Structure and Functions of the 20S and 26S Proteasomes

The proteasome is an essential component of the ATP-dependent proteolytic pathway in eukaryotic cells and is responsible for the degradation of most cellular proteins. The 20S (700-kDa) proteasome contains multiple peptidase activities that function through a new type of proteolytic mechanism involv...

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Veröffentlicht in:	Annual review of biochemistry 1996-01, Vol.65 (1), p.801-847
Hauptverfasser:	Coux, Olivier, Tanaka, Keiji, Goldberg, Alfred L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals ATPase Autoantigens Cysteine Endopeptidases - chemistry Cysteine Endopeptidases - metabolism Humans multicatalytic proteinase Multienzyme Complexes - chemistry Multienzyme Complexes - metabolism Muscle Proteins protease Proteasome Endopeptidase Complex protein degradation, ubiquitin Structure-Activity Relationship
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