Silicosis and Lung Cancer among Workers in North Carolina Dusty Trades
In 1940—1983, 760 cases of silicosis were identified among male North Carolina (NC) workers in dusty trades. Vital status was ascertained through 1983 for 714 silicotics, and death certificates were obtained for 546 of the 550 decedents. The standardized mortality ratio (SMR) for lung cancer based o...
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| Veröffentlicht in: | Scandinavian Journal of Work, Environment ＆ Health Environment ＆ Health, 1995-01, Vol.21 (2), p.81-83 |
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| container_title | Scandinavian Journal of Work, Environment ＆ Health |
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| creator | Amandus, HE Shy, C Castellan, RM Blair, A Heineman, EF |
| description | In 1940—1983, 760 cases of silicosis were identified among male North Carolina (NC) workers in dusty trades. Vital status was ascertained through 1983 for 714 silicotics, and death certificates were obtained for 546 of the 550 decedents. The standardized mortality ratio (SMR) for lung cancer based on United States rates was 2.6 [95% confidence interval (95% CI) 1.8—3.6] for whites, 2.3 (95% CI 1.5—3.4) for whites unexposed to other known occupational carcinogens, and 2.4 (95% CI 1.5—3.6) for whites with no other exposure and diagnosed with silicosis while still employed in dusty trades. In addition, the age-and smoking-adjusted rate for silicotics was 3.9 times higher (95% CI 2.4—6.4) than that of nonsilicotic metal miners. This analysis effectively controlled for confounding by age, cigarette smoking, exposure to other occupational carcinogens, and detection bias. The results congrue with the hypothesis of an association between silicosis and lung cancer. |
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Vital status was ascertained through 1983 for 714 silicotics, and death certificates were obtained for 546 of the 550 decedents. The standardized mortality ratio (SMR) for lung cancer based on United States rates was 2.6 [95% confidence interval (95% CI) 1.8—3.6] for whites, 2.3 (95% CI 1.5—3.4) for whites unexposed to other known occupational carcinogens, and 2.4 (95% CI 1.5—3.6) for whites with no other exposure and diagnosed with silicosis while still employed in dusty trades. In addition, the age-and smoking-adjusted rate for silicotics was 3.9 times higher (95% CI 2.4—6.4) than that of nonsilicotic metal miners. This analysis effectively controlled for confounding by age, cigarette smoking, exposure to other occupational carcinogens, and detection bias. The results congrue with the hypothesis of an association between silicosis and lung cancer.</description><identifier>ISSN: 0355-3140</identifier><identifier>EISSN: 1795-990X</identifier><identifier>PMID: 8929698</identifier><language>eng</language><publisher>Finland: Scandinavian Journal of Work, Environment ＆ Health</publisher><subject>Carcinogens ; Cigarette smoking ; Confidence Intervals ; Dust - adverse effects ; Epidemiology of silica, silicosis and cancer ; Humans ; Incidence ; Lung neoplasms ; Lung Neoplasms - complications ; Lung Neoplasms - epidemiology ; Male ; Mining ; Mortality ; North Carolina - epidemiology ; Occupational Exposure - adverse effects ; Occupational health and safety ; Patient assessment ; Pneumoconiosis ; Risk Factors ; Silicon Dioxide - adverse effects ; Silicosis ; Silicosis - complications ; Silicosis - epidemiology ; Survival Rate ; Trade</subject><ispartof>Scandinavian Journal of Work, Environment ＆ Health, 1995-01, Vol.21 (2), p.81-83</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/40966482$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/40966482$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,57995,58228</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8929698$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Amandus, HE</creatorcontrib><creatorcontrib>Shy, C</creatorcontrib><creatorcontrib>Castellan, RM</creatorcontrib><creatorcontrib>Blair, A</creatorcontrib><creatorcontrib>Heineman, EF</creatorcontrib><title>Silicosis and Lung Cancer among Workers in North Carolina Dusty Trades</title><title>Scandinavian Journal of Work, Environment ＆ Health</title><addtitle>Scand J Work Environ Health</addtitle><description>In 1940—1983, 760 cases of silicosis were identified among male North Carolina (NC) workers in dusty trades. Vital status was ascertained through 1983 for 714 silicotics, and death certificates were obtained for 546 of the 550 decedents. The standardized mortality ratio (SMR) for lung cancer based on United States rates was 2.6 [95% confidence interval (95% CI) 1.8—3.6] for whites, 2.3 (95% CI 1.5—3.4) for whites unexposed to other known occupational carcinogens, and 2.4 (95% CI 1.5—3.6) for whites with no other exposure and diagnosed with silicosis while still employed in dusty trades. In addition, the age-and smoking-adjusted rate for silicotics was 3.9 times higher (95% CI 2.4—6.4) than that of nonsilicotic metal miners. This analysis effectively controlled for confounding by age, cigarette smoking, exposure to other occupational carcinogens, and detection bias. The results congrue with the hypothesis of an association between silicosis and lung cancer.