Predictive Immunotoxicological Test Systems: Suitability of the Popliteal Lymph Node Assay in Mice and Rats

Abstract This article reviews results obtained with popliteal lymph node assays (PLNAs) in rodents and discusses their ability to detect and analyze immunotoxic effects of drugs and other low molecular weight (LMW) chemicals. In its basic form, the PLNA measures activation of the draining lymph node...

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Veröffentlicht in:	Critical reviews in toxicology 1995, Vol.25 (5), p.369-396
Hauptverfasser:	Bloksma, Nanne, Kubicka-muranyi, Malgorzata, Schuppe, Hans-Christian, Gleichmann, Ernst, Gleichmann, Helga
Format:	Artikel
Sprache:	eng
Schlagworte:	adverse immune reactions allergy Animals Autoimmunity Biological and medical sciences drug metabolites Drug-Related Side Effects and Adverse Reactions Hypersensitivity - immunology hypersensitivity reaction Immunological methods for diagnosis and exploration Immunopathology immunotoxicity Immunotoxins - toxicity local lymph node assays Lymph Nodes - drug effects Lymph Nodes - immunology Medical sciences Mice Mice, Inbred Strains Models, Immunological Molecular Weight Other methods Rats Research Design
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