrib>IRIFUNE, KENJI</creatorcontrib><creatorcontrib>MIYAZAKI, YOSHITSUGU</creatorcontrib><creatorcontrib>WATANABE, TAKASHI</creatorcontrib><creatorcontrib>MATSUMOTO, KEIZO</creatorcontrib><creatorcontrib>AKIYAMA, MORITOSHI</creatorcontrib><creatorcontrib>NAKAMA, KAORU</creatorcontrib><creatorcontrib>MATSUKURA, SHIGERU</creatorcontrib><creatorcontrib>MASHIMOTO, HIDEO</creatorcontrib><creatorcontrib>MUKAE, HIROSHI</creatorcontrib><creatorcontrib>DEGUCHI, KOICHI</creatorcontrib><creatorcontrib>NAKASHIMA, MITSUYOSHI</creatorcontrib><title>COMPARATIVE STUDY ON THE EFFICACY OF RITIPENEM ACOXIL AND CEFOTIAM HEXETIL IN CHRONIC LOWER RESPIRATORY TRACT INFECTIONS BY THE DOUBLE-BLIND METHOD</title><title>Japanese journal of antibiotics</title><addtitle>Jpn. J. Antibiotics</addtitle><description>To objectively evaluate the efficacy, safety and usefulness of the newly developed penem oral antibiotic, ritipenem acoxil (RIPM-AC), against chronic lower respiratory tract infections, we conducted a multi-center double-blind comparative study using cefotiam hexetil (CTM-HE) as a control drug. RIPM-AC was orally administered at 200 mg, and CTM-HE at 400 mg, t.i.d. for 14 days, in principle. The results were as follows: The total number of patients enrol led in this trial was 202, of which 151 cases (RIPM-AC group: 75, CTM-HE group: 76) were evaluable for clinical efficacy. 1. The clinical efficacy rates (excellent+good) were 85.3% (64/75) in the RIPM-AC group and 80.3% (61/76) in the CTM-HE group. There was no significant difference between the two groups, hence the clinical equivalency of RIPM-AC to CTM-HE was demonstrated. 2. In the patients enrolled in the evaluation of clinical efficacy, the eradication rates of the causative organisms were 50.0% (13/26) in the RIPM-AC group and 75.0% (18/24) in the CTM-HE group, with no significant difference between the two groups. 3. Side effects were noted in 10 cases (11.0%) of the RIPM-AC group and 10 cases (10.9%) of the CTM-HE group. Abnormal laboratory test findings were observed in 8 cases(9.5%) of the RIPM-AC group and in 14 cases (16.7%) of the CTM-HE group. There were no significant differences between the two groups in the incidence of side effects and abnormal laboratory test findings. In the safety evaluation, RIPM-AC was judged to be safe in 73 cases (80.2%) and CTM-HE in 71 cases (77.2%), with no significant difference. 4. The usefulness rates (markedly useful+useful) were 79.5% (62/78) in the RIPM-AC group and 76.9% (60/78) in the CTM-HE group. There was no significant difference between the two groups. Since RIPM-AC showed clinical efficacy similar to those of CTM-HE and posed no particular safety problems, it is expected to be a useful antibiotic for the treatment of chronic lower respiratory tract infCctions.