Five cases of drug-induced pneumonitis due to Sho-saiko-to or interferon-alpha or both
We encountered five cases of drug-induced pneumonitis due to Sho-saiko-to or interferon-alpha or both. In all 5 cases the underlying disease was chronic hepatitis or liver cirrhosis caused by hepatitis C virus. Interferon-alpha alone was administered in one case, Sho-saiko-to alone was administered...
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| Veröffentlicht in: | Nihon Kyōbu Shikkan Gakkai zasshi 1995-12, Vol.33 (12), p.1361 |
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| container_issue | 12 |
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| container_title | Nihon Kyōbu Shikkan Gakkai zasshi |
| container_volume | 33 |
| creator | Nakagawa, A Yamaguchi, T Takao, T Amano, H |
| description | We encountered five cases of drug-induced pneumonitis due to Sho-saiko-to or interferon-alpha or both. In all 5 cases the underlying disease was chronic hepatitis or liver cirrhosis caused by hepatitis C virus. Interferon-alpha alone was administered in one case, Sho-saiko-to alone was administered in two cases, and both were administered in two cases. Bronchoalveolar lavage was done in 4 cases. In three cases, lymphocytosis and abnormally low CD4/8 ratios were found on examination of bronchoalveolar lavage fluid. In the only case in which interferon-alpha alone was given the percentage of neutrophils in bronchoalveolar lavage fluid was abnormally high, and the adult respiratory distress syndrome developed. Lymphocyte stimulation tests were done in four cases, and in all four cases the only positive results were against Sho-saiko-to or against interferon-alpha. The frequency of drug-induced pneumonitis among patients with chronic hepatitis or liver cirrhosis was 0.7% in those given only Sho-saiko-to, 0.5% in those given only interferon-alpha, and 4.0% in those given both interferon-alpha and Sho-saiko-to. Therefore, pneumonitis due to Sho-saiko-to and to interferon-alpha is more likely to occur if these two drugs are given simultaneously. |
| doi_str_mv | 10.11389/jjrs1963.33.1361 |
| format | Article |
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In all 5 cases the underlying disease was chronic hepatitis or liver cirrhosis caused by hepatitis C virus. Interferon-alpha alone was administered in one case, Sho-saiko-to alone was administered in two cases, and both were administered in two cases. Bronchoalveolar lavage was done in 4 cases. In three cases, lymphocytosis and abnormally low CD4/8 ratios were found on examination of bronchoalveolar lavage fluid. In the only case in which interferon-alpha alone was given the percentage of neutrophils in bronchoalveolar lavage fluid was abnormally high, and the adult respiratory distress syndrome developed. Lymphocyte stimulation tests were done in four cases, and in all four cases the only positive results were against Sho-saiko-to or against interferon-alpha. The frequency of drug-induced pneumonitis among patients with chronic hepatitis or liver cirrhosis was 0.7% in those given only Sho-saiko-to, 0.5% in those given only interferon-alpha, and 4.0% in those given both interferon-alpha and Sho-saiko-to. Therefore, pneumonitis due to Sho-saiko-to and to interferon-alpha is more likely to occur if these two drugs are given simultaneously.</description><identifier>ISSN: 0301-1542</identifier><identifier>DOI: 10.11389/jjrs1963.33.1361</identifier><identifier>PMID: 8821988</identifier><language>jpn</language><publisher>Japan</publisher><subject>Aged ; Anti-Inflammatory Agents, Non-Steroidal - administration & dosage ; Chronic Disease ; Drug Therapy, Combination ; Drugs, Chinese Herbal - administration & dosage ; Drugs, Chinese Herbal - adverse effects ; Female ; Hepatitis C - therapy ; Humans ; Interferon-alpha - administration & dosage ; Interferon-alpha - adverse effects ; Liver Cirrhosis - therapy ; Male ; Middle Aged ; Pneumonia - chemically induced</subject><ispartof>Nihon Kyōbu Shikkan Gakkai zasshi, 1995-12, Vol.33 (12), p.1361</ispartof><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27915,27916</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8821988$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nakagawa, A</creatorcontrib><creatorcontrib>Yamaguchi, T</creatorcontrib><creatorcontrib>Takao, T</creatorcontrib><creatorcontrib>Amano, H</creatorcontrib><title>Five cases of drug-induced pneumonitis due to Sho-saiko-to or interferon-alpha or both</title><title>Nihon Kyōbu Shikkan Gakkai zasshi</title><addtitle>Nihon Kyobu Shikkan Gakkai Zasshi</addtitle><description>We encountered five cases of drug-induced pneumonitis due to Sho-saiko-to or interferon-alpha or both. In all 5 cases the underlying disease was chronic hepatitis or liver cirrhosis caused by hepatitis C virus. Interferon-alpha alone was administered in one case, Sho-saiko-to alone was administered in two cases, and both were administered in two cases. Bronchoalveolar lavage was done in 4 cases. In three cases, lymphocytosis and abnormally low CD4/8 ratios were found on examination of bronchoalveolar lavage fluid. In the only case in which interferon-alpha alone was given the percentage of neutrophils in bronchoalveolar lavage fluid was abnormally high, and the adult respiratory distress syndrome developed. Lymphocyte stimulation tests were done in four cases, and in all four cases the only positive results were against Sho-saiko-to or against interferon-alpha. The frequency of drug-induced pneumonitis among patients with chronic hepatitis or liver cirrhosis was 0.7% in those given only Sho-saiko-to, 0.5% in those given only interferon-alpha, and 4.0% in those given both interferon-alpha and Sho-saiko-to. Therefore, pneumonitis due to Sho-saiko-to and to interferon-alpha is more likely to occur if these two drugs are given simultaneously.