</description><subject>Carcinogens</subject><subject>Cigarette smoking</subject><subject>Confidence Intervals</subject><subject>Dust - adverse effects</subject><subject>Epidemiology of silica, silicosis and cancer</subject><subject>Humans</subject><subject>Incidence</subject><subject>Lung neoplasms</subject><subject>Lung Neoplasms - complications</subject><subject>Lung Neoplasms - epidemiology</subject><subject>Male</subject><subject>Mining</subject><subject>Mortality</subject><subject>North Carolina - epidemiology</subject><subject>Occupational Exposure - adverse effects</subject><subject>Occupational health and safety</subject><subject>Patient assessment</subject><subject>Pneumoconiosis</subject><subject>Risk Factors</subject><subject>Silicon Dioxide - adverse effects</subject><subject>Silicosis</subject><subject>Silicosis - complications</subject><subject>Silicosis - epidemiology</subject><subject>Survival Rate</subject><subject>Trade</subject><issn>0355-3140</issn><issn>1795-990X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkN1KAzEQhYMotVYfQcgLLOR3k7mUarVQ9MKK3i3TJKup7W5Jdi_69m5pUYQZhsMHhzPnjIy5AV0AsI9zMmZS60JyxS7JVc5rxgRoYUZkZEFACXZMZq9xE12bY6bYeLrom086xcaFRHHbDuK9Td8hZRob-tym7mugqd3EBul9n7s9XSb0IV-Tixo3Odyc7oS8zR6W06di8fI4n94tChTAu8IZt2IlGmOtdFijCl6AcFJxtQKNQVvGTV1bBVyDrJ2xblgPzmtfAqKckNuj765fbYOvdiluMe2r0z9_fJ27Nv1ixaAslRUDnx05xhS7WK3bPjVD4OrQ1KGoigNoLirBOONcCMY0_y_sMFL-AFUgZGQ</recordid><startdate>19950101</startdate><enddate>19950101</enddate><creator>Amandus, HE</creator><creator>Shy, C</creator><creator>Castellan, RM</creator><creator>Blair, A</creator><creator>Heineman, EF</creator><general>Scandinavian Journal of Work, Environment ＆ Health</general><general>National Institute for Working Life</general><general>Finnish Institute of Occupational Health</general><general>National Institute of Occupational Health (Denmark)</general><general>National Institute of Occupational Health (Norway)</general><scope>188</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>19950101</creationdate><title>Silicosis and Lung Cancer among Workers in North Carolina Dusty Trades</title><author>Amandus, HE ; Shy, C ; Castellan, RM ; Blair, A ; Heineman, EF</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a291t-c7cb06a77883cafa4ed292c3414b95ae58017ff8491593fc78cc78d9cd5d69aa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Carcinogens</topic><topic>Cigarette smoking</topic><topic>Confidence Intervals</topic><topic>Dust - adverse effects</topic><topic>Epidemiology of silica, silicosis and cancer</topic><topic>Humans</topic><topic>Incidence</topic><topic>Lung neoplasms</topic><topic>Lung Neoplasms - complications</topic><topic>Lung Neoplasms - epidemiology</topic><topic>Male</topic><topic>Mining</topic><topic>Mortality</topic><topic>North Carolina - epidemiology</topic><topic>Occupational Exposure - adverse effects</topic><topic>Occupational health and safety</topic><topic>Patient assessment</topic><topic>Pneumoconiosis</topic><topic>Risk Factors</topic><topic>Silicon Dioxide - adverse effects</topic><topic>Silicosis</topic><topic>Silicosis - complications</topic><topic>Silicosis - epidemiology</topic><topic>Survival Rate</topic><topic>Trade</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Amandus, HE</creatorcontrib><creatorcontrib>Shy, C</creatorcontrib><creatorcontrib>Castellan, RM</creatorcontrib><creatorcontrib>Blair, A</creatorcontrib><creatorcontrib>Heineman, EF</creatorcontrib><collection>Airiti Library</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Scandinavian Journal of Work, Environment ＆ Health</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Amandus, HE</au><au>Shy, C</au><au>Castellan, RM</au><au>Blair, A</au><au>Heineman, EF</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Silicosis and Lung Cancer among Workers in North Carolina Dusty Trades</atitle><jtitle>Scandinavian Journal of Work, Environment ＆ Health</jtitle><addtitle>Scand J Work Environ Health</addtitle><date>1995-01-01</date><risdate>1995</risdate><volume>21</volume><issue>2</issue><spage>81</spage><epage>83</epage><pages>81-83</pages><issn>0355-3140</issn><eissn>1795-990X</eissn><abstract>In 1940—1983, 760 cases of silicosis were identified among male North Carolina (NC) workers in dusty trades. Vital status was ascertained through 1983 for 714 silicotics, and death certificates were obtained for 546 of the 550 decedents. The standardized mortality ratio (SMR) for lung cancer based on United States rates was 2.6 [95% confidence interval (95% CI) 1.8—3.6] for whites, 2.3 (95% CI 1.5—3.4) for whites unexposed to other known occupational carcinogens, and 2.4 (95% CI 1.5—3.6) for whites with no other exposure and diagnosed with silicosis while still employed in dusty trades. In addition, the age-and smoking-adjusted rate for silicotics was 3.9 times higher (95% CI 2.4—6.4) than that of nonsilicotic metal miners. This analysis effectively controlled for confounding by age, cigarette smoking, exposure to other occupational carcinogens, and detection bias. The results congrue with the hypothesis of an association between silicosis and lung cancer.</abstract><cop>Finland</cop><pub>Scandinavian Journal of Work, Environment ＆ Health</pub><pmid>8929698</pmid><tpages>3</tpages></addata></record> |
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| identifier | ISSN: 0355-3140 |
| ispartof | Scandinavian Journal of Work, Environment ＆ Health, 1995-01, Vol.21 (2), p.81-83 |
| issn | 0355-3140 1795-990X |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Jstor Complete Legacy |
| subjects | Carcinogens Cigarette smoking Confidence Intervals Dust - adverse effects Epidemiology of silica, silicosis and cancer Humans Incidence Lung neoplasms Lung Neoplasms - complications Lung Neoplasms - epidemiology Male Mining Mortality North Carolina - epidemiology Occupational Exposure - adverse effects Occupational health and safety Patient assessment Pneumoconiosis Risk Factors Silicon Dioxide - adverse effects Silicosis Silicosis - complications Silicosis - epidemiology Survival Rate Trade |
| title | Silicosis and Lung Cancer among Workers in North Carolina Dusty Trades |
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