Circadian blood pressure rhythm and atrial natriuretic peptide in prednisolone-induced blood pressure elevation
The effect of prednisolone, given as a 4-day oral treatment, on 24-h ambulatory blood pressure rhythm, vasoactive hormones and correlation between blood pressure and vasoactive hormones were studied in 11 healthy men. Blood pressure was monitored at intervals of 15 min during the day and of 30 min d...
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| Veröffentlicht in: | Scandinavian journal of clinical and laboratory investigation 1995, Vol.55 (8), p.655-662 |
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| creator | Ivarsen, P. Jensen, L. W. Pedersen, E. B. |
| description | The effect of prednisolone, given as a 4-day oral treatment, on 24-h ambulatory blood pressure rhythm, vasoactive hormones and correlation between blood pressure and vasoactive hormones were studied in 11 healthy men. Blood pressure was monitored at intervals of 15 min during the day and of 30 min during the night. Plasma concentrations of angiotensin II, aldosterone, atrial natriuretic peptide (ANP) and arginine vasopressin and serum concentration of insulin were measured in the morning during basal conditions.
The 24-h systolic, diastolic and mean blood pressures were significantly higher after prednisolone treatment. Waking blood pressure was not significantly changed, but sleeping systolic and mean blood pressures were significantly elevated after treatment. The nocturnal systolic blood pressure fall was less pronounced after treatment (before 22%, and after 16%, p |
| doi_str_mv | 10.3109/00365519509075395 |
| format | Article |
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The 24-h systolic, diastolic and mean blood pressures were significantly higher after prednisolone treatment. Waking blood pressure was not significantly changed, but sleeping systolic and mean blood pressures were significantly elevated after treatment. The nocturnal systolic blood pressure fall was less pronounced after treatment (before 22%, and after 16%, p<0.01), whereas the nocturnal, mean and diastolic dips were preserved. ANP was significantly increased by prednisolone treatment, from 10.1 to 14.6 pmol 1−1, p<0.005. The changes in concentration of ANP were significantly correlated to the changes in 24-h diastolic blood pressure (r = -0.63, p<0.05), 24-h mean blood pressure (r = -0.68, p<0.05), waking diastolic blood pressure (r = -0.83, p<0.01) and waking mean blood pressure (r = -0.67, p<0.01).
We found that short-term prednisolone treatment elevated the overall 24-h blood pressure, reduced systolic blood pressure fall during sleep, and increased plasma concentration of ANP, and that the increase in ANP was inversely correlated to the increase in blood pressure. We suggest that the increase in ANP is a secondary and compensatory phenomenon which at least to some extent counteracts the hypertensive and sodium retaining effect of prednisolone.]]></description><identifier>ISSN: 0036-5513</identifier><identifier>EISSN: 1502-7686</identifier><identifier>DOI: 10.3109/00365519509075395</identifier><identifier>PMID: 8903835</identifier><identifier>CODEN: SJCLAY</identifier><language>eng</language><publisher>Oslo: Informa UK Ltd</publisher><subject>24-h ambulatory blood pressure ; Adult ; aldosterone ; Aldosterone - blood ; Aldosterone - metabolism ; ambulatory blood pressure monitoring ; angiotensin II ; Angiotensin II - blood ; Angiotensin II - metabolism ; arginine vasopressin ; Atrial Natriuretic Factor - blood ; Atrial Natriuretic Factor - metabolism ; Biological and medical sciences ; Blood Glucose - drug effects ; Blood Pressure - drug effects ; Body Weight - drug effects ; circadian rhythm ; Circadian Rhythm - physiology ; Drug toxicity and drugs side effects treatment ; glucagon ; Heart Rate - drug effects ; Humans ; insulin ; Insulin - blood ; Male ; Medical sciences ; Middle Aged ; Pharmacology. Drug treatments ; Potassium - blood ; Potassium - urine ; Prednisolone - pharmacology ; Sodium - blood ; Sodium - urine ; Toxicity: cardiovascular system ; Vasopressins - blood ; Vasopressins - metabolism</subject><ispartof>Scandinavian journal of clinical and laboratory investigation, 1995, Vol.55 (8), p.655-662</ispartof><rights>1995 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1995</rights><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c430t-fc43f5f29cb19450ae38d2df2cc773cec31d48838a38bc59f360524a065077073</citedby><cites>FETCH-LOGICAL-c430t-fc43f5f29cb19450ae38d2df2cc773cec31d48838a38bc59f360524a065077073</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.3109/00365519509075395$$EPDF$$P50$$Ginformaworld$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.3109/00365519509075395$$EHTML$$P50$$Ginformaworld$$H</linktohtml><link.rule.ids>314,780,784,4024,27923,27924,27925,59647,59753,60436,60542,61221,61256,61402,61437</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2945901$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8903835$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ivarsen, P.</creatorcontrib><creatorcontrib>Jensen, L. W.</creatorcontrib><creatorcontrib>Pedersen, E. B.</creatorcontrib><title>Circadian blood pressure rhythm and atrial natriuretic peptide in prednisolone-induced blood pressure elevation</title><title>Scandinavian journal of clinical and laboratory investigation</title><addtitle>Scand J Clin Lab Invest</addtitle><description><![CDATA[The effect of prednisolone, given as a 4-day oral treatment, on 24-h ambulatory blood pressure rhythm, vasoactive hormones and correlation between blood pressure and vasoactive hormones were studied in 11 healthy men. Blood pressure was monitored at intervals of 15 min during the day and of 30 min during the night. Plasma concentrations of angiotensin II, aldosterone, atrial natriuretic peptide (ANP) and arginine vasopressin and serum concentration of insulin were measured in the morning during basal conditions.