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Bacterial Infections - drug therapy</subject><subject>Bacterial Infections - microbiology</subject><subject>Carbapenems - adverse effects</subject><subject>Carbapenems - therapeutic use</subject><subject>Cefotiam - adverse effects</subject><subject>Cefotiam - therapeutic use</subject><subject>Cephalosporins - adverse effects</subject><subject>Cephalosporins - therapeutic use</subject><subject>Chronic Disease</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>Humans</subject><subject>Japan</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Respiratory Tract Infections - drug therapy</subject><subject>Respiratory Tract Infections - microbiology</subject><issn>0368-2781</issn><issn>2186-5477</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdUctOwzAQtBCoVIVPQPIPpMSx48TH1HWIURpXqQv0FDlOCqnaUjXlwHfww5iHOHDZ1e6MZndnAYDIHyMUhvjW7E9d3b2eOtsjRuN6TNg4QOwMDAMUUy8kUXQOhj6msRdEMboE133f1T5GURw4hQEYxAyHCLEh-OBqNk_KRMsHARd6OV1BVUCdCSjSVPKEuzqFpdRyLgoxgwlXTzKHSTGFXKRKy2QGM_EktGvKAvKsVIXkMFePooSlWMyl01blCuoy4dpRUsG1VMUCTlbfY6ZqOcmFN8mlk5wJnanpFbhYm23fXv_mEVimQvPMy9WdWyn3NijwmWcjYhtDGbLYNyhqGrtuAmob0rY0YjVFpLbWHe07Im5C4zctjS2mlhBSh4jiEbj50T281bu2qQ7HbmeO79WvOQ6__8E3_ck8t3-4OTrnt231_w0VYRX-Cu4XfyT7Yo5Vu8efKEh65w</recordid><startdate>199603</startdate><enddate>199603</enddate><creator>KAWAKAMI, YOSHIKAZU</creator><creator>ABE, SHOSAKU</creator><creator>OHMICHI, MITSUHIDE</creator><creator>INOUE, HIROSHI</creator><creator>YOSHIDA, MASAMI</creator><creator>KOBAYASHI, HITOSHI</creator><creator>ITO, 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KEIZO</creator><creator>AKIYAMA, MORITOSHI</creator><creator>NAKAMA, KAORU</creator><creator>MATSUKURA, SHIGERU</creator><creator>MASHIMOTO, HIDEO</creator><creator>MUKAE, HIROSHI</creator><creator>DEGUCHI, KOICHI</creator><creator>NAKASHIMA, MITSUYOSHI</creator><general>Japan Antibiotics Research Association</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>199603</creationdate><title>COMPARATIVE STUDY ON THE EFFICACY OF RITIPENEM ACOXIL AND CEFOTIAM HEXETIL IN CHRONIC LOWER RESPIRATORY TRACT INFECTIONS BY THE DOUBLE-BLIND METHOD</title><author>KAWAKAMI, YOSHIKAZU ; ABE, SHOSAKU ; OHMICHI, MITSUHIDE ; INOUE, HIROSHI ; YOSHIDA, MASAMI ; KOBAYASHI, HITOSHI ; ITO, TAKASHI ; BANDO, TAKESHI ; TAKEUCHI, KENICHI ; HIRANO, HARUTO ; TANNO, YASUO ; SAKAMOTO, MASAHIRO ; NUKIWA, TOSHIHIRO ; YANASE, KENJI ; ITO, NOBUO ; FUKUDA, KIYOSHI ; KOBA, HIROYUKIYASHI ; WATANABE, HIDEHIRO ; INAMATSU, TAKASHI ; SANO, YASUYUKI ; KURAKI, TAKASHIGE ; SHISHIDO, HARUMI ; TANOUE, SHOKO ; KOYAMA, MASARU ; KUDO, KOICHIRO ; KOSHINO, TAKESHI ; OKUBO, TAKAO ; TANI, KENJI ; SHOJI, AKIRA ; CHIBA, JUN ; IKEHARA, KUNIHIKO ; SAKURAI, IWAO ; TAKAHASHI, HIROSHI ; ARAKAWA, MASAAKI ; WADA, KOICHI ; IWATA, FUMIHIDE ; TSUKADA, HIROKI ; SUZUKI, YASUTOSHI ; SATO, ATSUHIKO ; IWATA, MASATOSHI ; SHICHI, IZUMI ; YASUDA, KAZUMASA ; TAKAGI, KENZO ; WATANABE, YOSHIAKI ; TANIGUCHI, HIROYUKI ; USUI, ISAO ; BANDO, KENJI ; KISHIMOTO, TADAMITSU ; IKEDA, AKINORI ; OKUMOTO, TAKESHI ; MIKI, FUMIO ; OKAWA, KENTARO ; MIKASA, KEIICHI ; HIGASHINO, KAZUYA ; MAEBO, AKIO ; NOMURA, SHIGEO ; YAMAGUCHI, KAZUYUKI ; HIRABAYASHI, MASATAKA ; YOSHIDA, MASAO ; MATSUSHIMA, TOSHIHARU ; MATSUMOTO, YUKIO ; ISHIOKA, SHINICHI ; KUWAHARA, MASAO ; MOCHIZUKI, NOBUHIRO ; YANAGIDA, JITSURO ; ARITA, KENICHI ; DAIDO, KAZUHIRO ; EJIMA, TSUYOSHI ; MIKI, SATOSHI ; SAWAE, YOSHIRO ; YOSHIDA, MINORU ; SHIRAISHI, TSUNEAKI ; KAWAHARA, MASASHI ; KAWAYAMA, TOMOTAKA ; HONDA, YOSHIAKI ; ISHIBASHI, TSUNEO ; TAKAMOTO, MASAHIRO ; KAJIKI, AKIRA ; FUJISAWA, NOBUMITSU ; SUGA, MORITAKA ; DOI, TOSHINORI ; TAKENAKA, SHINOBU ; HARA, KOHEI ; KOHNO, SHIGERU ; KAKU, MITSUO ; INOUE, YUICHI ; YAMASHITA, YUKO ; SAKATA, SHINGO ; FUJII, TAKESHI ; IRIFUNE, KENJI ; MIYAZAKI, YOSHITSUGU ; WATANABE, TAKASHI ; MATSUMOTO, KEIZO ; AKIYAMA, MORITOSHI ; NAKAMA, KAORU ; MATSUKURA, SHIGERU ; MASHIMOTO, HIDEO ; MUKAE, HIROSHI ; DEGUCHI, KOICHI ; NAKASHIMA, MITSUYOSHI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-j1209-c74cda691c30a17ddcfd26cd4ee679b614bcc0310c743d5a0de68c36c444b5163</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>jpn</language><creationdate>1996</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Bacterial Infections - drug therapy</topic><topic>Bacterial Infections - microbiology</topic><topic>Carbapenems - adverse effects</topic><topic>Carbapenems - therapeutic use</topic><topic>Cefotiam - adverse effects</topic><topic>Cefotiam - therapeutic use</topic><topic>Cephalosporins - adverse effects</topic><topic>Cephalosporins - therapeutic use</topic><topic>Chronic Disease</topic><topic>Double-Blind Method</topic><topic>Female</topic><topic>Humans</topic><topic>Japan</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Respiratory Tract Infections - drug therapy</topic><topic>Respiratory Tract Infections - microbiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KAWAKAMI, YOSHIKAZU</creatorcontrib><creatorcontrib>ABE, SHOSAKU</creatorcontrib><creatorcontrib>OHMICHI, MITSUHIDE</creatorcontrib><creatorcontrib>INOUE, HIROSHI</creatorcontrib><creatorcontrib>YOSHIDA, MASAMI</creatorcontrib><creatorcontrib>KOBAYASHI, HITOSHI</creatorcontrib><creatorcontrib>ITO, TAKASHI</creatorcontrib><creatorcontrib>BANDO, TAKESHI</creatorcontrib><creatorcontrib>TAKEUCHI, 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KENJI</creatorcontrib><creatorcontrib>MIYAZAKI, YOSHITSUGU</creatorcontrib><creatorcontrib>WATANABE, TAKASHI</creatorcontrib><creatorcontrib>MATSUMOTO, KEIZO</creatorcontrib><creatorcontrib>AKIYAMA, MORITOSHI</creatorcontrib><creatorcontrib>NAKAMA, KAORU</creatorcontrib><creatorcontrib>MATSUKURA, SHIGERU</creatorcontrib><creatorcontrib>MASHIMOTO, HIDEO</creatorcontrib><creatorcontrib>MUKAE, HIROSHI</creatorcontrib><creatorcontrib>DEGUCHI, KOICHI</creatorcontrib><creatorcontrib>NAKASHIMA, MITSUYOSHI</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Japanese journal of antibiotics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KAWAKAMI, YOSHIKAZU</au><au>ABE, SHOSAKU</au><au>OHMICHI, MITSUHIDE</au><au>INOUE, HIROSHI</au><au>YOSHIDA, MASAMI</au><au>KOBAYASHI, HITOSHI</au><au>ITO, TAKASHI</au><au>BANDO, TAKESHI</au><au>TAKEUCHI, KENICHI</au><au>HIRANO, HARUTO</au><au>TANNO, YASUO</au><au>SAKAMOTO, MASAHIRO</au><au>NUKIWA, TOSHIHIRO</au><au>YANASE, KENJI</au><au>ITO, NOBUO</au><au>FUKUDA, KIYOSHI</au><au>KOBA, HIROYUKIYASHI</au><au>WATANABE, HIDEHIRO</au><au>INAMATSU, TAKASHI</au><au>SANO, YASUYUKI</au><au>KURAKI, TAKASHIGE</au><au>SHISHIDO, HARUMI</au><au>TANOUE, SHOKO</au><au>KOYAMA, MASARU</au><au>KUDO, KOICHIRO</au><au>KOSHINO, TAKESHI</au><au>OKUBO, TAKAO</au><au>TANI, KENJI</au><au>SHOJI, AKIRA</au><au>CHIBA, JUN</au><au>IKEHARA, KUNIHIKO</au><au>SAKURAI, IWAO</au><au>TAKAHASHI, HIROSHI</au><au>ARAKAWA, MASAAKI</au><au>WADA, KOICHI</au><au>IWATA, FUMIHIDE</au><au>TSUKADA, HIROKI</au><au>SUZUKI, YASUTOSHI</au><au>SATO, ATSUHIKO</au><au>IWATA, MASATOSHI</au><au>SHICHI, IZUMI</au><au>YASUDA, KAZUMASA</au><au>TAKAGI, KENZO</au><au>WATANABE, YOSHIAKI</au><au>TANIGUCHI, HIROYUKI</au><au>USUI, ISAO</au><au>BANDO, KENJI</au><au>KISHIMOTO, TADAMITSU</au><au>IKEDA, AKINORI</au><au>OKUMOTO, TAKESHI</au><au>MIKI, FUMIO</au><au>OKAWA, KENTARO</au><au>MIKASA, KEIICHI</au><au>HIGASHINO, KAZUYA</au><au>MAEBO, AKIO</au><au>NOMURA, SHIGEO</au><au>YAMAGUCHI, KAZUYUKI</au><au>HIRABAYASHI, MASATAKA</au><au>YOSHIDA, MASAO</au><au>MATSUSHIMA, TOSHIHARU</au><au>MATSUMOTO, YUKIO</au><au>ISHIOKA, SHINICHI</au><au>KUWAHARA, MASAO</au><au>MOCHIZUKI, NOBUHIRO</au><au>YANAGIDA, JITSURO</au><au>ARITA, KENICHI</au><au>DAIDO, KAZUHIRO</au><au>EJIMA, TSUYOSHI</au><au>MIKI, SATOSHI</au><au>SAWAE, YOSHIRO</au><au>YOSHIDA, MINORU</au><au>SHIRAISHI, TSUNEAKI</au><au>KAWAHARA, MASASHI</au><au>KAWAYAMA, TOMOTAKA</au><au>HONDA, YOSHIAKI</au><au>ISHIBASHI, TSUNEO</au><au>TAKAMOTO, MASAHIRO</au><au>KAJIKI, AKIRA</au><au>FUJISAWA, NOBUMITSU</au><au>SUGA, MORITAKA</au><au>DOI, TOSHINORI</au><au>TAKENAKA, SHINOBU</au><au>HARA, KOHEI</au><au>KOHNO, SHIGERU</au><au>KAKU, MITSUO</au><au>INOUE, YUICHI</au><au>YAMASHITA, YUKO</au><au>SAKATA, SHINGO</au><au>FUJII, TAKESHI</au><au>IRIFUNE, KENJI</au><au>MIYAZAKI, YOSHITSUGU</au><au>WATANABE, TAKASHI</au><au>MATSUMOTO, KEIZO</au><au>AKIYAMA, MORITOSHI</au><au>NAKAMA, KAORU</au><au>MATSUKURA, SHIGERU</au><au>MASHIMOTO, HIDEO</au><au>MUKAE, HIROSHI</au><au>DEGUCHI, KOICHI</au><au>NAKASHIMA, MITSUYOSHI</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>COMPARATIVE STUDY ON THE EFFICACY OF RITIPENEM ACOXIL AND CEFOTIAM HEXETIL IN CHRONIC LOWER RESPIRATORY TRACT INFECTIONS BY THE DOUBLE-BLIND METHOD</atitle><jtitle>Japanese journal of antibiotics</jtitle><addtitle>Jpn. J. Antibiotics</addtitle><date>1996-03</date><risdate>1996</risdate><volume>49</volume><issue>3</issue><spage>219</spage><epage>249</epage><pages>219-249</pages><issn>0368-2781</issn><eissn>2186-5477</eissn><abstract>To objectively evaluate the efficacy, safety and usefulness of the newly developed penem oral antibiotic, ritipenem acoxil (RIPM-AC), against chronic lower respiratory tract infections, we conducted a multi-center double-blind comparative study using cefotiam hexetil (CTM-HE) as a control drug. RIPM-AC was orally administered at 200 mg, and CTM-HE at 400 mg, t.i.d. for 14 days, in principle. The results were as follows: The total number of patients enrol led in this trial was 202, of which 151 cases (RIPM-AC group: 75, CTM-HE group: 76) were evaluable for clinical efficacy. 