The association between participant characteristics and serum concentrations of beta-carotene, retinol, retinyl palmitate, and alpha-tocopherol among participants in the Carotene and Retinol Efficacy Trial (CARET) for prevention of lung cancer
As part of the multicenter Carotene and Retinol Efficacy Trial (CARET) lung cancer prevention study, we investigated the associations of baseline demographic, health history, and nutritional intake information and the prerandomization serum concentrations of beta-carotene, retinol, retinyl palmitate...
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| Veröffentlicht in: | Cancer epidemiology, biomarkers & prevention biomarkers & prevention, 1996-10, Vol.5 (10), p.815 |
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| creator | Goodman, G E Thornquist, M Kestin, M Metch, B Anderson, G Omenn, G S |
| description | As part of the multicenter Carotene and Retinol Efficacy Trial (CARET) lung cancer prevention study, we investigated the associations
of baseline demographic, health history, and nutritional intake information and the prerandomization serum concentrations
of beta-carotene, retinol, retinyl palmitate, and alpha-tocopherol in a random subset of 1182 smokers and asbestos-exposed
workers. Dietary intake was estimated via a self-administered food frequency questionnaire using the recently updated United
States Department of Agriculture/National Cancer Institute database. In multiple regression analyses, supplemental vitamin
use was the strongest predictor of each of the four analytes. There was a statistically significant inverse relationship between
smoking and beta-carotene concentrations. Lower serum beta-carotene was associated with current smoking, higher daily cigarettes
smoked, and more pack-years. Serum beta-carotene concentrations were higher with increasing years since stopping cigarette
use, which suggests a biological mechanism for the lower serum concentration of beta-carotene in smokers. We found weak inverse
associations between alcohol intake and the serum concentrations of both beta-carotene and retinol. As in previous reports,
dietary intakes as measured by a food frequency questionnaire can only moderately predict serum concentrations of beta-carotene,
retinol, retinyl palmitate, and alpha-tocopherol. |
| format | Article |
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of baseline demographic, health history, and nutritional intake information and the prerandomization serum concentrations
of beta-carotene, retinol, retinyl palmitate, and alpha-tocopherol in a random subset of 1182 smokers and asbestos-exposed
workers. Dietary intake was estimated via a self-administered food frequency questionnaire using the recently updated United
States Department of Agriculture/National Cancer Institute database. In multiple regression analyses, supplemental vitamin
use was the strongest predictor of each of the four analytes. There was a statistically significant inverse relationship between
smoking and beta-carotene concentrations. Lower serum beta-carotene was associated with current smoking, higher daily cigarettes
smoked, and more pack-years. Serum beta-carotene concentrations were higher with increasing years since stopping cigarette
use, which suggests a biological mechanism for the lower serum concentration of beta-carotene in smokers. We found weak inverse
associations between alcohol intake and the serum concentrations of both beta-carotene and retinol. As in previous reports,
dietary intakes as measured by a food frequency questionnaire can only moderately predict serum concentrations of beta-carotene,
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of baseline demographic, health history, and nutritional intake information and the prerandomization serum concentrations
of beta-carotene, retinol, retinyl palmitate, and alpha-tocopherol in a random subset of 1182 smokers and asbestos-exposed
workers. Dietary intake was estimated via a self-administered food frequency questionnaire using the recently updated United
States Department of Agriculture/National Cancer Institute database. In multiple regression analyses, supplemental vitamin
use was the strongest predictor of each of the four analytes. There was a statistically significant inverse relationship between
smoking and beta-carotene concentrations. Lower serum beta-carotene was associated with current smoking, higher daily cigarettes
smoked, and more pack-years. Serum beta-carotene concentrations were higher with increasing years since stopping cigarette
use, which suggests a biological mechanism for the lower serum concentration of beta-carotene in smokers. We found weak inverse
associations between alcohol intake and the serum concentrations of both beta-carotene and retinol. As in previous reports,
dietary intakes as measured by a food frequency questionnaire can only moderately predict serum concentrations of beta-carotene,
