A microbiological method for the rapid determination of antibiotic concentrations during therapy (author's transl)
The assay described is an agar diffusion test using Bacillus stearothermophilus as test organism. Incubation is at 62 degrees C; results can be obtained rapidly within 2 to 3 hours. The test was developed for the determination of gentamicin concentrations in serum and other body fluids. Because of i...
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| Veröffentlicht in: | Infection 1977, Vol.5 (2), p.117 |
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| container_title | Infection |
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| creator | Wahlig, H |
| description | The assay described is an agar diffusion test using Bacillus stearothermophilus as test organism. Incubation is at 62 degrees C; results can be obtained rapidly within 2 to 3 hours. The test was developed for the determination of gentamicin concentrations in serum and other body fluids. Because of its high sensitivity the test strain is also suitable for the determination of other antibiotics. The test is designed primarily for the determination of concentrations in individual samples and thus for monitoring during therapy. The ease with which the test can be carried out is thus an important feature of it. On comparison with a standard method (agar diffusion test) using both serum samples from patients and samples with known gentamicin concentrations a highly significant correlation (r = 0.95) was seen between the two methods. |
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Incubation is at 62 degrees C; results can be obtained rapidly within 2 to 3 hours. The test was developed for the determination of gentamicin concentrations in serum and other body fluids. Because of its high sensitivity the test strain is also suitable for the determination of other antibiotics. The test is designed primarily for the determination of concentrations in individual samples and thus for monitoring during therapy. The ease with which the test can be carried out is thus an important feature of it. On comparison with a standard method (agar diffusion test) using both serum samples from patients and samples with known gentamicin concentrations a highly significant correlation (r = 0.95) was seen between the two methods.</description><identifier>ISSN: 0300-8126</identifier><identifier>PMID: 881260</identifier><language>ger</language><publisher>Germany</publisher><subject>Agar ; Anti-Bacterial Agents - blood ; Anti-Bacterial Agents - therapeutic use ; Biological Assay - methods ; Geobacillus stearothermophilus ; Humans ; Time Factors</subject><ispartof>Infection, 1977, Vol.5 (2), p.117</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,4010</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/881260$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wahlig, H</creatorcontrib><title>A microbiological method for the rapid determination of antibiotic concentrations during therapy (author's transl)</title><title>Infection</title><addtitle>Infection</addtitle><description>The assay described is an agar diffusion test using Bacillus stearothermophilus as test organism. 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On comparison with a standard method (agar diffusion test) using both serum samples from patients and samples with known gentamicin concentrations a highly significant correlation (r = 0.95) was seen between the two methods.</description><subject>Agar</subject><subject>Anti-Bacterial Agents - blood</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Biological Assay - methods</subject><subject>Geobacillus stearothermophilus</subject><subject>Humans</subject><subject>Time Factors</subject><issn>0300-8126</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1977</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFjrkOwjAQRF1wH39AsR1QIBnCWSIE4gPokWM7yaLYG62dgr8nHD3VSDPzRtMSfZlIudgvV9ueGITwkFJuDutdV3T2b1P2BR_BoWZKkUrKUasSnI0FGciIIRYWWFVowNho2aFXEckDZaB8xAaKqEGT19ZH_mQBTM3o8zfboE-YqbrZ42mApuFDOR-JdqbKYMc_HYrJ5Xw7XRdVnTpr7hWjU_y8fy8mf-IXb3lIfw</recordid><startdate>1977</startdate><enddate>1977</enddate><creator>Wahlig, H</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>1977</creationdate><title>A microbiological method for the rapid determination of antibiotic concentrations during therapy (author's transl)</title><author>Wahlig, H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-pubmed_primary_8812603</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>ger</language><creationdate>1977</creationdate><topic>Agar</topic><topic>Anti-Bacterial Agents - blood</topic><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>Biological Assay - methods</topic><topic>Geobacillus stearothermophilus</topic><topic>Humans</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wahlig, H</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Infection</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wahlig, H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A microbiological method for the rapid determination of antibiotic concentrations during therapy (author's transl)</atitle><jtitle>Infection</jtitle><addtitle>Infection</addtitle><date>1977</date><risdate>1977</risdate><volume>5</volume><issue>2</issue><spage>117</spage><pages>117-</pages><issn>0300-8126</issn><abstract>The assay described is an agar diffusion test using Bacillus stearothermophilus as test organism. Incubation is at 62 degrees C; results can be obtained rapidly within 2 to 3 hours. The test was developed for the determination of gentamicin concentrations in serum and other body fluids. Because of its high sensitivity the test strain is also suitable for the determination of other antibiotics. The test is designed primarily for the determination of concentrations in individual samples and thus for monitoring during therapy. The ease with which the test can be carried out is thus an important feature of it. On comparison with a standard method (agar diffusion test) using both serum samples from patients and samples with known gentamicin concentrations a highly significant correlation (r = 0.95) was seen between the two methods.</abstract><cop>Germany</cop><pmid>881260</pmid></addata></record> |
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| ispartof | Infection, 1977, Vol.5 (2), p.117 |
| issn | 0300-8126 |
| language | ger |
| recordid | cdi_pubmed_primary_881260 |
| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Agar Anti-Bacterial Agents - blood Anti-Bacterial Agents - therapeutic use Biological Assay - methods Geobacillus stearothermophilus Humans Time Factors |
| title | A microbiological method for the rapid determination of antibiotic concentrations during therapy (author's transl) |
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