Microdialysis assessment of microfibrous collagen containing a P-glycoprotein-mediated transport inhibitor, cyclosporine A, for local delivery of etoposide

This study was designed to assess a local drug delivery system of an anticancer agent, etoposide (VP-16), using microfibrous collagen as a drug carrier. For this objective, the microdialysis method was utilized to investigate the local pharmacokinetics of VP-16. Microfibrous collagen sheets (CS) con...

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Veröffentlicht in:	Pharmaceutical research 1996-10, Vol.13 (10), p.1565-1569
Hauptverfasser:	SATO, H, KITAZAWA, H, ADACHI, I, HORIKOSHI, I
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Antineoplastic Agents, Phytogenic - administration & dosage Antineoplastic Agents, Phytogenic - blood Antineoplastic Agents, Phytogenic - pharmacokinetics ATP Binding Cassette Transporter, Subfamily B, Member 1 - antagonists & inhibitors Biliary Tract - metabolism Biological and medical sciences Biological Transport - drug effects Blood Proteins - metabolism Collagen - administration & dosage Cyclosporine - administration & dosage Cyclosporine - pharmacology Drug Carriers Drug Interactions Etoposide - administration & dosage Etoposide - blood Etoposide - pharmacokinetics Extracellular Space - metabolism General aspects Liver - metabolism Male Medical sciences Microdialysis Pharmacology. Drug treatments Protein Binding Rats Rats, Wistar
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