The 24-h systolic, diastolic and mean blood pressures were significantly higher after prednisolone treatment. Waking blood pressure was not significantly changed, but sleeping systolic and mean blood pressures were significantly elevated after treatment. The nocturnal systolic blood pressure fall was less pronounced after treatment (before 22%, and after 16%, p<0.01), whereas the nocturnal, mean and diastolic dips were preserved. ANP was significantly increased by prednisolone treatment, from 10.1 to 14.6 pmol 1−1, p<0.005. The changes in concentration of ANP were significantly correlated to the changes in 24-h diastolic blood pressure (r = -0.63, p<0.05), 24-h mean blood pressure (r = -0.68, p<0.05), waking diastolic blood pressure (r = -0.83, p<0.01) and waking mean blood pressure (r = -0.67, p<0.01).
We found that short-term prednisolone treatment elevated the overall 24-h blood pressure, reduced systolic blood pressure fall during sleep, and increased plasma concentration of ANP, and that the increase in ANP was inversely correlated to the increase in blood pressure. We suggest that the increase in ANP is a secondary and compensatory phenomenon which at least to some extent counteracts the hypertensive and sodium retaining effect of prednisolone.]]></description><subject>24-h ambulatory blood pressure</subject><subject>Adult</subject><subject>aldosterone</subject><subject>Aldosterone - blood</subject><subject>Aldosterone - metabolism</subject><subject>ambulatory blood pressure monitoring</subject><subject>angiotensin II</subject><subject>Angiotensin II - blood</subject><subject>Angiotensin II - metabolism</subject><subject>arginine vasopressin</subject><subject>Atrial Natriuretic Factor - blood</subject><subject>Atrial Natriuretic Factor - metabolism</subject><subject>Biological and medical sciences</subject><subject>Blood Glucose - drug effects</subject><subject>Blood Pressure - drug effects</subject><subject>Body Weight - drug effects</subject><subject>circadian rhythm</subject><subject>Circadian Rhythm - physiology</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>glucagon</subject><subject>Heart Rate - drug effects</subject><subject>Humans</subject><subject>insulin</subject><subject>Insulin - blood</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pharmacology. Drug treatments</subject><subject>Potassium - blood</subject><subject>Potassium - urine</subject><subject>Prednisolone - pharmacology</subject><subject>Sodium - blood</subject><subject>Sodium - urine</subject><subject>Toxicity: cardiovascular system</subject><subject>Vasopressins - blood</subject><subject>Vasopressins - metabolism</subject><issn>0036-5513</issn><issn>1502-7686</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE-LFDEUxIMo67j6ATwIfRBvrUmn0-mgFxn8Bwte9Ny8SV6YLOmkTdLKfHvTzLigwp6KUL8q8oqQ54y-5oyqN5TyQQimBFVUCq7EA7JjgnatHMbhIdltflsB_pg8yfmW1jcf-ytyNSrKRy52JO5d0mAchObgYzTNkjDnNWGTjqdynBsIpoGSHPgmbFqt4nSz4FKcwcaFLWGCy9HHgK0LZtVo_i1Djz-huBiekkcWfMZnF70m3z9--Lb_3N58_fRl__6m1T2npbVVrLCd0gemekEB-Wg6YzutpeQaNWemH0c-Ah8PWijLByq6HuggqJRU8mvy6ty7pPhjxVym2WWN3kPAuOZJDkwOndhAdgZ1ijkntNOS3AzpNDE6bSNP_41cMy8u5ethRnOXuKxa_ZcXH7IGbxME7fId1tWLFGUVe3fGXLAxzfArJm-mAicf058Mv-8Xb_-KHxF8OWpION3GNYU67z03_AY1fast</recordid><startdate>1995</startdate><enddate>1995</enddate><creator>Ivarsen, P.</creator><creator>Jensen, L. W.</creator><creator>Pedersen, E. B.</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><general>Scandinavian University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1995</creationdate><title>Circadian blood pressure rhythm and atrial natriuretic peptide in prednisolone-induced blood pressure elevation</title><author>Ivarsen, P. ; Jensen, L. W. ; Pedersen, E. B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c430t-fc43f5f29cb19450ae38d2df2cc773cec31d48838a38bc59f360524a065077073</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>24-h ambulatory blood pressure</topic><topic>Adult</topic><topic>aldosterone</topic><topic>Aldosterone - blood</topic><topic>Aldosterone - metabolism</topic><topic>ambulatory blood pressure monitoring</topic><topic>angiotensin II</topic><topic>Angiotensin II - blood</topic><topic>Angiotensin II - metabolism</topic><topic>arginine vasopressin</topic><topic>Atrial Natriuretic Factor - blood</topic><topic>Atrial Natriuretic Factor - metabolism</topic><topic>Biological and medical sciences</topic><topic>Blood Glucose - drug effects</topic><topic>Blood Pressure - drug effects</topic><topic>Body Weight - drug effects</topic><topic>circadian rhythm</topic><topic>Circadian Rhythm - physiology</topic><topic>Drug toxicity and drugs side effects treatment</topic><topic>glucagon</topic><topic>Heart Rate - drug effects</topic><topic>Humans</topic><topic>insulin</topic><topic>Insulin - blood</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pharmacology. Drug treatments</topic><topic>Potassium - blood</topic><topic>Potassium - urine</topic><topic>Prednisolone - pharmacology</topic><topic>Sodium - blood</topic><topic>Sodium - urine</topic><topic>Toxicity: cardiovascular system</topic><topic>Vasopressins - blood</topic><topic>Vasopressins - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ivarsen, P.