Serial versus sparse sampling in toxicokinetic studies

Sparse sampling in rodent toxicokinetics usually involves the collection of a single blood sample on a given study day from each animal in a treatment group. The samples are allocated to different time points, often allowing some replicates, and statistical inferences are then made about the concent...

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Veröffentlicht in:	Pharmaceutical research 1996-07, Vol.13 (7), p.1105-1108
Hauptverfasser:	TSE, F. L. S, NEDELMAN, J. R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cholinesterase Inhibitors - administration & dosage Cholinesterase Inhibitors - blood Cholinesterase Inhibitors - pharmacokinetics Male Medical sciences Miscellaneous Pharmacokinetics Rats Rats, Sprague-Dawley Toxicity Tests - methods Toxicology Tritium
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