1. The clinical efficacy rates (excellent+good) were 85.3% (64/75) in the RIPM-AC group and 80.3% (61/76) in the CTM-HE group. There was no significant difference between the two groups, hence the clinical equivalency of RIPM-AC to CTM-HE was demonstrated. 2. In the patients enrolled in the evaluation of clinical efficacy, the eradication rates of the causative organisms were 50.0% (13/26) in the RIPM-AC group and 75.0% (18/24) in the CTM-HE group, with no significant difference between the two groups. 3. Side effects were noted in 10 cases (11.0%) of the RIPM-AC group and 10 cases (10.9%) of the CTM-HE group. Abnormal laboratory test findings were observed in 8 cases(9.5%) of the RIPM-AC group and in 14 cases (16.7%) of the CTM-HE group. There were no significant differences between the two groups in the incidence of side effects and abnormal laboratory test findings. In the safety evaluation, RIPM-AC was judged to be safe in 73 cases (80.2%) and CTM-HE in 71 cases (77.2%), with no significant difference. 4. The usefulness rates (markedly useful+useful) were 79.5% (62/78) in the RIPM-AC group and 76.9% (60/78) in the CTM-HE group. There was no significant difference between the two groups. Since RIPM-AC showed clinical efficacy similar to those of CTM-HE and posed no particular safety problems, it is expected to be a useful antibiotic for the treatment of chronic lower respiratory tract infCctions.</abstract><cop>Japan</cop><pub>Japan Antibiotics Research Association</pub><pmid>8935119</pmid><doi>10.11553/antibiotics1968b.49.219</doi><tpages>31</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0368-2781 |
| ispartof | The Japanese Journal of Antibiotics, 1996/03/25, Vol.49(3), pp.219-249 |
| issn | 0368-2781 2186-5477 |
| language | jpn |
| recordid | cdi_pubmed_primary_8935119 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adult Aged Aged, 80 and over Bacterial Infections - drug therapy Bacterial Infections - microbiology Carbapenems - adverse effects Carbapenems - therapeutic use Cefotiam - adverse effects Cefotiam - therapeutic use Cephalosporins - adverse effects Cephalosporins - therapeutic use Chronic Disease Double-Blind Method Female Humans Japan Male Middle Aged Respiratory Tract Infections - drug therapy Respiratory Tract Infections - microbiology |
| title | COMPARATIVE STUDY ON THE EFFICACY OF RITIPENEM ACOXIL AND CEFOTIAM HEXETIL IN CHRONIC LOWER RESPIRATORY TRACT INFECTIONS BY THE DOUBLE-BLIND METHOD |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-20T16%3A23%3A08IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed_jstag&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=COMPARATIVE%20STUDY%20ON%20THE%20EFFICACY%20OF%20RITIPENEM%20ACOXIL%20AND%20CEFOTIAM%20HEXETIL%20IN%20CHRONIC%20LOWER%20RESPIRATORY%20TRACT%20INFECTIONS%20BY%20THE%20DOUBLE-BLIND%20METHOD&rft.jtitle=Japanese%20journal%20of%20antibiotics&rft.au=KAWAKAMI,%20YOSHIKAZU&rft.date=1996-03&rft.volume=49&rft.issue=3&rft.spage=219&rft.epage=249&rft.pages=219-249&rft.issn=0368-2781&rft.eissn=2186-5477&rft_id=info:doi/10.11553/antibiotics1968b.49.219&rft_dat=%3Cpubmed_jstag%3E8935119%3C/pubmed_jstag%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/8935119&rfr_iscdi=true |