</creatorcontrib><creatorcontrib>Jensen, L. W.</creatorcontrib><creatorcontrib>Pedersen, E. B.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Scandinavian journal of clinical and laboratory investigation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ivarsen, P.</au><au>Jensen, L. W.</au><au>Pedersen, E. B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Circadian blood pressure rhythm and atrial natriuretic peptide in prednisolone-induced blood pressure elevation</atitle><jtitle>Scandinavian journal of clinical and laboratory investigation</jtitle><addtitle>Scand J Clin Lab Invest</addtitle><date>1995</date><risdate>1995</risdate><volume>55</volume><issue>8</issue><spage>655</spage><epage>662</epage><pages>655-662</pages><issn>0036-5513</issn><eissn>1502-7686</eissn><coden>SJCLAY</coden><abstract><![CDATA[The effect of prednisolone, given as a 4-day oral treatment, on 24-h ambulatory blood pressure rhythm, vasoactive hormones and correlation between blood pressure and vasoactive hormones were studied in 11 healthy men. Blood pressure was monitored at intervals of 15 min during the day and of 30 min during the night. Plasma concentrations of angiotensin II, aldosterone, atrial natriuretic peptide (ANP) and arginine vasopressin and serum concentration of insulin were measured in the morning during basal conditions.
The 24-h systolic, diastolic and mean blood pressures were significantly higher after prednisolone treatment. Waking blood pressure was not significantly changed, but sleeping systolic and mean blood pressures were significantly elevated after treatment. The nocturnal systolic blood pressure fall was less pronounced after treatment (before 22%, and after 16%, p<0.01), whereas the nocturnal, mean and diastolic dips were preserved. ANP was significantly increased by prednisolone treatment, from 10.1 to 14.6 pmol 1−1, p<0.005. The changes in concentration of ANP were significantly correlated to the changes in 24-h diastolic blood pressure (r = -0.63, p<0.05), 24-h mean blood pressure (r = -0.68, p<0.05), waking diastolic blood pressure (r = -0.83, p<0.01) and waking mean blood pressure (r = -0.67, p<0.01).
We found that short-term prednisolone treatment elevated the overall 24-h blood pressure, reduced systolic blood pressure fall during sleep, and increased plasma concentration of ANP, and that the increase in ANP was inversely correlated to the increase in blood pressure. We suggest that the increase in ANP is a secondary and compensatory phenomenon which at least to some extent counteracts the hypertensive and sodium retaining effect of prednisolone.]]></abstract><cop>Oslo</cop><pub>Informa UK Ltd</pub><pmid>8903835</pmid><doi>10.3109/00365519509075395</doi><tpages>8</tpages></addata></record> |
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| ispartof | Scandinavian journal of clinical and laboratory investigation, 1995, Vol.55 (8), p.655-662 |
| issn | 0036-5513 1502-7686 |
| language | eng |
| recordid | cdi_pubmed_primary_8903835 |
| source | MEDLINE; Taylor & Francis:Master (3349 titles); Taylor & Francis Medical Library - CRKN |
| subjects | 24-h ambulatory blood pressure Adult aldosterone Aldosterone - blood Aldosterone - metabolism ambulatory blood pressure monitoring angiotensin II Angiotensin II - blood Angiotensin II - metabolism arginine vasopressin Atrial Natriuretic Factor - blood Atrial Natriuretic Factor - metabolism Biological and medical sciences Blood Glucose - drug effects Blood Pressure - drug effects Body Weight - drug effects circadian rhythm Circadian Rhythm - physiology Drug toxicity and drugs side effects treatment glucagon Heart Rate - drug effects Humans insulin Insulin - blood Male Medical sciences Middle Aged Pharmacology. Drug treatments Potassium - blood Potassium - urine Prednisolone - pharmacology Sodium - blood Sodium - urine Toxicity: cardiovascular system Vasopressins - blood Vasopressins - metabolism |
| title | Circadian blood pressure rhythm and atrial natriuretic peptide in prednisolone-induced blood pressure elevation |
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