retinol, retinyl palmitate, and alpha-tocopherol.</description><subject>Alcohol Drinking - metabolism</subject><subject>Anticarcinogenic Agents - blood</subject><subject>Anticarcinogenic Agents - metabolism</subject><subject>Asbestos</subject><subject>beta Carotene - blood</subject><subject>Diet</subject><subject>Female</subject><subject>Food, Fortified</subject><subject>Humans</subject><subject>Lung Neoplasms - blood</subject><subject>Lung Neoplasms - epidemiology</subject><subject>Lung Neoplasms - prevention & control</subject><subject>Male</subject><subject>Micronutrients - metabolism</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Nutritional Status</subject><subject>Occupational Exposure</subject><subject>Regression Analysis</subject><subject>Smoking - metabolism</subject><subject>Vitamin A - analogs & derivatives</subject><subject>Vitamin A - blood</subject><subject>Vitamin E - blood</subject><subject>Vitamins - blood</subject><subject>Vitamins - metabolism</subject><issn>1055-9965</issn><issn>1538-7755</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkV1r2zAUhs3oSD-2nzA4d92gBsWy_HFZQroNCoOQXZvj46Naw5aMpKzkd-8PTGly0Ssd9PI-eiR9yG7WSjZ5XSt1lWahVN62lbrObkP4I4SoW6VW2app2qpp5U32bz8yYAiODEbjLPQcX5ktLOijIbOgjUAjeqTI3oS0FwDtAIH9YQZylthG_9YN4PSpjzmhd5EtP4DnaKybLsNxStxpNhFjyk4YnJYR8-jILSN7NwHOzr68Pz2AsRCT5eYCfevtzlzYam0I6Qh7b3CCr5vH3Xb_DbTzsHj-m9xOl0pe0yFhCZOu_5R91DgF_nxZ77LfT9v95kf-_Ov7z83jcz4Wsol5KwZBbVUMrErd96WULSopB6pIF6XUtSyGplmLXvSky15LWXKxrmoqyqofCiXvsi9n7nLoZx66xZsZ_bG7PH7K78_5aF7GV-O5O_t5Doyexk51a9E16UP_AyEmllg</recordid><startdate>19961001</startdate><enddate>19961001</enddate><creator>Goodman, G E</creator><creator>Thornquist, M</creator><creator>Kestin, M</creator><creator>Metch, B</creator><creator>Anderson, G</creator><creator>Omenn, G S</creator><general>American Association for Cancer Research</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>19961001</creationdate><title>The association between participant characteristics and serum concentrations of beta-carotene, retinol, retinyl palmitate, and alpha-tocopherol among participants in the Carotene and Retinol Efficacy Trial (CARET) for prevention of lung cancer</title><author>Goodman, G E ; 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of baseline demographic, health history, and nutritional intake information and the prerandomization serum concentrations
of beta-carotene, retinol, retinyl palmitate, and alpha-tocopherol in a random subset of 1182 smokers and asbestos-exposed
workers. Dietary intake was estimated via a self-administered food frequency questionnaire using the recently updated United
States Department of Agriculture/National Cancer Institute database. In multiple regression analyses, supplemental vitamin
use was the strongest predictor of each of the four analytes. There was a statistically significant inverse relationship between
smoking and beta-carotene concentrations. Lower serum beta-carotene was associated with current smoking, higher daily cigarettes
smoked, and more pack-years. Serum beta-carotene concentrations were higher with increasing years since stopping cigarette
use, which suggests a biological mechanism for the lower serum concentration of beta-carotene in smokers. We found weak inverse
associations between alcohol intake and the serum concentrations of both beta-carotene and retinol. As in previous reports,
dietary intakes as measured by a food frequency questionnaire can only moderately predict serum concentrations of beta-carotene,
retinol, retinyl palmitate, and alpha-tocopherol.</abstract><cop>United States</cop><pub>American Association for Cancer Research</pub><pmid>8896893</pmid></addata></record> |
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| ispartof | Cancer epidemiology, biomarkers & prevention, 1996-10, Vol.5 (10), p.815 |
| issn | 1055-9965 1538-7755 |
| language | eng |
| recordid | cdi_pubmed_primary_8896893 |
| source | MEDLINE; American Association for Cancer Research; EZB-FREE-00999 freely available EZB journals |
| subjects | Alcohol Drinking - metabolism Anticarcinogenic Agents - blood Anticarcinogenic Agents - metabolism Asbestos beta Carotene - blood Diet Female Food, Fortified Humans Lung Neoplasms - blood Lung Neoplasms - epidemiology Lung Neoplasms - prevention & control Male Micronutrients - metabolism Middle Aged Multivariate Analysis Nutritional Status Occupational Exposure Regression Analysis Smoking - metabolism Vitamin A - analogs & derivatives Vitamin A - blood Vitamin E - blood Vitamins - blood Vitamins - metabolism |
| title | The association between participant characteristics and serum concentrations of beta-carotene, retinol, retinyl palmitate, and alpha-tocopherol among participants in the Carotene and Retinol Efficacy Trial (CARET) for prevention of lung cancer |
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