</description><subject>Aged</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - administration & dosage</subject><subject>Chronic Disease</subject><subject>Drug Therapy, Combination</subject><subject>Drugs, Chinese Herbal - administration & dosage</subject><subject>Drugs, Chinese Herbal - adverse effects</subject><subject>Female</subject><subject>Hepatitis C - therapy</subject><subject>Humans</subject><subject>Interferon-alpha - administration & dosage</subject><subject>Interferon-alpha - adverse effects</subject><subject>Liver Cirrhosis - therapy</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Pneumonia - chemically induced</subject><issn>0301-1542</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNotj81KAzEURrNQaql9ABdCXiA1N0nHZCnFqlBw4c-23CR3bGo7GZIZwbdXsauPcxYHPsauQC4AtHU3-32p4Bq90HoBuoEzNpVagoClURdsXmvyUkpnpFZqwibWKnDWTtn7On0RD1ip8tzyWMYPkbo4Boq872g85i4NqfI4Eh8yf9llUTF9ZvELufDUDVRaKrkTeOh3-Od8HnaX7LzFQ6X5aWfsbX3_unoUm-eHp9XdRuzh1lgR0KgWXVAe0ITGRYsBdHDopSe7dAiNDbZV1pFxBq0iDxpDdI6APKGesev_bj_6I8VtX9IRy_f29E__AG5gU24</recordid><startdate>199512</startdate><enddate>199512</enddate><creator>Nakagawa, A</creator><creator>Yamaguchi, T</creator><creator>Takao, T</creator><creator>Amano, H</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>199512</creationdate><title>Five cases of drug-induced pneumonitis due to Sho-saiko-to or interferon-alpha or both</title><author>Nakagawa, A ; Yamaguchi, T ; Takao, T ; Amano, H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-j1748-ca42fa9c2b1a4c69d8ac13c9ab0be859a168c8f289e494a82eb13acd99e1ebea3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>jpn</language><creationdate>1995</creationdate><topic>Aged</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - administration & dosage</topic><topic>Chronic Disease</topic><topic>Drug Therapy, Combination</topic><topic>Drugs, Chinese Herbal - administration & dosage</topic><topic>Drugs, Chinese Herbal - adverse effects</topic><topic>Female</topic><topic>Hepatitis C - therapy</topic><topic>Humans</topic><topic>Interferon-alpha - administration & dosage</topic><topic>Interferon-alpha - adverse effects</topic><topic>Liver Cirrhosis - therapy</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Pneumonia - chemically induced</topic><toplevel>online_resources</toplevel><creatorcontrib>Nakagawa, A</creatorcontrib><creatorcontrib>Yamaguchi, T</creatorcontrib><creatorcontrib>Takao, T</creatorcontrib><creatorcontrib>Amano, H</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Nihon Kyōbu Shikkan Gakkai zasshi</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nakagawa, A</au><au>Yamaguchi, T</au><au>Takao, T</au><au>Amano, H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Five cases of drug-induced pneumonitis due to Sho-saiko-to or interferon-alpha or both</atitle><jtitle>Nihon Kyōbu Shikkan Gakkai zasshi</jtitle><addtitle>Nihon Kyobu Shikkan Gakkai Zasshi</addtitle><date>1995-12</date><risdate>1995</risdate><volume>33</volume><issue>12</issue><spage>1361</spage><pages>1361-</pages><issn>0301-1542</issn><abstract>We encountered five cases of drug-induced pneumonitis due to Sho-saiko-to or interferon-alpha or both. In all 5 cases the underlying disease was chronic hepatitis or liver cirrhosis caused by hepatitis C virus. Interferon-alpha alone was administered in one case, Sho-saiko-to alone was administered in two cases, and both were administered in two cases. Bronchoalveolar lavage was done in 4 cases. In three cases, lymphocytosis and abnormally low CD4/8 ratios were found on examination of bronchoalveolar lavage fluid. In the only case in which interferon-alpha alone was given the percentage of neutrophils in bronchoalveolar lavage fluid was abnormally high, and the adult respiratory distress syndrome developed. Lymphocyte stimulation tests were done in four cases, and in all four cases the only positive results were against Sho-saiko-to or against interferon-alpha. The frequency of drug-induced pneumonitis among patients with chronic hepatitis or liver cirrhosis was 0.7% in those given only Sho-saiko-to, 0.5% in those given only interferon-alpha, and 4.0% in those given both interferon-alpha and Sho-saiko-to. Therefore, pneumonitis due to Sho-saiko-to and to interferon-alpha is more likely to occur if these two drugs are given simultaneously.</abstract><cop>Japan</cop><pmid>8821988</pmid><doi>10.11389/jjrs1963.33.1361</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0301-1542 |
| ispartof | Nihon Kyōbu Shikkan Gakkai zasshi, 1995-12, Vol.33 (12), p.1361 |
| issn | 0301-1542 |
| language | jpn |
| recordid | cdi_pubmed_primary_8821988 |
| source | J-STAGE Free; MEDLINE |
| subjects | Aged Anti-Inflammatory Agents, Non-Steroidal - administration & dosage Chronic Disease Drug Therapy, Combination Drugs, Chinese Herbal - administration & dosage Drugs, Chinese Herbal - adverse effects Female Hepatitis C - therapy Humans Interferon-alpha - administration & dosage Interferon-alpha - adverse effects Liver Cirrhosis - therapy Male Middle Aged Pneumonia - chemically induced |
| title | Five cases of drug-induced pneumonitis due to Sho-saiko-to or interferon-alpha or both |
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